YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: CUL3
Organism: Saccharomyces cerevisiae
Length: 744 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CUL3.

Description E-value Query
Range		 Subject
Range
gi|13259127 - gi|13259127|gb|AAK16812.1|AF212995_1 cullin CUL4B [Homo sapiens]
 0.0 [5..744] [62..782]
CUL1_ARATH - Cullin-1 OS=Arabidopsis thaliana GN=CUL1 PE=1 SV=1
 0.0 [17..744] [3..738]
CUL3_MOUSE - Cullin-3 OS=Mus musculus GN=Cul3 PE=1 SV=1
 0.0 [6..744] [15..768]
gi|14091836 - gi|14091836|gb|AAK53839.1|AC011806_16 Putative cullin [Oryza sativa]
gi|125570399 - gi|125570399|gb|EAZ11914.1| hypothetical protein OsJ_001739 [Oryza sativa (japonica cultivar-group)]
 0.0 [17..744] [6..750]

Back

Predicted Domain #1
Region A:
Residues: [1-74] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MITNKKIKIS VPEKLGLSEE SFEESWETVK YAIDHIYSDD MADLSFEQVY KTIYTIVLNK  60
   61 KGPILYNRLK DYLI

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [107-134] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HCFKITGDLM MYMDKVYCKP NRCMEVYD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1322.218487
Match: 1ldjA_
Description: Anaphase promoting complex (APC); Cullin homolog 1, Cul-1; Cullin homolog 1, cul-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 9.95820721075934 bayes_pls_golite062009
small conjugating protein ligase activity 9.63704265478699 bayes_pls_golite062009
acid-amino acid ligase activity 8.59660059921406 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 7.32718329074249 bayes_pls_golite062009
transcription regulator activity 4.76121492612224 bayes_pls_golite062009
transcription factor activity 3.7855017556511 bayes_pls_golite062009
ligase activity 3.6057341267609 bayes_pls_golite062009
binding 2.45185337633142 bayes_pls_golite062009
transcription repressor activity 2.39237599101586 bayes_pls_golite062009
protein binding 2.34145982999922 bayes_pls_golite062009
vasopressin activated calcium mobilizing receptor activity 2.2896527918019 bayes_pls_golite062009
transcription activator activity 2.05043065144612 bayes_pls_golite062009
nucleic acid binding 1.54797684894025 bayes_pls_golite062009
DNA binding 1.42215436462553 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.23862224095769 bayes_pls_golite062009
transporter activity 0.891050405674973 bayes_pls_golite062009
transmembrane transporter activity 0.648150681919233 bayes_pls_golite062009
transcription factor binding 0.612315945412079 bayes_pls_golite062009
substrate-specific transporter activity 0.368917395770011 bayes_pls_golite062009
catalytic activity 0.351553138703956 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.249771970501337 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.146182977030285 bayes_pls_golite062009
hydrolase activity 0.140191206949582 bayes_pls_golite062009
structure-specific DNA binding 0.117670813298683 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.107671044044222 bayes_pls_golite062009
transferase activity 0.064832527337659 bayes_pls_golite062009
specific transcriptional repressor activity 0.0565989703351002 bayes_pls_golite062009
sequence-specific DNA binding 0.0102780098866235 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [75-106] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QKLALLRETI VKDNTHDYEF LGTMARLWEV QC

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [135-271] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCLDLFRIEI LQKCSSSLIS ALISDIERIR NLGSVDSEHT SLWKVLIGMM ETLHDNRDSF  60
   61 FLTDFEPVLI SATEEYYNKA IDIELLTPIE SLEKIRKLRQ FESMLDSSFL NVDSHNKLKT 120
  121 VLENVLIWGK LSDIIED

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [285-298] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LQEIYDLSSE EKYR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1322.218487
Match: 1ldjA_
Description: Anaphase promoting complex (APC); Cullin homolog 1, Cul-1; Cullin homolog 1, cul-1
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [272-284] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTHEAMVISN GKL

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [299-477] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VTVIESIKSY INKNAINIPF NEGNRKKGQN AITWSSEIVE LYRSQHSFLE SIDFGSVRLN  60
   61 NLTGDVSNAI LGDVFSMYFS KEGALPSEYL STYVDHCMKR TKEKDAEIVK IKQDLLDSTK 120
  121 LIGLLTEKDI FEKIYKKQLS RRLLQQRSLV EIEKWMVQMI KKVLGTFFTS KLEIMLRDI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1322.218487
Match: 1ldjA_
Description: Anaphase promoting complex (APC); Cullin homolog 1, Cul-1; Cullin homolog 1, cul-1
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [478-551] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLSSEMYQAF QHSTINSIEY LSFAPQVLTR TSWPFQSTNP IDEGISLPPR MSQILAGFEG  60
   61 YYSLKYKERV LKWA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1322.218487
Match: 1ldjA_
Description: Anaphase promoting complex (APC); Cullin homolog 1, Cul-1; Cullin homolog 1, cul-1
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [552-670] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HHLSVIEIGC QFNSGYYEIS FSVYAGVIFL LFEDYEELTL GEIYELTHIP IDDVKSLVMS  60
   61 MSTIPRCKIL KKSSSSGNMK FSVNYFFSSP NRKVKVPVIA CPLPSQKSDN LATASSVDT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1322.218487
Match: 1ldjA_
Description: Anaphase promoting complex (APC); Cullin homolog 1, Cul-1; Cullin homolog 1, cul-1
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [671-744] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YDNEIVMELS AIIVRIMKTE GKLSHQQLLE RTTKRTQSRL SLTPSILKRS IQLLIEKEYI  60
   61 QRNADDPSYY HYLS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1322.218487
Match: 1ldjA_
Description: Anaphase promoting complex (APC); Cullin homolog 1, Cul-1; Cullin homolog 1, cul-1
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle