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View Structure Prediction Details

Protein: MYO3
Organism: Saccharomyces cerevisiae
Length: 1271 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MYO3.

Description E-value Query
Range		 Subject
Range
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [3..973] [27..987]
MYH4_PIG - Myosin-4 OS=Sus scrofa GN=MYH4 PE=2 SV=1
 0.0 [3..959] [52..1031]
gi|4505301, gi|1... - gi|4505301|ref|NP_002463.1| myosin, heavy polypeptide 8, skeletal muscle, perinatal [Homo sapiens], ...
 0.0 [3..959] [54..1032]
MYH6_MOUSE - Myosin-6 OS=Mus musculus GN=Myh6 PE=1 SV=2
 0.0 [3..959] [51..1031]
MYO11_ARATH - Myosin-11 OS=Arabidopsis thaliana GN=XI-E PE=3 SV=1
 0.0 [3..959] [30..994]
MYH4_RABIT - Myosin-4 OS=Oryctolagus cuniculus GN=MYH4 PE=1 SV=1
 0.0 [3..959] [52..1032]
MYH11_CHICK - Myosin-11 OS=Gallus gallus GN=MYH11 PE=1 SV=4
 0.0 [3..955] [49..1064]

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Predicted Domain #1
Region A:
Residues: [1-641] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVIKKGARR KDVKEPKKRS AKIKKATFDA NKKKEVGISD LTLLSKISDE SINENLKKRF  60
   61 KNGIIYTYIG HVLISVNPFR DLGIYTNAVL ESYKGKNRLE VPPHVFAIAE SMYYNLKSYN 120
  121 ENQCVIISGE SGAGKTEAAK RIMQYIAAAS NSHSESIGKI KDMVLATNPL LESFGCAKTL 180
  181 RNNNSSRHGK YLEIKFNSQF EPCAGNITNY LLEKQRVVGQ IKNERNFHIF YQFTKGASDT 240
  241 YKQMFGVQMP EQYIYTAAAG CTSADQLMRK DYEGTLEAMR TIGLVQEEQD QIFRMLAAIL 300
  301 WIGNISFIEN EEGNAQVGDT SVTDFVAYLL QVDASLLVKC LVERIMQTSH GMKRGSVYHV 360
  361 PLNPVQATAV RDALAKAIYN NLFDWIVDRV NVSLQAFPGA DKSIGILDIY GFEIFEHNSF 420
  421 EQICINYVNE KLQQIFIQLT LKAEQETYER EKIKWTPIKY FDNKVVCDLI EAKNPPGILA 480
  481 AMNDSIATAH ADSNAADQAF AQRLNLFNSN PYFELRANKF VIKHYAGDVT YDINGITDKN 540
  541 KDQLQKDLIE LIGTTTNTFL STIFPDDVDK DSKRRPPTAG DKIIKSANEL VETLSKAEPS 600
  601 YIRTIKPNQT KSPNDYDDHQ VLHQVKYLGL QENVRIRRAG F

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2600.0
Match: 1lkxA_
Description: Myosin S1, motor domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
actin-dependent ATPase activity 5.83616693706338 bayes_pls_golite062009
microfilament motor activity 5.82833334737708 bayes_pls_golite062009
microtubule motor activity 4.51968578934603 bayes_pls_golite062009
motor activity 4.04927796049806 bayes_pls_golite062009
actin binding 3.33639699088484 bayes_pls_golite062009
transporter activity 3.10463051760206 bayes_pls_golite062009
transmembrane transporter activity 2.95886887664984 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.95079405147356 bayes_pls_golite062009
pyrophosphatase activity 2.87427509025394 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.85499564954033 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.85178667290149 bayes_pls_golite062009
tubulin binding 2.67743463093593 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
primary active transmembrane transporter activity 2.61775212528604 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 2.61467977505707 bayes_pls_golite062009
microtubule binding 2.59155206524122 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 2.57552435627908 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 2.57107347424517 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 2.57054427875021 bayes_pls_golite062009
hydrolase activity 2.55157966585974 bayes_pls_golite062009
active transmembrane transporter activity 2.50494515048649 bayes_pls_golite062009
ATPase activity, coupled 2.43862163407966 bayes_pls_golite062009
ADP binding 2.42564874799906 bayes_pls_golite062009
cytoskeletal protein binding 2.4101693596493 bayes_pls_golite062009
ATPase activity 2.39535714892224 bayes_pls_golite062009
actin filament binding 2.24723363507804 bayes_pls_golite062009
myosin light chain binding 2.23966366728473 bayes_pls_golite062009
substrate-specific transporter activity 1.91091452720653 bayes_pls_golite062009
alpha-tubulin binding 1.792591628112 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.56325751172863 bayes_pls_golite062009
signal recognition particle binding 1.51332809264918 bayes_pls_golite062009
plus-end-directed microtubule motor activity 1.38366133153678 bayes_pls_golite062009
protein binding 1.22129154759482 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
ion transmembrane transporter activity 0.977237423302079 bayes_pls_golite062009
structural constituent of muscle 0.960508657568442 bayes_pls_golite062009
purine nucleotide binding 0.929901285538132 bayes_pls_golite062009
nucleotide binding 0.922442819194247 bayes_pls_golite062009
purine ribonucleotide binding 0.920987930180051 bayes_pls_golite062009
ribonucleotide binding 0.920926158369519 bayes_pls_golite062009
GTPase activity 0.83849854735032 bayes_pls_golite062009
nucleic acid binding 0.775560967092349 bayes_pls_golite062009
beta-tubulin binding 0.654735466720932 bayes_pls_golite062009
guanyl nucleotide binding 0.640772201693186 bayes_pls_golite062009
guanyl ribonucleotide binding 0.63468044350616 bayes_pls_golite062009
GTP binding 0.621689261700018 bayes_pls_golite062009
cation transmembrane transporter activity 0.557919489256916 bayes_pls_golite062009
protein transporter activity 0.498432226280822 bayes_pls_golite062009
microtubule-severing ATPase activity 0.491769258942331 bayes_pls_golite062009
DNA binding 0.479412476059825 bayes_pls_golite062009
ATP binding 0.41092997612902 bayes_pls_golite062009
adenyl ribonucleotide binding 0.385813421701492 bayes_pls_golite062009
adenyl nucleotide binding 0.377870145186619 bayes_pls_golite062009
minus-end directed microfilament motor activity 0.329356138573379 bayes_pls_golite062009
plus-end directed microfilament motor activity 0.329356138573379 bayes_pls_golite062009
transcription regulator activity 0.312171320541728 bayes_pls_golite062009
signal transducer activity 0.286367085584159 bayes_pls_golite062009
molecular transducer activity 0.286367085584159 bayes_pls_golite062009
myosin binding 0.274885859454447 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 0.213018989352421 bayes_pls_golite062009
G-protein coupled receptor activity 0.169034229773346 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 0.123304946374679 bayes_pls_golite062009
metal ion transmembrane transporter activity 0.0775601177068852 bayes_pls_golite062009
structural constituent of cytoskeleton 0.0111338193708552 bayes_pls_golite062009
structural constituent of ribosome 0.0102645529518819 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [642-713] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AYRQTFEKFV ERFYLLSPDC SYAGDYTWDG DTLEAVKLIL RDAMIPEKEF QLGVTSVFIK  60
   61 TPESLFALED MR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2600.0
Match: 1lkxA_
Description: Myosin S1, motor domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [714-776] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DKYWYNMAAR IQRAWRRFLQ RRIDAAIKIQ RTIREKKGGN KYVKLRDYGT KLLAGKKERR  60
   61 SMS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.69897
Match: 1wdcA_
Description: SCALLOP MYOSIN REGULATORY DOMAIN
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [777-1097] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLGYRAFMGD YLSCNESKTK GSYIRRQVGI KDKVVFSIKG ECLHSKFGRS AQRLKKVFIL  60
   61 TKKTFYIIGQ TREQNAMKYT QDYKIDVGKI KQVSLTNLQD DWMGVILVNS TQSDPLINTP 120
  121 FKTELMTRLK KLNEKIMIKV GPTIEYHKQP NKLHTVRSKI SDSAPKYGDI YKSSTIYVRR 180
  181 GHPANSKSNK KPKNPGGLSG KPIKSKKSKH KSTHKHTHSH RSHRDAAKKQ PLPSQKPVNP 240
  241 LSLRATAAQA AYNPKPDKTV PIKSSAIPAA KVSSKHSSKP SSKEKVAVKK ASSSHKSSSA 300
  301 KQNQVSMPPS KGVEKNKEPL K

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.522879
Match: 1deqA_
Description: Fibrinogen
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [1098-1189] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ETTATATANI PIPPPPPPMG QPKDPKFEAA YDFPGSGSSS ELPLKKGDIV FISRDEPSGW  60
   61 SLAKLLDGSK EGWVPTAYMT PYKDTRNTVP VA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.154902
Match: 2semA_
Description: Growth factor receptor-bound protein 2 (GRB2), N- and C-terminal domains
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [1190-1271] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ATGAVNDVTN QKSSQIDNTI SSAQEGVQFG SATVGPTSDN QSNPVGTFSD GLASALAARA  60
   61 NKMRAESADD DDNDDGDDDD DW

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle