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View Structure Prediction Details

Protein: ARC1
Organism: Saccharomyces cerevisiae
Length: 376 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ARC1.

Description E-value Query
Range
Subject
Range
gi|1002712 - gi|1002712|gb|AAC49072.1| G4p1
6.0E-89 [1..376] [1..375]
ARC1_SCHPO - tRNA-aminoacylation cofactor arc1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC30C2...
SPAC30C2.04 - cofactor for methionyl-and glutamyl-tRNA synthetases
3.0E-67 [4..375] [83..449]
gi|34907808, gi|... - gi|34907808|ref|NP_915251.1| similar to methionyl-tRNA synthetase [Oryza sativa (japonica cultivar-g...
2.0E-66 [2..376] [38..409]
gi|25408718, gi|... - gi|4895232|gb|AAD32818.1|AC007660_19 putative methionyl-tRNA synthetase [Arabidopsis thaliana], pir|...
1.0E-57 [2..376] [82..440]
gi|4140279, gi|4... - gi|4140281|emb|CAA10536.1| aminoacyl-tRNA synthetase cofactor [Euplotes octocarinatus], gi|4140279|e...
3.0E-52 [6..360] [67..434]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
6.0E-52 [132..376] [76..310]
gi|1619592 - gi|1619592|emb|CAA69993.1| human EMAPII [synthetic construct]
gi|10120516, gi|... - gi|10120517|pdb|1EUJ|B Chain B, A Novel Anti-Tumor Cytokine Contains A Rna-Binding Motif Present In ...
3.0E-51 [202..376] [2..166]
AIMP1_MOUSE - Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 OS=Mus musculus GN=Aimp1 PE=1 ...
3.0E-51 [133..376] [77..310]

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Predicted Domain #1
Region A:
Residues: [1-139]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDLVTKFES LIISKYPVSF TKEQSAQAAQ WESVLKSGQI QPHLDQLNLV LRDNTFIVST  60
   61 LYPTSTDVHV FEVALPLIKD LVASSKDVKS TYTTYRHILR WIDYMQNLLE VSSTDKLEIN 120
  121 HDLDLPHEVI EKKKKAPAG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.221849
Match: 1jlvA_
Description: Class delta GST
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.24470496646396 bayes_pls_golite062009
catalytic activity 0.963623964325467 bayes_pls_golite062009
protein binding 0.608998866513518 bayes_pls_golite062009
transferase activity, transferring alkyl or aryl (other than methyl) groups 0.44372379417457 bayes_pls_golite062009
transferase activity 0.352222179598631 bayes_pls_golite062009
transporter activity 0.343837470835258 bayes_pls_golite062009
glutathione transferase activity 0.20688408808374 bayes_pls_golite062009
transcription regulator activity 0.184452716814807 bayes_pls_golite062009
nucleic acid binding 0.17259853770512 bayes_pls_golite062009
transmembrane transporter activity 0.141575430891772 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [140-198]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GAADAAAKAD EDVSKKAKKQ DHPRGKPDEE TLKKLREEAK AKKAAKKAAN AKQQQEQQN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
ligase activity, forming carbon-oxygen bonds 7.22739538544605 bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds 7.22739538544605 bayes_pls_golite062009
aminoacyl-tRNA ligase activity 7.21678612388154 bayes_pls_golite062009
ligase activity 5.98606099120849 bayes_pls_golite062009
isoleucine-tRNA ligase activity 3.76808520367507 bayes_pls_golite062009
catalytic activity 1.41356903593784 bayes_pls_golite062009
arginine-tRNA ligase activity 1.15514226827836 bayes_pls_golite062009
binding 1.12496911405027 bayes_pls_golite062009
protein binding 0.341429946042706 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [199-376]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KAPEKPKPSA IDFRVGFIQK AIKHPDADSL YVSTIDVGDE EGPRTVCSGL VKHFPLDAMQ  60
   61 ERYVVVVCNL KPVNMRGIKS TAMVLCGSND DKVEFVEPPK DSKAGDKVFF EGFGDEAPMK 120
  121 QLNPKKKIWE HLQPHFTTND GLEVIFKDEE EKDHPVRKLT NAKGESFKVA SIANAQVR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 422.09691
Match: 1eujA_
Description: EMAP II
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle