YRC Public Data Repository - Protein Structure Prediction

Protein:	PEX1
Organism:	Saccharomyces cerevisiae
Length:	1043 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PEX1.

Description	E-value	Query Range	Subject Range
gi\|172098 - gi\|172098\|gb\|AAA34842.1\| ATPase Pas1p [Saccharomyces cerevisiae]	0.0	[1..1043]	[1..1043]
gi\|15920578, gi\|... - gi\|15920578\|ref\|NP_376247.1\| hypothetical protein ST0376 [Sulfolobus tokodaii str. 7], gi\|15621361\|d...	0.0	[187..1023]	[1..746]
TERA_XENLA - Transitional endoplasmic reticulum ATPase OS=Xenopus laevis GN=vcp PE=1 SV=2	0.0	[222..1033]	[8..776]
TERA_RAT - Transitional endoplasmic reticulum ATPase OS=Rattus norvegicus GN=Vcp PE=1 SV=3	0.0	[224..1035]	[10..778]
gi\|168278060 - gi\|168278060\|dbj\|BAG11008.1\| transitional endoplasmic reticulum ATPase [synthetic construct] tr\|G1SR03\|G1SR03... - pep:novel chromosome:oryCun2:1:18809328:18826856:1 gene:ENSOCUG00000006433 transcript:ENSOCUT0000000... VCP - valosin-containing protein TERA_MOUSE - Transitional endoplasmic reticulum ATPase OS=Mus musculus GN=Vcp PE=1 SV=4 gi\|55250201 - gb\|AAH86039.1\| Unknown (protein for MGC:98172) [Xenopus laevis] ENSPTRT00000038666 - null	0.0	[224..1035]	[10..778]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[224..1035]	[10..778]
CDC48_SOYBN - Cell division cycle protein 48 homolog OS=Glycine max GN=CDC48 PE=2 SV=1	0.0	[225..1026]	[16..774]
TER94-PA - The gene TER94 is referred to in FlyBase by the symbol Dmel\TER94 (CG2331, FBgn0261014). It is a pro... gi\|220942716 - gi\|220942716\|gb\|ACL83901.1\| TER94-PA [synthetic construct]	0.0	[224..1042]	[7..786]
TERA_PIG - Transitional endoplasmic reticulum ATPase OS=Sus scrofa GN=VCP PE=1 SV=5	0.0	[224..1035]	[10..778]

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Predicted Domain #1

Region A:
Residues: [1-199]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTTKRLKFE NLRIQFSNAI VGNFLRLPHS IINVLESTNY AIQEFGIAVH SHNSDIPIVH  60
   61 LGWDGHDSGS SENVVLINPV LATVYDLNQK SPLVDLYIQR YDHTHLATEV YVTPETSDDW 120
  121 EIIDANAMRF QNGEILHQTR IVTPGETLIC YLEGIVTKFK IDRVEPSMKS ARITDGSLVV 180
  181 VAPKVNKTRL VKAEYGHSN

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	7.29
Match:	1cz4A
Description:	N-terminal domain of VAT-N, VAT-Nn; C-terminal domain of VAT-N, VAT-Nc
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	1.64221234725269	bayes_pls_golite062009
SNARE binding	1.16366125009416	bayes_pls_golite062009
nucleoside-triphosphatase activity	1.00212582424428	bayes_pls_golite062009
pyrophosphatase activity	0.962940053088043	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.944764954837444	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.943619625572574	bayes_pls_golite062009
ATPase activity	0.893914707387449	bayes_pls_golite062009
catalytic activity	0.767627914425245	bayes_pls_golite062009
syntaxin binding	0.67705852056624	bayes_pls_golite062009
protein binding	0.634982583867058	bayes_pls_golite062009
hydrolase activity	0.285603455436646	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [200-317]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KTILKNGAIQ LLKKVILRST VCKMDFPKDN LFVVYISDGA QLPSQKGYAS IVKCSLRQSK  60
   61 KSDSDNKSVG IPSKKIGVFI KCDSQIPENH IALSSHLWDA FFTHPMNGAK IKLEFLQM

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	526.457575
Match:	1e32A_
Description:	Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [318-414]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NQANIISGRN ATVNIKYFGK DVPTKSGDQY SKLLGGSLLT NNLILPTEQI IIEIKKGESE  60
   61 QQLCNLNEIS NESVQWKVTQ MGKEEVKDII ERHLPKH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	526.457575
Match:	1e32A_
Description:	Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [415-602]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YHVKETGEVS RTSKDEDDFI TVNSIKKEMV NYLTSPIIAT PAIILDGKQG IGKTRLLKEL  60
   61 INEVEKDHHI FVKYADCETL HETSNLDKTQ KLIMEWCSFC YWYGPSLIVL DNVEALFGKP 120
  121 QANDGDPSNN GQWDNASKLL NFFINQVTKI FNKDNKRIRV LFSGKQKTQI NPLLFDKHFV 180
  181 SETWSLRA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	526.457575
Match:	1e32A_
Description:	Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [603-689]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PDKHARAKLL EYFFSKNQIM KLNRDLQFSD LSLETEGFSP LDLEIFTEKI FYDLQLERDC  60
   61 DNVVTRELFS KSLSAFTPSA LRGVKLT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	526.457575
Match:	1e32A_
Description:	Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
Matching Structure (courtesy of the PDB):

Predicted Domain #6

Region A:
Residues: [690-821]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KETNIKWGDI GALANAKDVL LETLEWPTKY EPIFVNCPLR LRSGILLYGY PGCGKTLLAS  60
   61 AVAQQCGLNF ISVKGPEILN KFIGASEQNI RELFERAQSV KPCILFFDEF DSIAPKRGHD 120
  121 STGVTDRVVN QL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	5.69897
Match:	1g4aE_
Description:	HslU
Matching Structure (courtesy of the PDB):

Predicted Domain #7

Region A:
Residues: [822-970]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTQMDGAEGL DGVYILAATS RPDLIDSALL RPGRLDKSVI CNIPTESERL DILQAIVNSK  60
   61 DKDTGQKKFA LEKNADLKLI AEKTAGFSGA DLQGLCYNAY LKSVHRWLSA ADQSEVVPGN 120
  121 DNIEYFSINE HGRREENRLR LKTLLQQDV

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	13.02
Match:	1hqcA
Description:	Holliday junction helicase RuvB
Matching Structure (courtesy of the PDB):

Predicted Domain #8

Region A:
Residues: [971-1043]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VHETKTSTSA ASELTAVVTI NDLLEACQET KPSISTSELV KLRGIYDRFQ KDRNGEMPNG  60
   61 ENSIDIGSRL SLM

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: