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Protein Overview: PEX1

General Information:
Name(s) found: PEX1 / YKL197C [SGD]
Description(s) found:
Found 26 descriptions.
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  • AAA-peroxin that heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; induced by oleic acid and upregulated during anaerobiosis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1043 amino acids

    Gene Ontology:
    Cellular Component: peroxisome [IDALink to PubMed article]
    Biological Process: peroxisome organization [TAS]
    Molecular Function: ATPase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTTKRLKFE NLRIQFSNAI VGNFLRLPHS IINVLESTNY AIQEFGIAVH SHNSDIPIVH  60
   61 LGWDGHDSGS SENVVLINPV LATVYDLNQK SPLVDLYIQR YDHTHLATEV YVTPETSDDW 120
  121 EIIDANAMRF QNGEILHQTR IVTPGETLIC YLEGIVTKFK IDRVEPSMKS ARITDGSLVV 180
  181 VAPKVNKTRL VKAEYGHSNK TILKNGAIQL LKKVILRSTV CKMDFPKDNL FVVYISDGAQ 240
  241 LPSQKGYASI VKCSLRQSKK SDSDNKSVGI PSKKIGVFIK CDSQIPENHI ALSSHLWDAF 300
  301 FTHPMNGAKI KLEFLQMNQA NIISGRNATV NIKYFGKDVP TKSGDQYSKL LGGSLLTNNL 360
  361 ILPTEQIIIE IKKGESEQQL CNLNEISNES VQWKVTQMGK EEVKDIIERH LPKHYHVKET 420
  421 GEVSRTSKDE DDFITVNSIK KEMVNYLTSP IIATPAIILD GKQGIGKTRL LKELINEVEK 480
  481 DHHIFVKYAD CETLHETSNL DKTQKLIMEW CSFCYWYGPS LIVLDNVEAL FGKPQANDGD 540
  541 PSNNGQWDNA SKLLNFFINQ VTKIFNKDNK RIRVLFSGKQ KTQINPLLFD KHFVSETWSL 600
  601 RAPDKHARAK LLEYFFSKNQ IMKLNRDLQF SDLSLETEGF SPLDLEIFTE KIFYDLQLER 660
  661 DCDNVVTREL FSKSLSAFTP SALRGVKLTK ETNIKWGDIG ALANAKDVLL ETLEWPTKYE 720
  721 PIFVNCPLRL RSGILLYGYP GCGKTLLASA VAQQCGLNFI SVKGPEILNK FIGASEQNIR 780
  781 ELFERAQSVK PCILFFDEFD SIAPKRGHDS TGVTDRVVNQ LLTQMDGAEG LDGVYILAAT 840
  841 SRPDLIDSAL LRPGRLDKSV ICNIPTESER LDILQAIVNS KDKDTGQKKF ALEKNADLKL 900
  901 IAEKTAGFSG ADLQGLCYNA YLKSVHRWLS AADQSEVVPG NDNIEYFSIN EHGRREENRL 960
  961 RLKTLLQQDV VHETKTSTSA ASELTAVVTI NDLLEACQET KPSISTSELV KLRGIYDRFQ1020
 1021 KDRNGEMPNG ENSIDIGSRL SLM

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #34 Asynchronous SPB prep Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen PEX1 DSS4 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PEX1 and PEX3 Huh WK, et al. (2003)
    View Data PEX1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..199] ORFEUS 7.29 N-terminal domain of VAT-N, VAT-Nn; C-terminal domain of VAT-N, VAT-Nc
    2 View Details [200..317] PSI-BLAST 526.457575 Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
    3 View Details [318..414] PSI-BLAST 526.457575 Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
    4 View Details [415..602] PSI-BLAST 526.457575 Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
    5 View Details [603..689] PSI-BLAST 526.457575 Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
    6 View Details [690..821] PSI-BLAST 5.69897 HslU
    7 View Details [822..970] ORFEUS 13.02 Holliday junction helicase RuvB
    8 View Details [971..1043] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.64221234725269 bayes_pls_golite062009
  • SNARE binding
    		•  1.16366125009416 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  1.00212582424428 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.962940053088043 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.944764954837444 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.943619625572574 bayes_pls_golite062009
  • ATPase activity
    		•  0.893914707387449 bayes_pls_golite062009
  • catalytic activity
    		•  0.767627914425245 bayes_pls_golite062009
  • syntaxin binding
    		•  0.67705852056624 bayes_pls_golite062009
  • protein binding
    		•  0.634982583867058 bayes_pls_golite062009
  • hydrolase activity
    		•  0.285603455436646 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle