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View Structure Prediction Details

Protein: SAH1
Organism: Saccharomyces cerevisiae
Length: 449 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SAH1.

Description E-value Query
Range		 Subject
Range
AHCY - adenosylhomocysteinase
gi|61362062, gi|... - gi|61362062|gb|AAX42153.1| S-adenosylhomocysteine hydrolase [synthetic construct], gi|124126827|gb|A...
gi|114681558 - gi|114681558|ref|XP_514594.2| PREDICTED: S-adenosylhomocysteine hydrolase [Pan troglodytes]
 0.0 [3..449] [2..432]
SAHH_MOUSE - Adenosylhomocysteinase OS=Mus musculus GN=Ahcy PE=1 SV=3
gi|38197378 - gi|38197378|gb|AAH61841.1| Ahcy protein [Rattus norvegicus]
gi|55716011 - gb|AAH86108.1| Unknown (protein for MGC:98492) [Xenopus laevis]
 0.0 [3..449] [2..432]
SAHH_RAT - (P10760) Adenosylhomocysteinase (EC 3.3.1.1) (S-adenosyl-L-homocysteine hydrolase) (AdoHcyase)
 0.0 [3..449] [1..431]
SAHHA_XENLA - Adenosylhomocysteinase A OS=Xenopus laevis GN=ahcy-a PE=2 SV=1
 0.0 [3..449] [2..433]
gi|190405605 - gi|190405605|gb|EDV08872.1| S-adenosyl-L-homocysteine hydrolase [Saccharomyces cerevisiae RM11-1a]
gi|207345981 - gi|207345981|gb|EDZ72617.1| YER043Cp-like protein [Saccharomyces cerevisiae AWRI1631]
SAHH_YEAST - Adenosylhomocysteinase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SAH1 PE=1 SV=1
gi|151944753 - gi|151944753|gb|EDN63012.1| S-adenosyl-L-homocysteine hydrolase [Saccharomyces cerevisiae YJM789]
SAH1 - S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after don...
 0.0 [1..449] [1..449]

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Predicted Domain #1
Region A:
Residues: [1-193] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAPAQNYKI ADISLAAFGR KEIELAEHEM PGLMAIRKAY GDVQPLKGAR IAGCLHMTIQ  60
   61 TAVLIETLVA LGAEVTWSSC NIYSTQDHAA AAIAASGVPV FAWKGETEEE YLWCIEQQLF 120
  121 AFKDNKKLNL ILDDGGDLTT LVHEKHPEML EDCFGLSEET TTGVHHLYRM VKEGKLKVPA 180
  181 INVNDSVTKS KFD

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [356-449] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HSSFVMSCSF SNQVLAQIAL FKSNDKSFRE KHIEFQKTGP FEVGVHVLPK ILDEAVAKFH  60
   61 LGNLGVRLTK LSKVQSEYLG IPEEGPFKAD HYRY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10163.0
Match: 1b3rA_
Description: S-adenosylhomocystein hydrolase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
adenosylhomocysteinase activity 4.75102111339352 bayes_pls_golite062009
trialkylsulfonium hydrolase activity 4.75102111339352 bayes_pls_golite062009
catalytic activity 1.79741889688267 bayes_pls_golite062009
oxidoreductase activity 0.9367410227151 bayes_pls_golite062009
binding 0.784517759335365 bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors 0.418775403210681 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.32207755075663 bayes_pls_golite062009
DNA binding 0.158019531459925 bayes_pls_golite062009
nucleic acid binding 0.0191997392158629 bayes_pls_golite062009
transcription regulator activity 0.012678711735872 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [194-355] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NLYGCRESLV DGIKRATDVM LAGKVAVVAG YGDVGKGCAA ALRGMGARVL VTEIDPINAL  60
   61 QAAMEGYQVV TMEDASHIGQ VFVTTTGCRD IINGEHFINM PEDAIVCNIG HFDIEIDVAW 120
  121 LKANAKECIN IKPQVDRYLL SSGRHVILLA NGRLVNLGCA TG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10163.0
Match: 1b3rA_
Description: S-adenosylhomocystein hydrolase
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle