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View Structure Prediction Details

Protein: DSK2
Organism: Saccharomyces cerevisiae
Length: 373 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DSK2.

Description E-value Query
Range
Subject
Range
gi|786151, gi|13... - gi|786151|gb|AAB07267.1| ubiquitin-like protein [Saccharomyces cerevisiae], gi|1352321|sp|P48510.1|D...
3.0E-61 [1..373] [1..373]
gi|7715605, gi|2... - gi|7715605|gb|AAF68123.1|AC010793_18 F20B17.8 [Arabidopsis thaliana], pir||F96827 protein F20B17.8 [...
3.0E-60 [3..372] [1..364]
gi|5640111 - gi|5640111|emb|CAB51544.1| RAD23 protein [Solanum lycopersicum var. cerasiforme]
2.0E-58 [3..370] [1..382]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
9.0E-53 [3..370] [1..376]

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Predicted Domain #1
Region A:
Residues: [1-107]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLNIHIKSG QDKWEVNVAP ESTVLQFKEA INKANGIPVA NQRLIYSGKI LKDDQTVESY  60
   61 HIQDGHSVHL VKSQPKPQTA SAAGANNATA TGAAAGTGAT PNMSSGQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 110.703922
Match: 1bt0A_
Description: Rub1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 3.35791544110308 bayes_pls_golite062009
small conjugating protein ligase activity 1.83465130904364 bayes_pls_golite062009
protein binding 1.76858817153382 bayes_pls_golite062009
transcription regulator activity 1.42747465816672 bayes_pls_golite062009
nucleic acid binding 1.32707653701567 bayes_pls_golite062009
DNA binding 1.22622447288034 bayes_pls_golite062009
ubiquitin-protein ligase activity 1.16468510691469 bayes_pls_golite062009
tubulin binding 1.11505425062041 bayes_pls_golite062009
acid-amino acid ligase activity 0.919595189902044 bayes_pls_golite062009
cytoskeletal protein binding 0.907853439770547 bayes_pls_golite062009
microtubule binding 0.84012258724586 bayes_pls_golite062009
hydrolase activity 0.247201449341942 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [108-259]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SAGFNPLADL TSARYAGYLN MPSADMFGPD GGALNNDSNN QDELLRMMEN PIFQSQMNEM  60
   61 LSNPQMLDFM IQSNPQLQAM GPQARQMLQS PMFRQMLTNP DMIRQSMQFA RMMDPNAGMG 120
  121 SAGGAASAFP APGGDAPEEG SNTNTTSSSN TG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 2.9974054448593 bayes_pls_golite062009
DNA binding 2.7109101781315 bayes_pls_golite062009
nucleic acid binding 2.65801759476965 bayes_pls_golite062009
damaged DNA binding 2.33590042963509 bayes_pls_golite062009
transcription regulator activity 1.57741426576729 bayes_pls_golite062009
ubiquitin binding 1.38611607035372 bayes_pls_golite062009
small conjugating protein binding 1.25128759629714 bayes_pls_golite062009
protein binding 0.989474580552798 bayes_pls_golite062009
hydrolase activity 0.365329242181237 bayes_pls_golite062009
catalytic activity 0.2736776367506 bayes_pls_golite062009
peptidase activity 0.0113950255895392 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [260-329]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNAGTNAGTN AGANTAANPF ASLLNPALNP FANAGNAAST GMPAFDPALL ASMFQPPVQA  60
   61 SQAEDTRPPE 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [330-373]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ERYEHQLRQL NDMGFFDFDR NVAALRRSGG SVQGALDSLL NGDV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.30103
Match: 1f4iA_
Description: DNA repair protein Hhr23a
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle