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Protein Overview: CUL3

General Information:
Name(s) found: CUL3 / YGR003W [SGD]
Description(s) found:
Found 27 descriptions.
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  • Ubiquitin-protein ligase, member of the cullin family with similarity to Cdc53p and human CUL3; required for ubiquitin-dependent degredation of the RNA Polymerase II subunit RPO21 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 744 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Cul3-RING ubiquitin ligase complex [IMPLink to PubMed article]
    Biological Process: protein ubiquitination during ubiquitin-dependent protein catabolic process [IMPLink to PubMed article]
    ubiquitin-dependent protein catabolic process [ICLink to PubMed article][ISSLink to PubMed article]
    Molecular Function: ubiquitin-protein ligase activity [IDALink to PubMed article]
    protein binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MITNKKIKIS VPEKLGLSEE SFEESWETVK YAIDHIYSDD MADLSFEQVY KTIYTIVLNK  60
   61 KGPILYNRLK DYLIQKLALL RETIVKDNTH DYEFLGTMAR LWEVQCHCFK ITGDLMMYMD 120
  121 KVYCKPNRCM EVYDMCLDLF RIEILQKCSS SLISALISDI ERIRNLGSVD SEHTSLWKVL 180
  181 IGMMETLHDN RDSFFLTDFE PVLISATEEY YNKAIDIELL TPIESLEKIR KLRQFESMLD 240
  241 SSFLNVDSHN KLKTVLENVL IWGKLSDIIE DLTHEAMVIS NGKLLQEIYD LSSEEKYRVT 300
  301 VIESIKSYIN KNAINIPFNE GNRKKGQNAI TWSSEIVELY RSQHSFLESI DFGSVRLNNL 360
  361 TGDVSNAILG DVFSMYFSKE GALPSEYLST YVDHCMKRTK EKDAEIVKIK QDLLDSTKLI 420
  421 GLLTEKDIFE KIYKKQLSRR LLQQRSLVEI EKWMVQMIKK VLGTFFTSKL EIMLRDISLS 480
  481 SEMYQAFQHS TINSIEYLSF APQVLTRTSW PFQSTNPIDE GISLPPRMSQ ILAGFEGYYS 540
  541 LKYKERVLKW AHHLSVIEIG CQFNSGYYEI SFSVYAGVIF LLFEDYEELT LGEIYELTHI 600
  601 PIDDVKSLVM SMSTIPRCKI LKKSSSSGNM KFSVNYFFSS PNRKVKVPVI ACPLPSQKSD 660
  661 NLATASSVDT YDNEIVMELS AIIVRIMKTE GKLSHQQLLE RTTKRTQSRL SLTPSILKRS 720
  721 IQLLIEKEYI QRNADDPSYY HYLS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ATG33 BUB1 CUL3 GUT1 ISM1 MEC3 MLC1 MYO2 MYO4 RGA1 RSB1 SAT4 SHE2 SHE3 SHE4 SRC1 SSH4 STT4 TOF2 TVP18 YDR186C YOL098C

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CUL3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..74]
    [107..134]    		 PSI-BLAST 1322.218487 Anaphase promoting complex (APC); Cullin homolog 1, Cul-1; Cullin homolog 1, cul-1
    2 View Details [75..106]
    [135..271]
    [285..298]    		 PSI-BLAST 1322.218487 Anaphase promoting complex (APC); Cullin homolog 1, Cul-1; Cullin homolog 1, cul-1
    3 View Details [272..284]
    [299..477]    		 PSI-BLAST 1322.218487 Anaphase promoting complex (APC); Cullin homolog 1, Cul-1; Cullin homolog 1, cul-1
    4 View Details [478..551] PSI-BLAST 1322.218487 Anaphase promoting complex (APC); Cullin homolog 1, Cul-1; Cullin homolog 1, cul-1
    5 View Details [552..670] PSI-BLAST 1322.218487 Anaphase promoting complex (APC); Cullin homolog 1, Cul-1; Cullin homolog 1, cul-1
    6 View Details [671..744] PSI-BLAST 1322.218487 Anaphase promoting complex (APC); Cullin homolog 1, Cul-1; Cullin homolog 1, cul-1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  9.95820721075934 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  9.63704265478699 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  8.59660059921406 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  7.32718329074249 bayes_pls_golite062009
  • transcription regulator activity
    		•  4.76121492612224 bayes_pls_golite062009
  • transcription factor activity
    		•  3.7855017556511 bayes_pls_golite062009
  • ligase activity
    		•  3.6057341267609 bayes_pls_golite062009
  • binding
    		•  2.45185337633142 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.39237599101586 bayes_pls_golite062009
  • protein binding
    		•  2.34145982999922 bayes_pls_golite062009
  • vasopressin activated calcium mobilizing receptor activity
    		•  2.2896527918019 bayes_pls_golite062009
  • transcription activator activity
    		•  2.05043065144612 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.54797684894025 bayes_pls_golite062009
  • DNA binding
    		•  1.42215436462553 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.23862224095769 bayes_pls_golite062009
  • transporter activity
    		•  0.891050405674973 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.648150681919233 bayes_pls_golite062009
  • transcription factor binding
    		•  0.612315945412079 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.368917395770011 bayes_pls_golite062009
  • catalytic activity
    		•  0.351553138703956 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.249771970501337 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.146182977030285 bayes_pls_golite062009
  • hydrolase activity
    		•  0.140191206949582 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.117670813298683 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.107671044044222 bayes_pls_golite062009
  • transferase activity
    		•  0.064832527337659 bayes_pls_golite062009
  • specific transcriptional repressor activity
    		•  0.0565989703351002 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.0102780098866235 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle