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Protein Overview: UNC45A

General Information:
Name(s) found: UNC45A [HGNC (HUGO)]
Description(s) found:
Found 34 descriptions.
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  • unc-45 homolog A (C. elegans) [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 944 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTVSGPGTPE PRPATPGASS VEQLRKEGNE LFKCGDYGGA LAAYTQALGL DATPQDQAVL  60
   61 HRNRAACHLK LEDYDKAETE ASKAIEKDGG DVKALYRRSQ ALEKLGRLDQ AVLDLQRCVS 120
  121 LEPKNKVFQE ALRNIGGQIQ EKVRYMSSTD AKVEQMFQIL LDPEEKGTEK KQKASQNLVV 180
  181 LAREDAGAEK IFRSNGVQLL QRLLDMGETD LMLAALRTLV GICSEHQSRT VATLSILGTR 240
  241 RVVSILGVES QAVSLAACHL LQVMFDALKE GVKKGFRGKE GAIIVDPARE LKVLISNLLD 300
  301 LLTEVGVSGQ GRDNALTLLI KAVPRKSLKD PNNSLTLWVI DQGLKKILEV GGSLQDPPGE 360
  361 LAVTANSRMS ASILLSKLFD DLKCDAEREN FHRLCENYIK SWFEGQGLAG KLRAIQTVSC 420
  421 LLQGPCDAGN RALELSGVME SVIALCASEQ EEEQLVAVEA LIHAAGKAKR ASFITANGVS 480
  481 LLKDLYKCSE KDSIRIRALV GLCKLGSAGG TDFSMKQFAE GSTLKLAKQC RKWLCNDQID 540
  541 AGTRRWAVEG LAYLTFDADV KEEFVEDAAA LKALFQLSRL EERSVLFAVA SALVNCTNSY 600
  601 DYEEPDPKMV ELAKYAKQHV PEQHPKDKPS FVRARVKKLL AAGVVSAMVC MVKTESPVLT 660
  661 SSCRELLSRV FLALVEEVED RGTVVAQGGG RALIPLALEG TDVGQTKAAQ ALAKLTITSN 720
  721 PEMTFPGERI YEVVRPLVSL LHLNCSGLQN FEALMALTNL AGISERLRQK ILKEKAVPMI 780
  781 EGYMFEEHEM IRRAATECMC NLAMSKEVQD LFEAQGNDRL KLLVLYSGED DELLQRAAAG 840
  841 GLAMLTSMRP TLCSRIPQVT THWLEILQAL LLSSNQELQH RGAVVVLNMV EASREIASTL 900
  901 MESEMMEILS VLAKGDHSPV TRAAAACLDK AVEYGLIQPN QDGE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..139] PSI-BLAST 19.69897 No description for 2dbaA was found.
    2 View Details [140..448] FFAS03 2.38 Crystal structure of the exportin Cse1p complexed with its cargo ( Kap60p) and RanGTP
    3 View Details [449..944] PSI-BLAST 49.0 THE ARMADILLO REPEAT REGION FROM MURINE BETA-CATENIN

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  2.33303322187387 bayes_pls_golite062009
  • protein binding
    		•  1.5114863464349 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.875976248365647 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.73539719922204 bayes_pls_golite062009
  • actin binding
    		•  0.552558582632569 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.242964024046384 bayes_pls_golite062009
    3
    Term Confidence Notes
  • binding
    		•  2.4389817190572 bayes_pls_golite062009
  • protein binding
    		•  1.63705839411934 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.01396453014861 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.773975545005505 bayes_pls_golite062009
  • actin binding
    		•  0.572473732371314 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.294257360897755 bayes_pls_golite062009
  • RNA binding
    		•  0.0287526191298597 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle