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Protein Overview: SHE4

General Information:
Name(s) found: SHE4 / YOR035C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 789 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: intracellular mRNA localization [IMPLink to PubMed article]
    actin cytoskeleton organization [TASLink to PubMed article]
    gene conversion at mating-type locus [IMPLink to PubMed article]
    Molecular Function: myosin binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPLCEKGNDP IDSSTIDSLC AAFDKTLKST PDVQKYNDAI NTIFQLRQKS ESGKMPADLT  60
   61 NSEALKDRQK IEEILTRSYQ DHSESRVHLS KLIQNDIPFA LNLFEILSRS SIHVFVGCFS 120
  121 NKDATIALLN ELQIRIHYGE DTHVTYLLSI ILQLLNKFKY NFKEVRFLVK ELILRISEDE 180
  181 VKSMMLIIFA ELQSSFQKDF DKAVVDFMSS LIVEAEIDVG NDPLSIIVKT LSELYPSLTT 240
  241 LCSEIFLTKG LSKLFKKRVF EEQDLQFTKE LLRLLSSACI DETMRTYITE NYLQLLERSL 300
  301 NVEDVQIYSA LVLVKTWSFT KLTCINLKQL SEIFINAISR RIMPKIENVN ESAVKLEEVP 360
  361 KVEMSVEALA YLSLKASVKI MIRSNESFTE ILLTMIKSQK MTHCLYGLLV IMANLSTLPE 420
  421 ESNGSSQSIN DLKNYADLKG PGADKVGAEK ESKEDILLFN EKYILRTELI SFLKREMHNL 480
  481 SPNCKQQVVR VIYNITRSKN FIPQCISQGG TTIILEYLAN KQDIGEPIRI LGCRALTRML 540
  541 IFTNPGLIFK KYSALNAIPF LFELLPRSTP VDDNPLHNDE QIKLTDNYEA LLALTNLASS 600
  601 ETSDGEEVCK HIVSTKVYWS TIENLMLDEN VPLQRSTLEL ISNMMSHPLT IAAKFFNLEN 660
  661 PQSLRNFNIL VKLLQLSDVE SQRAVAAIFA NIATTIPLIA KELLTKKELI ENAIQVFADQ 720
  721 IDDIELRQRL LMLFFGLFEV IPDNGTNEVY PLLQENQKLK DALNMSLKRG DSGPEFSAAI 780
  781 PVILAKIKV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) MYO2 SHE4
    View Details Krogan NJ, et al. (2006) ATG33 BUB1 CUL3 GUT1 ISM1 MEC3 MLC1 MYO2 MYO4 RGA1 RSB1 SAT4 SHE2 SHE3 SHE4 SRC1 SSH4 STT4 TOF2 TVP18 YDR186C YOL098C
    View Details Gavin AC, et al. (2006) MYO2 SHE4
    View Details Gavin AC, et al. (2002) CMD1 CSL4 CTR9 DIS3 ECM16 GCN1 MAM33 MLC1 MTR3 MYO2 NMD5 RRP4 RRP40 RRP42 RRP43 RRP45 RRP46 RRP6 SAM1 SHE4 SKI6 SKI7 SRP1 UTP10
    View Details Ho Y, et al. (2002) CMD1 CMP2 HUL5 MLC1 MYO2 MYO3 MYO4 MYO5 SHE4 SPC110

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SHE4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..659] deduced N/A No confident structure predictions are available.
    2 View Details [660..789] ORFEUS 14.83 Constant regulatory domain of protein phosphatase 2a, pr65alpha

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.17307898957054 bayes_pls_golite062009
  • protein binding
    		•  1.63424405980235 bayes_pls_golite062009
  • protein transporter activity
    		•  1.42296231035293 bayes_pls_golite062009
  • transporter activity
    		•  0.714933767255544 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.395596656069974 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.36250570104201 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.187924119511902 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.89

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle