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Protein Overview: SLD5

General Information:
Name(s) found: SLD5 / YDR489W [SGD]
Description(s) found:
Found 27 descriptions.
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  • Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 294 amino acids

    Gene Ontology:
    Cellular Component: GINS complex [IPILink to PubMed articleLink to PubMed article]
    Biological Process: DNA-dependent DNA replication [IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDINIDDILA ELDKETTAVD STKITQGSSS TTHRDANTIV GSSLDLNDKT QIYVSPQQDF  60
   61 SDLMKSWKNE RCSPELLPYP HQLMKRLLNR ISMQSQLIEN ISMGFLDMQN ASNANPPMPN 120
  121 ESKLPLLCME TELERLKFVI RSYIRCRLSK IDKFSLYLRQ LNEDENSLIS LTDLLSKDEI 180
  181 KYHDTHSLIW LKLVNDSILK YMPEELQAIN DTEGSVNMID EPDWNKFVFI HVNGPPDGKW 240
  241 NEDPLLQENE FGKPCYTVTI PDLKEEVELT IGSIYVMRYE VIRDLLRDDK VALI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) PSF1 PSF2 PSF3 SLD5
    View Details Hazbun TR, et al. (2003) PSF1 PSF2 PSF3 SLD5
    View Details (MIPS) Mewes HW, et al. (2004) PSF1 PSF2 PSF3 SLD5
    View Details Krogan NJ, et al. (2006) CTF4 PSF1 PSF2 PSF3 SLD5
    View Details Qiu et al. (2008) PSF1 PSF2 PSF3 SLD5

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PSF2 No Comments Hazbun TR, et al. (2003)
    View Run PSF2 No Comments Hazbun TR, et al. (2003)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen PSF1 SLD5 2 Uetz P, et al. (2000)
    View Screen PSF1 SLD5 2 Hazbun TR, et al. (2003)
    View Screen PSF2 SLD5 2 Hazbun TR, et al. (2003)
    View Screen PSF2 SLD5 2 Hazbun TR, et al. (2003)
    View Screen SRC1 SLD5 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..27]
    [133..233]    		 Pcons 2.47 Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain; Interferon-induced guanylate-binding protein 1 (GBP1), N-terminal domain
    2 View Details [28..132] Pcons 2.47 Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain; Interferon-induced guanylate-binding protein 1 (GBP1), N-terminal domain
    3 View Details [234..294] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • 3'-5' DNA helicase activity
    		•  3.30007058745861 bayes_pls_golite062009
  • DNA helicase activity
    		•  2.7662250039458 bayes_pls_golite062009
  • binding
    		•  1.86366637427031 bayes_pls_golite062009
  • protein binding
    		•  1.52285169518311 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.2336233528067 bayes_pls_golite062009
  • helicase activity
    		•  1.2110072302388 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.406116199163083 bayes_pls_golite062009
  • transcription elongation regulator activity
    		•  0.37490315580617 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.350000641617868 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.33576520693158 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.333445385039412 bayes_pls_golite062009
  • catalytic activity
    		•  0.161911144249814 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle