YRC Public Data Repository - Protein Structure Prediction

Protein:	SHE4
Organism:	Saccharomyces cerevisiae
Length:	789 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SHE4.

Description	E-value	Query Range	Subject Range
SHE4_YEAST - SWI5-dependent HO expression protein 4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=S... SHE4 - Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin...	0.0	[1..789]	[1..789]
gi\|171689208 - gi\|171689208\|ref\|XP_001909544.1\| unnamed protein product [Podospora anserina] gi\|170944566, gi... - gi\|2808541\|emb\|CAA76144.1\| CRO1 protein [Podospora anserina], gi\|170944566\|emb\|CAP70677.1\| unnamed p...	0.0	[234..732]	[136..646]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[234..748]	[141..667]
gi\|18375983 - gi\|18375983\|emb\|CAB91722.2\| probable cro1 protein [Neurospora crassa] gi\|157070582, gi... - gi\|164424601\|ref\|XP_963662.2\| hypothetical protein NCU06821 [Neurospora crassa OR74A], gi\|157070582\|...	0.0	[234..748]	[141..673]
UNC45A - unc-45 homolog A (C. elegans) gi\|123999240, gi... - gi\|123999240\|gb\|ABM87199.1\| unc-45 homolog A (C. elegans) [synthetic construct], gi\|123989495\|gb\|ABM...	0.0	[304..779]	[478..924]
gi\|19527172, gi\|... - gi\|19527172\|ref\|NP_598713.1\| smooth muscle cell associated protein-1 [Mus musculus], gi\|148675058\|gb...	0.0	[304..779]	[478..924]
gi\|4104168 - gi\|4104168\|gb\|AAD01960.1\| UNC-45 [Caenorhabditis briggsae]	0.0	[266..729]	[440..883]

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Predicted Domain #1

Region A:
Residues: [1-659]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPLCEKGNDP IDSSTIDSLC AAFDKTLKST PDVQKYNDAI NTIFQLRQKS ESGKMPADLT  60
   61 NSEALKDRQK IEEILTRSYQ DHSESRVHLS KLIQNDIPFA LNLFEILSRS SIHVFVGCFS 120
  121 NKDATIALLN ELQIRIHYGE DTHVTYLLSI ILQLLNKFKY NFKEVRFLVK ELILRISEDE 180
  181 VKSMMLIIFA ELQSSFQKDF DKAVVDFMSS LIVEAEIDVG NDPLSIIVKT LSELYPSLTT 240
  241 LCSEIFLTKG LSKLFKKRVF EEQDLQFTKE LLRLLSSACI DETMRTYITE NYLQLLERSL 300
  301 NVEDVQIYSA LVLVKTWSFT KLTCINLKQL SEIFINAISR RIMPKIENVN ESAVKLEEVP 360
  361 KVEMSVEALA YLSLKASVKI MIRSNESFTE ILLTMIKSQK MTHCLYGLLV IMANLSTLPE 420
  421 ESNGSSQSIN DLKNYADLKG PGADKVGAEK ESKEDILLFN EKYILRTELI SFLKREMHNL 480
  481 SPNCKQQVVR VIYNITRSKN FIPQCISQGG TTIILEYLAN KQDIGEPIRI LGCRALTRML 540
  541 IFTNPGLIFK KYSALNAIPF LFELLPRSTP VDDNPLHNDE QIKLTDNYEA LLALTNLASS 600
  601 ETSDGEEVCK HIVSTKVYWS TIENLMLDEN VPLQRSTLEL ISNMMSHPLT IAAKFFNLE

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
binding	2.17307898957054	bayes_pls_golite062009
protein binding	1.63424405980235	bayes_pls_golite062009
protein transporter activity	1.42296231035293	bayes_pls_golite062009
transporter activity	0.714933767255544	bayes_pls_golite062009
nucleic acid binding	0.395596656069974	bayes_pls_golite062009
substrate-specific transporter activity	0.36250570104201	bayes_pls_golite062009
cytoskeletal protein binding	0.187924119511902	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [660-789]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPQSLRNFNI LVKLLQLSDV ESQRAVAAIF ANIATTIPLI AKELLTKKEL IENAIQVFAD  60
   61 QIDDIELRQR LLMLFFGLFE VIPDNGTNEV YPLLQENQKL KDALNMSLKR GDSGPEFSAA 120
  121 IPVILAKIKV

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	14.83
Match:	1b3uA
Description:	Constant regulatory domain of protein phosphatase 2a, pr65alpha
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: