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Protein Overview: GAC1

General Information:
Name(s) found: GAC1 / YOR178C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 793 amino acids

    Gene Ontology:
    Cellular Component: protein phosphatase type 1 complex [IDALink to PubMed article]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter [TASLink to PubMed article]
    mitotic cell cycle spindle assembly checkpoint [IMPLink to PubMed article]
    response to heat [IMPLink to PubMed article][IPILink to PubMed article]
    glycogen metabolic process [IPILink to PubMed article]
    meiosis [IPILink to PubMed article]
    Molecular Function: heat shock protein binding [IDALink to PubMed article]
    structural molecule activity [TASLink to PubMed article]
    protein phosphatase type 1 regulator activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVIQTATTLS PAKARPSFPH NDLIKSMSDS LISRPTHPPI RKLKSSLKIS HPEPISRSKS  60
   61 EIFCTSPEKN VRFAIELTTV KRFDKNAEPS SISNENSPTL SPVDSNTAAD DVQLFNNEDC 120
  121 WFNDSSLVTN LLKNEKKFRY MNSLNNMFKL DLYDSEDEDD IDEHINSQAE YGYTYNSLST 180
  181 RGKTSENKSA TSSLATQATN ICDWKLHCTD LVPFKIAPPL FTKTLSASDL QGQLTKYLNG 240
  241 QNVKLHSLTQ LGDDSSKITG LVYVKNLSFE KYLEIKFTFN SWRDIHYVTA NFNRTINSNV 300
  301 DEFKFTIDLN SLKYILLIKR IITMEKNTSS CPLNIELCCR YDVNNETYYD NNNGKNYHLF 360
  361 MTTFKKGGET KEKIPVVVEP ASQTDAAMSP KEMKARFVSS NPTLSRFLPQ SRKFSEDTDY 420
  421 YNTSPLKHLY HNDTTSWVKP KRLNVVLDKL ENATPPPPSS ALANDTARTG KITKDKNNVL 480
  481 APPTASNSID LPILGSQHQS LYSGSSSYSS SSSSISSSLS FASSNNSSTN SSSASCSFPL 540
  541 TELDNFDYAN LYEPNDTFTT ANLFNHSLNS LMPEISTPSF FGGFRNENTI NNNDSKNLVT 600
  601 SLEDSYEDKQ SVITDTTMDE NNKTSTINNS TDTLIKPSKE NGTVKENKSS ANSTSAPSSS 660
  661 QNRASTILND HSNGKSDLKY VNYQSLLDSH CFYNHPSSPN LQSTSFSSAA PFSGISQASD 720
  721 IFDYENEDSD SNQIAGEIDN NSFPPHFYLD EDDKSACLSD DALIDHHRNT NPFINTFSSS 780
  781 PPILSQEVDR WRL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) GAC1 GIP2 GLC7 GLC8 REG1 SDS22
    View Details Ho Y, et al. (2002) EDE1 GAC1 HHF1, HHF2 HTA1 HTA2 HTB1 HTB2 KNS1 MAM33 NOB1 POB3 PSH1 SPT16 SYP1
    View Details Qiu et al. (2008) GAC1 GIP1 GIP2 GLC7 PIG1 REG1 REG2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen GPA1 GAC1 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..171] deduced N/A No confident structure predictions are available.
    2 View Details [172..392] Pfam 9.366532 Putative phosphatase regulatory subunit No confident structure predictions are available.
    3 View Details [393..793] deduced N/A No confident structure predictions are available.
    4 View Details [552..656] deduced N/A No confident structure predictions are available.
    5 View Details [657..793] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle