Protein Overview: SRC1

General Information:
Name(s) found:	SRC1 / YML034W [SGD]
Description(s) found: Found 23 descriptions. SHOW ALL	Inner nuclear membrane protein that functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; possible role in chromatid segregation [SGD]
Organism:	Saccharomyces cerevisiae
Length:	834 amino acids
Gene Ontology:
Cellular Component:	cellular_component [ND]
Biological Process:	mitotic sister chromatid segregation [IGI]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSDLEYLED GFDPNSMKVA TLRRILVENN VDFPSNARKN ALVGLFDEKV KPQIPQLRKM  60
   61 YLNVRPSDEG IVKMDRPSSS PSIASPRRSR RARREKSASP MAKQFKKNRI LDDVSNDDDD 120
  121 DDDDDDDNDK KDDPLIVPSG TDTDEVDDEE DDVITSSSNK SDTNDFQQNS DTRKKRKDPD 180
  181 SDDWSESNSK ENKIDNKHLN LLSSDSEIEQ DYQKAKKRKT SDLNQEHGNG SAILGKLSVK 240
  241 TPIKNTNRKP VSMDNFNDSL TSSGTENDPF VPNIRHNPKE LGTANGTGHS TPLSKLKVSA 300
  301 SFADKLPQKE VPSTILVPEV EQQEPSQSER TPSLFSSEGS GSESEAPLLP EITTPGPHQP 360
  361 MGNTSNNVVE MIDTDSSNLV SDEDEVLVPT RIETPQLPTE KDVEKCEARV QELQEEVNEQ 420
  421 LEHENGSEFD VKQGSGKVGN RHKFKRALKF LSKSLLALFL FCIFIVIPLL FGLWYREQRL 480
  481 LIGYCGHEVP SHRVSGNSFE FIQKLDNLLQ DYRPKCIPCP PNGICYPYLK LKCKPDYKLA 540
  541 PSRLDFLEII PAQGKCVKDD KKQQLVSEVV EKSLEFLRAK NAQISCGDGK DDIESGMTED 600
  601 ALYQIFNEAR APWIRDDEFE DLWIQVIKDL TEEPEILWRQ LSPTDNNIGG NSNNIIKTND 660
  661 VPRQKRHLPE KFISKTRNFR STSKKYIGMK CRFEREIYQT YKKFQRPIWL MFLLIVISKV 720
  721 IEIKLKNYYR KKARIEELVT QTMEKLKFQK IKSMSDPKEN AYLSIVQLRD IFLSDIVDLK 780
  781 YKNQLWSEVV KYLEHNNSNI KSNLTEIRGE IMKCWEWIGP MELNEPKDSA ENKI

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	(MIPS) Mewes HW, et al. (2004)		ESP1 PDS1 SRC1
View Details	Krogan NJ, et al. (2006)		ATG33 BUB1 CUL3 GUT1 ISM1 MEC3 MLC1 MYO2 MYO4 RGA1 RSB1 SAT4 SHE2 SHE3 SHE4 SRC1 SSH4 STT4 TOF2 TVP18 YDR186C YOL098C

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)
View Run	MLP2	#24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#03 Alpha Factor Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	SRC1	SLD5	2	Unpublished Fields Lab Data
View Screen	SRC1	DSK2	2	Unpublished Fields Lab Data

Microscopy / Localization Data

New Feature: Upload Your Own Microscopy Data

	PROTEIN(S)	PUBLICATION
View Data	SRC1	Huh WK, et al. (2003)
View Data	SRC1 and NIC96	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..149]	MSA	1.355996	View MSA. No confident structure predictions are available.
2	View Details	[150..436]	ORFEUS	7.17	Microbial transglutaminase
3	View Details	[437..678]	deduced	N/A	No confident structure predictions are available.
4	View Details	[679..834]	MSA	5.011996	View MSA. Confident ab initio structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2