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Protein Overview: GID8

General Information:
Name(s) found: GID8 / YMR135C [SGD]
Description(s) found:
Found 23 descriptions.
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  • Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains LisH and CTLH domains, like Vid30p; dosage-dependent regulator of START [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 455 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: negative regulation of gluconeogenesis [IMPLink to PubMed article]
    traversing start control point of mitotic cell cycle [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTISTLSNET TKSGSCSGQG KNGGKDFTYG KKCFTKEEWK EQVAKYSAMG ELYANKTIHY  60
   61 PLKIQPNSSG GSQDEGFATI QTTPIEPTLP RLLLNYFVSM AYEDSSIRMA KELGFIRNNK 120
  121 DIAVFNDLYK IKERFHIKHL IKLGRINEAM EEINSIFGLE VLEETFNATG SYTGRTDRQQ 180
  181 QQQQQQFDID GDLHFKLLLL NLIEMIRSHH QQENITKDSN DFILNLIQYS QNKLAIKASS 240
  241 SVKKMQELEL AMTLLLFPLS DSADSGSIKL PKSLQNLYSI SLRSKIADLV NEKLLKFIHP 300
  301 RIQFEISNNN SKFPDLLNSD KKIITQNFTV YNNNLVNGSN GTKITHISSD QPINEKMSSN 360
  361 EVTAAANSVW LNQRDGNVGT GSAATTFHNL ENKNYWNQTS ELLSSSNGKE KGLEFNNYYS 420
  421 SEFPYEPRLT QIMKLWCWCE NQLHHNQIGV PRVEN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) FYV10 GID7 GID8 RMD5 VID24 VID28 VID30 YDL176W
    View Details Krogan NJ, et al. (2006) FYV10 GID7 GID8 RMD5 VID24 VID28 VID30 YDL176W
    View Details Ho Y, et al. (2002) ASF1 CCT2 CCT3 CTF19 FYV10 GID7 GID8 HTA2 HXT7 IPP1 MDH1 MOH1 PAA1 RAD53 RMD5 SHS1 SMC3 TFP1 UME1 UTP22 VID24 VID28 VID30

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PAN1 No Comments Toshima J, et al (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data GID8 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..350] MSA 13.025968 View MSA. No confident structure predictions are available.
    2 View Details [351..455] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle