YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: TOF2

General Information:
Name(s) found: TOF2 / YKR010C [SGD]
Description(s) found:
Found 30 descriptions.
SHOW ALL
  • Protein required for rDNA silencing and mitotic rDNA condensation; stimulates Cdc14p phosphatase activity and biphasic release to promote rDNA repeat segregation; required for condensin recruitment to the replication fork barrier site [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 771 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Biological Process: DNA topological change [IPILink to PubMed article]
    Molecular Function: molecular_function [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIKMWRLQIV LVPPSAQDII TFLEARLNTP QSVSPMVQYN EDIITHNNSI NNCSDPSPTS  60
   61 PSSQNSIQSN RSSDFINYLP NCKKFLHFTD GDNTLLQLSN EILTKFDRLY PNFKESIEIV 120
  121 SLQDRHGCDL DSEFIIKDVF ENDGVVLVIL KDELDWSRNQ HISLLQLARQ RRRQDNKPST 180
  181 KSIVTEKRKK ISKEDLSSIS NKDTMHLIAK SSLKNNFINK SRVSTPLMNE ILPLASKYDA 240
  241 LNKEKCPMPL TSTVVASNVH KDVKDHARAK EGVVTQGSDN NKENIPSSTQ QQKNDGAKRA 300
  301 ESKDLDLLRN SSEDADYEPA DENSPQISFD SIDTDFQLST TSHTNSDMHI QYSNPSSGAH 360
  361 SPRKSSLEIK VQNKKGDDLP LNDKDIGENC RRIEAFSDEE DFNETDNDRA DSFINNSKKA 420
  421 SMGFRDINSD LDSVSFNSDI ENAVQSTQST KNVVSPPFFP EKELNNRLHQ SQGKEALFRL 480
  481 VEKEFPDKSL GAASSTSHAK DVKIQETIRK LNRFKPTGET KVQKRNSITE PYYGKFGIMK 540
  541 KDKPKSITSK GVSLETKHFD DPNTIISGEK FAKFGKIKVK RKTDDVGSKV IEFKRKRNMG 600
  601 NRSLKDIFAN AGKPPNAAST IKVVKLMRDP VDNSKDKVEA TSNSTAQEQE QVSPKLPVMN 660
  661 STPGKRKNGQ AIPSSLERTP QLKKVKVTRS HSSPSSSSSM SLESSLDSSS SDDSDDDSDS 720
  721 RNVQVKKINF KTSHGPAGNS NGKPMLDVDD NEINTKKYQT PKYVESDEDD Q

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ATG33 BUB1 CUL3 GUT1 ISM1 MEC3 MLC1 MYO2 MYO4 RGA1 RSB1 SAT4 SHE2 SHE3 SHE4 SRC1 SSH4 STT4 TOF2 TVP18 YDR186C YOL098C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #04 Alpha Factor Prep2 Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data TOF2 Huh WK, et al. (2003)
    View Data TOF2 and NOP56 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..241] MSA 1.002935 View MSA. No confident structure predictions are available.
    2 View Details [242..771] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.78

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle