Protein Overview: DSS4

General Information:
Name(s) found:	DSS4 / YPR017C [SGD]
Description(s) found: Found 28 descriptions. SHOW ALL	Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol [SGD]
Organism:	Saccharomyces cerevisiae
Length:	143 amino acids
Gene Ontology:
Cellular Component:	membrane fraction [IDA] soluble fraction [IDA]
Biological Process:	secretory pathway [IGI][IPI]
Molecular Function:	zinc ion binding [IDA] guanyl-nucleotide exchange factor activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKATCSFEG CHSAVITIND DNIINLPEQV HSEFKLLENR TMRDATPSES NFLVVPDVWD  60
   61 FDNVGVSREI PSSILGDLSD KSDFVFEYGN SSWKIKKCLK YLICADCDKG PIGIICKVQD 120
  121 QTKNEERVLH LLSLRSLQIM GRN

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		DSS4 SEC4 YPT1
View Details	Ho Y, et al. (2002)		AFG2 ALB1 ARX1 DSS4 FAA4 GDI1 MRS6 NOG1 NOP7 SEC4 YPT1

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	LSM8	DSS4	2	Uetz P, et al. (2000)
View Screen	PEX1	DSS4	2	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	DSS4	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..143]	deduced	N/A	No confident structure predictions are available.

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
binding	2.12317773040271	bayes_pls_golite062009
transcription regulator activity	1.10086660551766	bayes_pls_golite062009
protein binding	0.741676343474455	bayes_pls_golite062009
nucleic acid binding	0.651182435602198	bayes_pls_golite062009
DNA binding	0.565939042003637	bayes_pls_golite062009
catalytic activity	0.551815283886794	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2