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View Structure Prediction Details

Protein: DSK2
Organism: Saccharomyces cerevisiae
Length: 373 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DSK2.

Description E-value Query
Range
Subject
Range
gi|786151, gi|13... - gi|786151|gb|AAB07267.1| ubiquitin-like protein [Saccharomyces cerevisiae], gi|1352321|sp|P48510.1|D...
3.0E-61 [1..373] [1..373]
gi|7715605, gi|2... - gi|7715605|gb|AAF68123.1|AC010793_18 F20B17.8 [Arabidopsis thaliana], pir||F96827 protein F20B17.8 [...
3.0E-60 [3..372] [1..364]
gi|5640111 - gi|5640111|emb|CAB51544.1| RAD23 protein [Solanum lycopersicum var. cerasiforme]
2.0E-58 [3..370] [1..382]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
9.0E-53 [3..370] [1..376]

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Predicted Domain #1
Region A:
Residues: [1-107]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLNIHIKSG QDKWEVNVAP ESTVLQFKEA INKANGIPVA NQRLIYSGKI LKDDQTVESY  60
   61 HIQDGHSVHL VKSQPKPQTA SAAGANNATA TGAAAGTGAT PNMSSGQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 110.703922
Match: 1bt0A_
Description: Rub1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 3.35791544110308 bayes_pls_golite062009
small conjugating protein ligase activity 1.83465130904364 bayes_pls_golite062009
protein binding 1.76858817153382 bayes_pls_golite062009
transcription regulator activity 1.42747465816672 bayes_pls_golite062009
nucleic acid binding 1.32707653701567 bayes_pls_golite062009
DNA binding 1.22622447288034 bayes_pls_golite062009
ubiquitin-protein ligase activity 1.16468510691469 bayes_pls_golite062009
tubulin binding 1.11505425062041 bayes_pls_golite062009
acid-amino acid ligase activity 0.919595189902044 bayes_pls_golite062009
cytoskeletal protein binding 0.907853439770547 bayes_pls_golite062009
microtubule binding 0.84012258724586 bayes_pls_golite062009
hydrolase activity 0.247201449341942 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [108-259]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SAGFNPLADL TSARYAGYLN MPSADMFGPD GGALNNDSNN QDELLRMMEN PIFQSQMNEM  60
   61 LSNPQMLDFM IQSNPQLQAM GPQARQMLQS PMFRQMLTNP DMIRQSMQFA RMMDPNAGMG 120
  121 SAGGAASAFP APGGDAPEEG SNTNTTSSSN TG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 2.9974054448593 bayes_pls_golite062009
DNA binding 2.7109101781315 bayes_pls_golite062009
nucleic acid binding 2.65801759476965 bayes_pls_golite062009
damaged DNA binding 2.33590042963509 bayes_pls_golite062009
transcription regulator activity 1.57741426576729 bayes_pls_golite062009
ubiquitin binding 1.38611607035372 bayes_pls_golite062009
small conjugating protein binding 1.25128759629714 bayes_pls_golite062009
protein binding 0.989474580552798 bayes_pls_golite062009
hydrolase activity 0.365329242181237 bayes_pls_golite062009
catalytic activity 0.2736776367506 bayes_pls_golite062009
peptidase activity 0.0113950255895392 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [260-329]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNAGTNAGTN AGANTAANPF ASLLNPALNP FANAGNAAST GMPAFDPALL ASMFQPPVQA  60
   61 SQAEDTRPPE 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.519 a.60.2 RuvA domain 2-like
View Download 0.652 a.60.9 lambda integrase-like, N-terminal domain
View Download 0.571 a.4.11 RNA polymerase subunit RPB10
View Download 0.485 d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.569 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.443 a.4.1 Homeodomain-like
View Download 0.427 a.4.1 Homeodomain-like
View Download 0.404 a.60.3 C-terminal domain of RNA polymerase alpha subunit
View Download 0.383 a.4.1 Homeodomain-like
View Download 0.382 a.60.1 SAM/Pointed domain
View Download 0.368 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.357 a.4.1 Homeodomain-like
View Download 0.357 a.4.2 Methylated DNA-protein cysteine methyltransferase, C-terminal domain
View Download 0.357 a.4.1 Homeodomain-like
View Download 0.346 d.68.3 SirA-like
View Download 0.317 a.64.1 Saposin
View Download 0.313 d.58.1 4Fe-4S ferredoxins
View Download 0.312 a.17.1 p8-MTCP1
View Download 0.301 a.4.5 "Winged helix" DNA-binding domain
View Download 0.300 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.297 a.4.1 Homeodomain-like
View Download 0.294 d.42.1 POZ domain
View Download 0.289 a.74.1 Cyclin-like
View Download 0.279 a.60.5 Barrier-to-autointegration factor, BAF
View Download 0.278 a.60.2 RuvA domain 2-like
View Download 0.273 a.64.1 Saposin
View Download 0.272 a.60.6 DNA polymerase beta, N-terminal domain-like
View Download 0.272 a.4.5 "Winged helix" DNA-binding domain
View Download 0.269 a.36.1 Signal peptide-binding domain
View Download 0.259 a.51.1 Cytochrome c oxidase subunit h
View Download 0.254 a.4.5 "Winged helix" DNA-binding domain
View Download 0.253 a.70.1 N-terminal domain of the delta subunit of the F1F0-ATP synthase
View Download 0.249 a.144.1 PABC (PABP) domain
View Download 0.240 d.120.1 Cytochrome b5
View Download 0.232 d.68.7 R3H domain
View Download 0.231 d.42.1 POZ domain
View Download 0.216 a.21.1 HMG-box
View Download 0.202 g.15.1 Ovomucoid/PCI-1 like inhibitors

Predicted Domain #4
Region A:
Residues: [330-373]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ERYEHQLRQL NDMGFFDFDR NVAALRRSGG SVQGALDSLL NGDV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.30103
Match: 1f4iA_
Description: DNA repair protein Hhr23a
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle