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Protein Overview: GLC8

General Information:
Name(s) found: GLC8 / YMR311C [SGD]
Description(s) found:
Found 29 descriptions.
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  • Regulatory subunit of protein phosphatase 1 (Glc7p), involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 229 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed articleLink to PubMed article]
    Biological Process: glycogen biosynthetic process [TASLink to PubMed article]
    chromosome segregation [IMPLink to PubMed article]
    Molecular Function: enzyme activator activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGGILKNPLA LSPEQLAQQD PETLEEFRRQ VYENTQKNAK LTSHKRNIPG LDNTKEEGEI  60
   61 IGTSSTFLPK DTLSLKHEQD MLAKMTPEER VQWNQRNLAE NEITKKQFQD IHIDEPKTPY 120
  121 QGAVDPHGEY YRVDDDEDED NSDKKPCQVA NDDIDDLSLG EPEFEIKENK QPDFETNDEN 180
  181 DEDSPEARHK KFEEMRKKHY DVRAIFNKKS REALKDEDED EDDSTTKEP

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) GLC7 GLC8 REG1 SDS22
    View Details (MIPS) Mewes HW, et al. (2004) GAC1 GIP2 GLC7 GLC8 REG1 SDS22
    View Details Krogan NJ, et al. (2006) BNI4 BUD14 GIP3 GLC7 GLC8 HER1 PPZ1 PUF3 SDS22 SOL1 SOL2 YLR257W YPI1
    View Details Ho Y, et al. (2002) ADH4 CFT1 CIC1 CLU1 ERB1 FIN1 FIP1 FPR3 FPR4 GLC7 GLC8 GPH1 GSY1 GSY2 HER1 KEL1 MDH1 MHP1 NOP7 NSA1 PDC5 PHO85 PPZ2 REG1 RRP17 SCD5 SDS22 SEN1 SPB1 SUI2 SUI3 VHS3 YPI1 YTM1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data GLC8 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..88] deduced N/A No confident structure predictions are available.
    2 View Details [89..229] MSA 1.002965 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle