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Protein Overview: RMD5

General Information:
Name(s) found: RMD5 / YDR255C [SGD]
Description(s) found:
Found 37 descriptions.
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  • Conserved protein that has an E3-like ubiquitin ligase activity necessary for polyubiquitination and degradation of the gluconeogenic enzyme fructose-1,6-bisphosphatase; also required for sporulation; has a degenerate RING finger domain [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 421 amino acids

    Gene Ontology:
    Cellular Component: cytosol [IDALink to PubMed article]
    Biological Process: negative regulation of gluconeogenesis [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSELLDSFET EFAKFYTDSN LEETNLQKCL DHTHEFKSQL KKLKAHLNKH IQESKPEVYN  60
   61 KLSDKEKQKF KRKRELIIEK LSKSQRQWDH SVKKQIKYVS QQSNRFNKST LNKLKEFDID 120
  121 SVYVNKLPKE TMENVNEAIG YHILRYSIDN MPLGNKNEAF QYLKDVYGIT NKESTEFIEM 180
  181 GQIVHDLKKG DTESCLKWCS NEMESLSSNH TALSSLKFDL YTLSAMQIVK HGNPVELYYQ 240
  241 ITQNAPLDCF RHREKELMQN VVPLLTKSLI GQPIEDIDSK VNKELKECTS LFIKEYCAAK 300
  301 HIFFDSPLFL IVLSGLISFQ FFIKYKTIRE LAHVDWTTKD ELPFDVKLPD FLTHFHPIFI 360
  361 CPVLKEETTT ENPPYSLACH HIISKKALDR LSKNGTITFK CPYCPVNTSM SSTKKVRFVM 420
  421 L

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) FYV10 GID7 GID8 RMD5 VID24 VID28 VID30 YDL176W
    View Details Krogan NJ, et al. (2006) FYV10 GID7 GID8 RMD5 VID24 VID28 VID30 YDL176W
    View Details Ho Y, et al. (2002) CCT2 CCT3 FYV10 GID7 GID8 HXT7 MOH1 RMD5 SHS1 TFP1 VID24 VID28 VID30

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..72] MSA 1.021992 View MSA. No confident structure predictions are available.
    2 View Details [73..280] MSA 4.034995 View MSA. No confident structure predictions are available.
    3 View Details [281..421] MSA 1.02697 View MSA. Confident ab initio structure predictions are available.
    4 View Details [316..421] PSI-BLAST 3.69897 Solution Structure of the RING domain of the Tripartite motif protein 32


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.61

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle