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Protein Overview: CNB1

General Information:
Name(s) found: CNB1 / YKL190W [SGD]
Description(s) found:
Found 37 descriptions.
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  • Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 175 amino acids

    Gene Ontology:
    Cellular Component: calcineurin complex [IPILink to PubMed articleLink to PubMed article]
    cytoplasm [ISSLink to PubMed article]
    Biological Process: cellular cell wall organization [IGILink to PubMed article][IMPLink to PubMed article]
    adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion [IMPLink to PubMed article]
    cellular ion homeostasis [IMPLink to PubMed article]
    Molecular Function: calcium-dependent protein serine/threonine phosphatase activity [IPILink to PubMed article][ISSLink to PubMed article]
    calcium ion binding [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGAAPSKIVD GLLEDTNFDR DEIERLRKRF MKLDRDSSGS IDKNEFMSIP GVSSNPLAGR  60
   61 IMEVFDADNS GDVDFQEFIT GLSIFSGRGS KDEKLRFAFK IYDIDKDGFI SNGELFIVLK 120
  121 IMVGSNLDDE QLQQIVDRTI VENDSDGDGR LSFEEFKNAI ETTEVAKSLT LQYDV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CMP2 CNB1
    View Details (MIPS) Mewes HW, et al. (2004) CMP2 CNA1 CNB1
    View Details Krogan NJ, et al. (2006) CMD1 CMK1 CMK2 CMP2 CNA1 CNB1 MYO3 MYO5 YGL242C
    View Details Ho Y, et al. (2002) CMP2 CNA1 CNB1 KRE6
    View Details Qiu et al. (2008) CMP2 CNA1 CNB1 PPH21

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CNB1 DML1 2 Uetz P, et al. (2000)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CNB1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..86] PSI-BLAST 490.917458 Calcineurin regulatory subunit (B-chain)
    2 View Details [87..175] PSI-BLAST 490.917458 Calcineurin regulatory subunit (B-chain)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphoprotein phosphatase activity
    		•  7.47426847861728 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  6.37104157544514 bayes_pls_golite062009
  • phosphatase activity
    		•  6.28157965296365 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  6.17799259119197 bayes_pls_golite062009
  • N-terminal myristoylation domain binding
    		•  5.746886320739 bayes_pls_golite062009
  • calcium-dependent protein serine/threonine phosphatase activity
    		•  5.58369939851095 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  5.11186887221409 bayes_pls_golite062009
  • calcium-dependent protein serine/threonine phosphatase regulator activity
    		•  4.70715233640875 bayes_pls_golite062009
  • calcium ion binding
    		•  3.79609619542776 bayes_pls_golite062009
  • structural constituent of muscle
    		•  3.55596144884703 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  3.49668552859347 bayes_pls_golite062009
  • motor activity
    		•  3.25814691068414 bayes_pls_golite062009
  • binding
    		•  3.17556402087346 bayes_pls_golite062009
  • G-protein beta/gamma-subunit binding
    		•  3.05549386641848 bayes_pls_golite062009
  • actin binding
    		•  2.93015079033749 bayes_pls_golite062009
  • cation binding
    		•  2.62077305565026 bayes_pls_golite062009
  • metal ion binding
    		•  2.62077305565026 bayes_pls_golite062009
  • ion binding
    		•  2.61312132078717 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.57032504567157 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.55650624542181 bayes_pls_golite062009
  • tubulin binding
    		•  2.51210014078446 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.37465721152046 bayes_pls_golite062009
  • clathrin binding
    		•  2.36616108128297 bayes_pls_golite062009
  • potassium channel activity
    		•  2.34976925209355 bayes_pls_golite062009
  • microfilament motor activity
    		•  2.31015572544973 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  2.23826952377523 bayes_pls_golite062009
  • protein binding
    		•  2.21291432166051 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  2.19584076943896 bayes_pls_golite062009
  • microtubule binding
    		•  2.17136406283012 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  2.15417471573279 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  2.1474415222764 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  1.99763594451773 bayes_pls_golite062009
  • myosin II heavy chain binding
    		•  1.88775123370459 bayes_pls_golite062009
  • ER retention sequence binding
    		•  1.60111232562018 bayes_pls_golite062009
  • myosin binding
    		•  1.52005099664686 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.51057181410195 bayes_pls_golite062009
  • kinase activity
    		•  1.48008348280256 bayes_pls_golite062009
  • actin-dependent ATPase activity
    		•  1.39855027520112 bayes_pls_golite062009
  • actin filament binding
    		•  1.39015845077273 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.34982153616582 bayes_pls_golite062009
  • myosin heavy chain binding
    		•  1.31753541231868 bayes_pls_golite062009
  • calcium-dependent protein kinase inhibitor activity
    		•  1.29632226581856 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.29595371278065 bayes_pls_golite062009
  • transporter activity
    		•  1.15928534291452 bayes_pls_golite062009
  • cation channel activity
    		•  1.154333064085 bayes_pls_golite062009
  • signal transducer activity
    		•  1.11607939838219 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.11607939838219 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.02715871704923 bayes_pls_golite062009
  • transferase activity
    		•  1.00143834284844 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.993476325956511 bayes_pls_golite062009
  • DNA binding
    		•  0.98588735736701 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.945691505472547 bayes_pls_golite062009
  • phosphatase regulator activity
    		•  0.87149881541475 bayes_pls_golite062009
  • guanylate cyclase regulator activity
    		•  0.84389905735679 bayes_pls_golite062009
  • cyclase regulator activity
    		•  0.84389905735679 bayes_pls_golite062009
  • protein phosphatase regulator activity
    		•  0.822713961141111 bayes_pls_golite062009
  • structural molecule activity
    		•  0.800850121197479 bayes_pls_golite062009
  • calcium channel regulator activity
    		•  0.7164851905066 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.693724160233023 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.666488715029225 bayes_pls_golite062009
  • calcium sensitive guanylate cyclase activator activity
    		•  0.630360514213104 bayes_pls_golite062009
  • gated channel activity
    		•  0.504863425641631 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.386960491413065 bayes_pls_golite062009
  • channel activity
    		•  0.386960491413065 bayes_pls_golite062009
  • hydrolase activity
    		•  0.378268353045111 bayes_pls_golite062009
  • enzyme activator activity
    		•  0.369738999181035 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.362205423422174 bayes_pls_golite062009
    		• 0.34446792626966 bayes_pls_golite062009
  • ion channel activity
    		•  0.343477643719352 bayes_pls_golite062009
  • channel regulator activity
    		•  0.32809521759917 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.246383459363256 bayes_pls_golite062009
  • potassium channel regulator activity
    		•  0.24182293264521 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.116648335890738 bayes_pls_golite062009
  • actin monomer binding
    		•  0.0701886284348601 bayes_pls_golite062009
  • A-type (transient outward) potassium channel activity
    		•  0.010802191005419 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle