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View Structure Prediction Details

Protein: ARC1
Organism: Saccharomyces cerevisiae
Length: 376 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ARC1.

Description E-value Query
Range
Subject
Range
gi|1002712 - gi|1002712|gb|AAC49072.1| G4p1
6.0E-89 [1..376] [1..375]
ARC1_SCHPO - tRNA-aminoacylation cofactor arc1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC30C2...
SPAC30C2.04 - cofactor for methionyl-and glutamyl-tRNA synthetases
3.0E-67 [4..375] [83..449]
gi|34907808, gi|... - gi|34907808|ref|NP_915251.1| similar to methionyl-tRNA synthetase [Oryza sativa (japonica cultivar-g...
2.0E-66 [2..376] [38..409]
gi|25408718, gi|... - gi|4895232|gb|AAD32818.1|AC007660_19 putative methionyl-tRNA synthetase [Arabidopsis thaliana], pir|...
1.0E-57 [2..376] [82..440]
gi|4140279, gi|4... - gi|4140281|emb|CAA10536.1| aminoacyl-tRNA synthetase cofactor [Euplotes octocarinatus], gi|4140279|e...
3.0E-52 [6..360] [67..434]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
6.0E-52 [132..376] [76..310]
gi|1619592 - gi|1619592|emb|CAA69993.1| human EMAPII [synthetic construct]
gi|10120516, gi|... - gi|10120517|pdb|1EUJ|B Chain B, A Novel Anti-Tumor Cytokine Contains A Rna-Binding Motif Present In ...
3.0E-51 [202..376] [2..166]
AIMP1_MOUSE - Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 OS=Mus musculus GN=Aimp1 PE=1 ...
3.0E-51 [133..376] [77..310]

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Predicted Domain #1
Region A:
Residues: [1-139]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDLVTKFES LIISKYPVSF TKEQSAQAAQ WESVLKSGQI QPHLDQLNLV LRDNTFIVST  60
   61 LYPTSTDVHV FEVALPLIKD LVASSKDVKS TYTTYRHILR WIDYMQNLLE VSSTDKLEIN 120
  121 HDLDLPHEVI EKKKKAPAG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.221849
Match: 1jlvA_
Description: Class delta GST
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.24470496646396 bayes_pls_golite062009
catalytic activity 0.963623964325467 bayes_pls_golite062009
protein binding 0.608998866513518 bayes_pls_golite062009
transferase activity, transferring alkyl or aryl (other than methyl) groups 0.44372379417457 bayes_pls_golite062009
transferase activity 0.352222179598631 bayes_pls_golite062009
transporter activity 0.343837470835258 bayes_pls_golite062009
glutathione transferase activity 0.20688408808374 bayes_pls_golite062009
transcription regulator activity 0.184452716814807 bayes_pls_golite062009
nucleic acid binding 0.17259853770512 bayes_pls_golite062009
transmembrane transporter activity 0.141575430891772 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [140-198]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GAADAAAKAD EDVSKKAKKQ DHPRGKPDEE TLKKLREEAK AKKAAKKAAN AKQQQEQQN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.386 a.39.1 EF-hand
View Download 0.396 a.4.1 Homeodomain-like
View Download 0.389 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.415 a.5.2 UBA-like
View Download 0.547 a.163.1 Crustacean CHH/MIH/GIH neurohormone
View Download 0.385 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.372 g.15.1 Ovomucoid/PCI-1 like inhibitors
View Download 0.340 a.4.5 "Winged helix" DNA-binding domain
View Download 0.323 a.4.1 Homeodomain-like
View Download 0.305 a.4.5 "Winged helix" DNA-binding domain
View Download 0.286 a.4.5 "Winged helix" DNA-binding domain
View Download 0.285 a.16.1 S15/NS1 RNA-binding domain
View Download 0.285 a.153.1 Nuclear receptor coactivator interlocking domain
View Download 0.283 a.144.2 Ribosomal protein L20
View Download 0.267 a.77.1 DEATH domain
View Download 0.266 a.4.1 Homeodomain-like
View Download 0.249 a.164.1 C-terminal domain of DFF45/ICAD (DFF-C domain)
View Download 0.247 a.4.5 "Winged helix" DNA-binding domain
View Download 0.212 a.23.4 Mitochondrial import receptor subunit Tom20
View Download 0.203 a.4.13 Sigma3 and sigma4 domains of RNA polymerase sigma factors
View Download 0.203 a.2.7 tRNA-binding arm

Predicted functions:

Term Confidence Notes
ligase activity, forming carbon-oxygen bonds 7.22739538544605 bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds 7.22739538544605 bayes_pls_golite062009
aminoacyl-tRNA ligase activity 7.21678612388154 bayes_pls_golite062009
ligase activity 5.98606099120849 bayes_pls_golite062009
isoleucine-tRNA ligase activity 3.76808520367507 bayes_pls_golite062009
catalytic activity 1.41356903593784 bayes_pls_golite062009
arginine-tRNA ligase activity 1.15514226827836 bayes_pls_golite062009
binding 1.12496911405027 bayes_pls_golite062009
protein binding 0.341429946042706 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [199-376]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KAPEKPKPSA IDFRVGFIQK AIKHPDADSL YVSTIDVGDE EGPRTVCSGL VKHFPLDAMQ  60
   61 ERYVVVVCNL KPVNMRGIKS TAMVLCGSND DKVEFVEPPK DSKAGDKVFF EGFGDEAPMK 120
  121 QLNPKKKIWE HLQPHFTTND GLEVIFKDEE EKDHPVRKLT NAKGESFKVA SIANAQVR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 422.09691
Match: 1eujA_
Description: EMAP II
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle