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Protein Overview: MYO3

General Information:
Name(s) found: MYO3 / YKL129C [SGD]
Description(s) found:
Found 18 descriptions.
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  • One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1271 amino acids

    Gene Ontology:
    Cellular Component: actin cortical patch [IPILink to PubMed article]
    Biological Process: bipolar cellular bud site selection [IMPLink to PubMed article]
    response to osmotic stress [IMPLink to PubMed article]
    cellular cell wall organization [IMPLink to PubMed article]
    endocytosis [IMPLink to PubMed article]
    exocytosis [IMPLink to PubMed article]
    Molecular Function: microfilament motor activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVIKKGARR KDVKEPKKRS AKIKKATFDA NKKKEVGISD LTLLSKISDE SINENLKKRF  60
   61 KNGIIYTYIG HVLISVNPFR DLGIYTNAVL ESYKGKNRLE VPPHVFAIAE SMYYNLKSYN 120
  121 ENQCVIISGE SGAGKTEAAK RIMQYIAAAS NSHSESIGKI KDMVLATNPL LESFGCAKTL 180
  181 RNNNSSRHGK YLEIKFNSQF EPCAGNITNY LLEKQRVVGQ IKNERNFHIF YQFTKGASDT 240
  241 YKQMFGVQMP EQYIYTAAAG CTSADQLMRK DYEGTLEAMR TIGLVQEEQD QIFRMLAAIL 300
  301 WIGNISFIEN EEGNAQVGDT SVTDFVAYLL QVDASLLVKC LVERIMQTSH GMKRGSVYHV 360
  361 PLNPVQATAV RDALAKAIYN NLFDWIVDRV NVSLQAFPGA DKSIGILDIY GFEIFEHNSF 420
  421 EQICINYVNE KLQQIFIQLT LKAEQETYER EKIKWTPIKY FDNKVVCDLI EAKNPPGILA 480
  481 AMNDSIATAH ADSNAADQAF AQRLNLFNSN PYFELRANKF VIKHYAGDVT YDINGITDKN 540
  541 KDQLQKDLIE LIGTTTNTFL STIFPDDVDK DSKRRPPTAG DKIIKSANEL VETLSKAEPS 600
  601 YIRTIKPNQT KSPNDYDDHQ VLHQVKYLGL QENVRIRRAG FAYRQTFEKF VERFYLLSPD 660
  661 CSYAGDYTWD GDTLEAVKLI LRDAMIPEKE FQLGVTSVFI KTPESLFALE DMRDKYWYNM 720
  721 AARIQRAWRR FLQRRIDAAI KIQRTIREKK GGNKYVKLRD YGTKLLAGKK ERRSMSLLGY 780
  781 RAFMGDYLSC NESKTKGSYI RRQVGIKDKV VFSIKGECLH SKFGRSAQRL KKVFILTKKT 840
  841 FYIIGQTREQ NAMKYTQDYK IDVGKIKQVS LTNLQDDWMG VILVNSTQSD PLINTPFKTE 900
  901 LMTRLKKLNE KIMIKVGPTI EYHKQPNKLH TVRSKISDSA PKYGDIYKSS TIYVRRGHPA 960
  961 NSKSNKKPKN PGGLSGKPIK SKKSKHKSTH KHTHSHRSHR DAAKKQPLPS QKPVNPLSLR1020
 1021 ATAAQAAYNP KPDKTVPIKS SAIPAAKVSS KHSSKPSSKE KVAVKKASSS HKSSSAKQNQ1080
 1081 VSMPPSKGVE KNKEPLKETT ATATANIPIP PPPPPMGQPK DPKFEAAYDF PGSGSSSELP1140
 1141 LKKGDIVFIS RDEPSGWSLA KLLDGSKEGW VPTAYMTPYK DTRNTVPVAA TGAVNDVTNQ1200
 1201 KSSQIDNTIS SAQEGVQFGS ATVGPTSDNQ SNPVGTFSDG LASALAARAN KMRAESADDD1260
 1261 DNDDGDDDDD W

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CMD1 KEL2 MYO3
    View Details (MIPS) Mewes HW, et al. (2004) MYO1 MYO2 MYO3 MYO4 MYO5 SMY1 SMY2
    View Details Krogan NJ, et al. (2006) CMD1 CMK1 CMK2 CMP2 CNA1 CNB1 MYO3 MYO5 YGL242C
    View Details Ho Y, et al. (2002) CMD1 CMP2 HUL5 MLC1 MYO2 MYO3 MYO4 MYO5 SHE4 SPC110
    View Details Qiu et al. (2008) ABP1 AIP1 BZZ1 CAP1 CAP2 DYN1 MYO1 MYO2 MYO3 MYO4 MYO5 PAN1 RVS167 SLA1 SRV2 TWF1 VRP1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MYO3 Huh WK, et al. (2003)
    View Data MYO3 and SAC6 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..641] PSI-BLAST 2600.0 Myosin S1, motor domain
    2 View Details [642..713] PSI-BLAST 2600.0 Myosin S1, motor domain
    3 View Details [714..776] PSI-BLAST 12.69897 SCALLOP MYOSIN REGULATORY DOMAIN
    4 View Details [777..1097] PSI-BLAST 5.522879 Fibrinogen
    5 View Details [1098..1189] PSI-BLAST 11.154902 Growth factor receptor-bound protein 2 (GRB2), N- and C-terminal domains
    6 View Details [1190..1271] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • actin-dependent ATPase activity
    		•  5.83616693706338 bayes_pls_golite062009
  • microfilament motor activity
    		•  5.82833334737708 bayes_pls_golite062009
  • microtubule motor activity
    		•  4.51968578934603 bayes_pls_golite062009
  • motor activity
    		•  4.04927796049806 bayes_pls_golite062009
  • actin binding
    		•  3.33639699088484 bayes_pls_golite062009
  • transporter activity
    		•  3.10463051760206 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.95886887664984 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.95079405147356 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.87427509025394 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.85499564954033 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.85178667290149 bayes_pls_golite062009
  • tubulin binding
    		•  2.67743463093593 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  2.61775212528604 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  2.61467977505707 bayes_pls_golite062009
  • microtubule binding
    		•  2.59155206524122 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  2.57552435627908 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  2.57107347424517 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  2.57054427875021 bayes_pls_golite062009
  • hydrolase activity
    		•  2.55157966585974 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  2.50494515048649 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  2.43862163407966 bayes_pls_golite062009
  • ADP binding
    		•  2.42564874799906 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.4101693596493 bayes_pls_golite062009
  • ATPase activity
    		•  2.39535714892224 bayes_pls_golite062009
  • actin filament binding
    		•  2.24723363507804 bayes_pls_golite062009
  • myosin light chain binding
    		•  2.23966366728473 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.91091452720653 bayes_pls_golite062009
  • alpha-tubulin binding
    		•  1.792591628112 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.56325751172863 bayes_pls_golite062009
  • signal recognition particle binding
    		•  1.51332809264918 bayes_pls_golite062009
  • plus-end-directed microtubule motor activity
    		•  1.38366133153678 bayes_pls_golite062009
  • protein binding
    		•  1.22129154759482 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.977237423302079 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.960508657568442 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.929901285538132 bayes_pls_golite062009
  • nucleotide binding
    		•  0.922442819194247 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.920987930180051 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.920926158369519 bayes_pls_golite062009
  • GTPase activity
    		•  0.83849854735032 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.775560967092349 bayes_pls_golite062009
  • beta-tubulin binding
    		•  0.654735466720932 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  0.640772201693186 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  0.63468044350616 bayes_pls_golite062009
  • GTP binding
    		•  0.621689261700018 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.557919489256916 bayes_pls_golite062009
  • protein transporter activity
    		•  0.498432226280822 bayes_pls_golite062009
  • microtubule-severing ATPase activity
    		•  0.491769258942331 bayes_pls_golite062009
  • DNA binding
    		•  0.479412476059825 bayes_pls_golite062009
  • ATP binding
    		•  0.41092997612902 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.385813421701492 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.377870145186619 bayes_pls_golite062009
  • minus-end directed microfilament motor activity
    		•  0.329356138573379 bayes_pls_golite062009
  • plus-end directed microfilament motor activity
    		•  0.329356138573379 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.312171320541728 bayes_pls_golite062009
  • signal transducer activity
    		•  0.286367085584159 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.286367085584159 bayes_pls_golite062009
  • myosin binding
    		•  0.274885859454447 bayes_pls_golite062009
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•  0.213018989352421 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  0.169034229773346 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  0.123304946374679 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  0.0775601177068852 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.0111338193708552 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.0102645529518819 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle