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Protein Overview: FUR1

General Information:
Name(s) found: FUR1 / YHR128W [SGD]
Description(s) found:
Found 16 descriptions.
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  • Uracil phosphoribosyltransferase, synthesizes UMP from uracil; involved in the pyrimidine salvage pathway [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 216 amino acids

    Gene Ontology:
    Cellular Component: intracellular [ICLink to PubMed article]
    Biological Process: pyrimidine salvage [IDALink to PubMed article]
    Molecular Function: uracil phosphoribosyltransferase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSEPFKNVY LLPQTNQLLG LYTIIRNKNT TRPDFIFYSD RIIRLLVEEG LNHLPVQKQI  60
   61 VETDTNENFE GVSFMGKICG VSIVRAGESM EQGLRDCCRS VRIGKILIQR DEETALPKLF 120
  121 YEKLPEDISE RYVFLLDPML ATGGSAIMAT EVLIKRGVKP ERIYFLNLIC SKEGIEKYHA 180
  181 AFPEVRIVTG ALDRGLDENK YLVPGLGDFG DRYYCV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Gavin AC, et al. (2006) FUR1 RVB2 SAR1 SEC53 YDR341C YNK1
    View Details Ho Y, et al. (2002) ADK1 ATP3 ATP5 ATP7 CDC14 DPM1 FUR1 GLC7 HEF3 HMS1 MCR1 SNF4 SPE3 SSZ1 TPS1 TSA2 VAS1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..216] PSI-BLAST 61.30103 Uracil PRTase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • uracil phosphoribosyltransferase activity
    		•  3.97944228585882 bayes_pls_golite062009
  • transferase activity, transferring glycosyl groups
    		•  3.91023158228049 bayes_pls_golite062009
  • adenine phosphoribosyltransferase activity
    		•  3.07502596276449 bayes_pls_golite062009
  • transferase activity
    		•  2.73727660668741 bayes_pls_golite062009
  • hypoxanthine phosphoribosyltransferase activity
    		•  2.67945744445872 bayes_pls_golite062009
  • transferase activity, transferring pentosyl groups
    		•  2.53679639481311 bayes_pls_golite062009
  • catalytic activity
    		•  2.30431811394775 bayes_pls_golite062009
  • ribose phosphate diphosphokinase activity
    		•  0.947697983706416 bayes_pls_golite062009
  • diphosphotransferase activity
    		•  0.749909396904601 bayes_pls_golite062009
  • binding
    		•  0.730385736169604 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.552133387792911 bayes_pls_golite062009
  • DNA binding
    		•  0.439741935655503 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.396538943915776 bayes_pls_golite062009
  • amidophosphoribosyltransferase activity
    		•  0.360901350940423 bayes_pls_golite062009
  • purine binding
    		•  0.358545436706029 bayes_pls_golite062009
  • orotate phosphoribosyltransferase activity
    		•  0.148898393751978 bayes_pls_golite062009
  • nucleobase binding
    		•  0.0803493215714011 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle