Protein Overview: FUR1

General Information:
Name(s) found:	FUR1 / YHR128W [SGD]
Description(s) found: Found 16 descriptions. SHOW ALL	Uracil phosphoribosyltransferase, synthesizes UMP from uracil; involved in the pyrimidine salvage pathway [SGD]
Organism:	Saccharomyces cerevisiae
Length:	216 amino acids
Gene Ontology:
Cellular Component:	intracellular [IC]
Biological Process:	pyrimidine salvage [IDA]
Molecular Function:	uracil phosphoribosyltransferase activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSEPFKNVY LLPQTNQLLG LYTIIRNKNT TRPDFIFYSD RIIRLLVEEG LNHLPVQKQI  60
   61 VETDTNENFE GVSFMGKICG VSIVRAGESM EQGLRDCCRS VRIGKILIQR DEETALPKLF 120
  121 YEKLPEDISE RYVFLLDPML ATGGSAIMAT EVLIKRGVKP ERIYFLNLIC SKEGIEKYHA 180
  181 AFPEVRIVTG ALDRGLDENK YLVPGLGDFG DRYYCV

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Gavin AC, et al. (2006)		FUR1 RVB2 SAR1 SEC53 YDR341C YNK1
View Details	Ho Y, et al. (2002)		ADK1 ATP3 ATP5 ATP7 CDC14 DPM1 FUR1 GLC7 HEF3 HMS1 MCR1 SNF4 SPE3 SSZ1 TPS1 TSA2 VAS1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RPA135	his-HA tag on RPA135	Schneider, DA, et al. (2006)
View Run	RPA135	his-HA tag on RPA135	Schneider, DA, et al. (2006)
View Run	MLP2	#32 Asynchronous Prep-No Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	KAP104	FUR1	1	Unpublished Fields Lab Data
View Screen	SPT21	FUR1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..216]	PSI-BLAST	61.30103	Uracil PRTase

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
uracil phosphoribosyltransferase activity	3.97944228585882	bayes_pls_golite062009
transferase activity, transferring glycosyl groups	3.91023158228049	bayes_pls_golite062009
adenine phosphoribosyltransferase activity	3.07502596276449	bayes_pls_golite062009
transferase activity	2.73727660668741	bayes_pls_golite062009
hypoxanthine phosphoribosyltransferase activity	2.67945744445872	bayes_pls_golite062009
transferase activity, transferring pentosyl groups	2.53679639481311	bayes_pls_golite062009
catalytic activity	2.30431811394775	bayes_pls_golite062009
ribose phosphate diphosphokinase activity	0.947697983706416	bayes_pls_golite062009
diphosphotransferase activity	0.749909396904601	bayes_pls_golite062009
binding	0.730385736169604	bayes_pls_golite062009
nucleic acid binding	0.552133387792911	bayes_pls_golite062009
DNA binding	0.439741935655503	bayes_pls_golite062009
transcription regulator activity	0.396538943915776	bayes_pls_golite062009
amidophosphoribosyltransferase activity	0.360901350940423	bayes_pls_golite062009
purine binding	0.358545436706029	bayes_pls_golite062009
orotate phosphoribosyltransferase activity	0.148898393751978	bayes_pls_golite062009
nucleobase binding	0.0803493215714011	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.94

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2