Protein Overview: SPE3

General Information:
Name(s) found:	SPE3 / YPR069C [SGD]
Description(s) found: Found 31 descriptions. SHOW ALL	Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells [SGD]
Organism:	Saccharomyces cerevisiae
Length:	293 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] cytoplasm [IDA]
Biological Process:	pantothenate biosynthetic process [IMP] spermidine biosynthetic process [IMP]
Molecular Function:	spermidine synthase activity [IMP][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAQEITHPTI VDGWFREISD TMWPGQAMTL KVEKVLHHEK SKYQDVLIFK STTYGNVLVL  60
   61 DNVIQATERD EFAYQEMIAH LALNSHPNPK KVLVIGGGDG GVLREVVKHD SVEEAWLCDI 120
  121 DEAVIRLSKE YLPEMAASYS HPKVKTHIGD GFQFLRDYQN TFDVIITDSS DPEGPAETLF 180
  181 QKEYFQLLNS ALTEKGVITT QAESMWIHLP IIKDLKKACS EVFPVAEYSF VTIPTYPTGT 240
  241 IGFMVCSKDK TCNVKKPLRE ISDEKEAELY RYYNKKIHEA SFVLPTWAAK ELN

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		SPE3 SPE4
View Details	Krogan NJ, et al. (2006)		ALA1 ARO1 DUG1 GDH1 HIS4 HIS6 HRD1 MET6 OYE2 RAD14 SCP160 SPE3 SPE4 TIM11 URA6 YLF2 YRB2
View Details	Gavin AC, et al. (2002)		SPE3 SPE4
View Details	Ho Y, et al. (2002)		AAC3 ADK1 ARP4 ASA1 ATG17 ATG29 ATP3 ATP5 ATP7 CDC14 CDC33 CIC1 CIS1 CYS4 DPM1 FOL2 FUR1 GLC7 GRH1 HAP2 HAP5 HEF3 HMS1 IPP1 LOC1 MAM33 MCR1 MTQ1 NAP1 NMD5 NOP16 NSA2 POL5 PSE1 RHR2 SAH1 SAP190 SNF4 SPE3 SSK2 SSZ1 TIF1, TIF2 TIF6 TPS1 TSA2 VAS1 YRA1 YRA2 YTM1

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	SPE3	Huh WK, et al. (2003)

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

Term	Confidence	Notes
spermidine synthase activity	2.31131562815571	bayes_pls_golite062009
transferase activity	1.77671966857605	bayes_pls_golite062009
transcription regulator activity	1.61435611638306	bayes_pls_golite062009
DNA binding	1.53375495589674	bayes_pls_golite062009
nucleic acid binding	1.31440474302645	bayes_pls_golite062009
catalytic activity	1.25333584501255	bayes_pls_golite062009
binding	0.976078016260105	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	0.837368219068434	bayes_pls_golite062009
N-methyltransferase activity	0.69697643153076	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	0.644010137949015	bayes_pls_golite062009
methyltransferase activity	0.635463629299812	bayes_pls_golite062009
protein methyltransferase activity	0.57386401278889	bayes_pls_golite062009

No functions predicted.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

Protein Overview: SPE3

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..65]	PSI-BLAST	589.39794	Spermidine synthase
2	View Details	[66..293]	PSI-BLAST	589.39794	Spermidine synthase