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Protein Overview: AFG2

General Information:
Name(s) found: AFG2 / YLR397C [SGD]
Description(s) found:
Found 28 descriptions.
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  • ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; is essential for pre-60S maturation and release of several preribosome maturation factors; may be involved in degradation of aberrant mRNAs [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 780 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IDALink to PubMed article]
    Biological Process: response to drug [IMPLink to PubMed article]
    Molecular Function: ATPase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAPKSSSSGS KKKSSASSNS ADAKASKFKL PAEFITRPHP SKDHGKETCT AYIHPNVLSS  60
   61 LEINPGSFCT VGKIGENGIL VIARAGDEEV HPVNVITLST TIRSVGNLIL GDRLELKKAQ 120
  121 VQPPYATKVT VGSLQGYNIL ECMEEKVIQK LLDDSGVIMP GMIFQNLKTK AGDESIDVVI 180
  181 TDASDDSLPD VSQLDLNMDD MYGGLDNLFY LSPPFIFRKG STHITFSKET QANRKYNLPE 240
  241 PLSYAAVGGL DKEIESLKSA IEIPLHQPTL FSSFGVSPPR GILLHGPPGT GKTMLLRVVA 300
  301 NTSNAHVLTI NGPSIVSKYL GETEAALRDI FNEARKYQPS IIFIDEIDSI APNRANDDSG 360
  361 EVESRVVATL LTLMDGMGAA GKVVVIAATN RPNSVDPALR RPGRFDQEVE IGIPDVDARF 420
  421 DILTKQFSRM SSDRHVLDSE AIKYIASKTH GYVGADLTAL CRESVMKTIQ RGLGTDANID 480
  481 KFSLKVTLKD VESAMVDIRP SAMREIFLEM PKVYWSDIGG QEELKTKMKE MIQLPLEASE 540
  541 TFARLGISAP KGVLLYGPPG CSKTLTAKAL ATESGINFLA VKGPEIFNKY VGESERAIRE 600
  601 IFRKARSAAP SIIFFDEIDA LSPDRDGSST SAANHVLTSL LNEIDGVEEL KGVVIVAATN 660
  661 RPDEIDAALL RPGRLDRHIY VGPPDVNARL EILKKCTKKF NTEESGVDLH ELADRTEGYS 720
  721 GAEVVLLCQE AGLAAIMEDL DVAKVELRHF EKAFKGIARG ITPEMLSYYE EFALRSGSSS 780
  781

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Gavin AC, et al. (2002) AFG2 TDH3 YAR044W
    View Details Ho Y, et al. (2002) AFG2 ALB1 ARX1 BUD20 DSS4 EHD3 FAA4 FYV4 HHF1, HHF2 HTA1 HTB1 HTB2 LHP1 MAM33 MNP1 MRPS16 NMD3 NOG1 NOP12 NOP13 NOP7 NSA2 NUG1 PRP43 PUF6 PWP1 RIX1 RSM24 RSM25 SEC4 YBL044W YPT1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run BOI1 Sample bob1 (2nd set) from october 2005 McCusker D, et al (2007)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data AFG2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..120] PSI-BLAST 766.9897 Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
    2 View Details [121..241] PSI-BLAST 766.9897 Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
    3 View Details [242..413] PSI-BLAST 766.9897 Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
    4 View Details [414..491] PSI-BLAST 766.9897 Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
    5 View Details [492..667] PSI-BLAST 71.045757 Hexamerization domain of N-ethylmalemide-sensitive fusion (NSF) protein
    6 View Details [668..780] ORFEUS 14.9 AAA domain of cell division protein FtsH


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle