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Protein Overview: DSK2

General Information:
Name(s) found: DSK2 / YMR276W [SGD]
Description(s) found:
Found 18 descriptions.
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  • Nuclear-enriched ubiquitin-like polyubiquitin-binding protein, required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle, involved in proteolysis, interacts with the proteasome [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 373 amino acids

    Gene Ontology:
    Cellular Component: nucleus [TASLink to PubMed article]
    Biological Process: spindle pole body duplication in nuclear envelope [TASLink to PubMed article]
    ER-associated protein catabolic process [IMPLink to PubMed article]
    Molecular Function: protein binding, bridging [IMPLink to PubMed article][IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLNIHIKSG QDKWEVNVAP ESTVLQFKEA INKANGIPVA NQRLIYSGKI LKDDQTVESY  60
   61 HIQDGHSVHL VKSQPKPQTA SAAGANNATA TGAAAGTGAT PNMSSGQSAG FNPLADLTSA 120
  121 RYAGYLNMPS ADMFGPDGGA LNNDSNNQDE LLRMMENPIF QSQMNEMLSN PQMLDFMIQS 180
  181 NPQLQAMGPQ ARQMLQSPMF RQMLTNPDMI RQSMQFARMM DPNAGMGSAG GAASAFPAPG 240
  241 GDAPEEGSNT NTTSSSNTGN NAGTNAGTNA GANTAANPFA SLLNPALNPF ANAGNAASTG 300
  301 MPAFDPALLA SMFQPPVQAS QAEDTRPPEE RYEHQLRQLN DMGFFDFDRN VAALRRSGGS 360
  361 VQGALDSLLN GDV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) DSK2 LYP1 PDH1
    View Details Ho Y, et al. (2002) DSK2 HMF1 NPL4 RAD23 SHP1 TSL1 UBI4 UFD2 YDR049W

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SRC1 DSK2 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data DSK2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..107] PSI-BLAST 110.703922 Rub1
    2 View Details [108..259] MSA 2.096982 View MSA. No confident structure predictions are available.
    3 View Details [260..329] deduced N/A No confident structure predictions are available.
    4 View Details [330..373] PSI-BLAST 11.30103 DNA repair protein Hhr23a

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  3.35791544110308 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  1.83465130904364 bayes_pls_golite062009
  • protein binding
    		•  1.76858817153382 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.42747465816672 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.32707653701567 bayes_pls_golite062009
  • DNA binding
    		•  1.22622447288034 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  1.16468510691469 bayes_pls_golite062009
  • tubulin binding
    		•  1.11505425062041 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  0.919595189902044 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.907853439770547 bayes_pls_golite062009
  • microtubule binding
    		•  0.84012258724586 bayes_pls_golite062009
  • hydrolase activity
    		•  0.247201449341942 bayes_pls_golite062009
    2
    Term Confidence Notes
  • binding
    		•  2.9974054448593 bayes_pls_golite062009
  • DNA binding
    		•  2.7109101781315 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.65801759476965 bayes_pls_golite062009
  • damaged DNA binding
    		•  2.33590042963509 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.57741426576729 bayes_pls_golite062009
  • ubiquitin binding
    		•  1.38611607035372 bayes_pls_golite062009
  • small conjugating protein binding
    		•  1.25128759629714 bayes_pls_golite062009
  • protein binding
    		•  0.989474580552798 bayes_pls_golite062009
  • hydrolase activity
    		•  0.365329242181237 bayes_pls_golite062009
  • catalytic activity
    		•  0.2736776367506 bayes_pls_golite062009
  • peptidase activity
    		•  0.0113950255895392 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle