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Protein Overview: CMK1

General Information:
Name(s) found: CMK1 / YFR014C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk2p and mammalian Cam Kinase II [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 446 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IPILink to PubMed article]
    Biological Process: signal transduction [IMPLink to PubMed article]
    protein amino acid phosphorylation [IDALink to PubMed article]
    Molecular Function: adenosine deaminase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDDKVSEKES SPKQTEEDSE GKMAHVQPAS YVNKKKYVFG KTLGAGTFGV VRQAKNTETG  60
   61 EDVAVKILIK KALKGNKVQL EALYDELDIL QRLHHPNIVA FKDWFESKDK FYIITQLAKG 120
  121 GELFDRILKK GKFTEEDAVR ILVEILSAVK YMHSQNIVHR DLKPENLLYI DKSDESPLVV 180
  181 ADFGIAKRLK SDEELLYKPA GSLGYVAPEV LTQDGHGKPC DIWSIGVITY TLLCGYSAFR 240
  241 AERVQDFLDE CTTGEYPVKF HRPYWDSVSN KAKQFILKAL NLDPSKRPTA AELLEDPWII 300
  301 CTELKTHNLL PGLKEGLDAR QKFRNSVERV RLNMKIQKLR DLYLEQTESD SDFDEGSQAN 360
  361 GSVPPLKATD TSQLSKKLSE EEQSKLKSEL TSKAFAQLVN TVLAEKEKFL NINRVCSSDS 420
  421 DLPGSDIKSL DEAKEKPEGK DTKTEE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CMD1 CMK1 CMK2 CMP2 CNA1 CNB1 MYO3 MYO5 YGL242C
    View Details Ho Y, et al. (2002) CMD1 CMK1 VPH2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ASF1 sample 3121 run on DecaLCQ: searched for phosphorylation Green EM, et al (2005)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CMK1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..120]
    [321..344]    		 PSI-BLAST 729.0 Calmodulin-dependent protein kinase
    2 View Details [121..320] PSI-BLAST 729.0 Calmodulin-dependent protein kinase
    3 View Details [345..446] PSI-BLAST 10.0 Calmodulin


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle