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View Structure Prediction Details

Protein: PEX1
Organism: Saccharomyces cerevisiae
Length: 1043 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PEX1.

Description E-value Query
Range
Subject
Range
gi|172098 - gi|172098|gb|AAA34842.1| ATPase Pas1p [Saccharomyces cerevisiae]
0.0 [1..1043] [1..1043]
gi|15920578, gi|... - gi|15920578|ref|NP_376247.1| hypothetical protein ST0376 [Sulfolobus tokodaii str. 7], gi|15621361|d...
0.0 [187..1023] [1..746]
TERA_XENLA - Transitional endoplasmic reticulum ATPase OS=Xenopus laevis GN=vcp PE=1 SV=2
0.0 [222..1033] [8..776]
TERA_RAT - Transitional endoplasmic reticulum ATPase OS=Rattus norvegicus GN=Vcp PE=1 SV=3
0.0 [224..1035] [10..778]
gi|168278060 - gi|168278060|dbj|BAG11008.1| transitional endoplasmic reticulum ATPase [synthetic construct]
tr|G1SR03|G1SR03... - pep:novel chromosome:oryCun2:1:18809328:18826856:1 gene:ENSOCUG00000006433 transcript:ENSOCUT0000000...
VCP - valosin-containing protein
TERA_MOUSE - Transitional endoplasmic reticulum ATPase OS=Mus musculus GN=Vcp PE=1 SV=4
gi|55250201 - gb|AAH86039.1| Unknown (protein for MGC:98172) [Xenopus laevis]
ENSPTRT00000038666 - null
0.0 [224..1035] [10..778]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [224..1035] [10..778]
CDC48_SOYBN - Cell division cycle protein 48 homolog OS=Glycine max GN=CDC48 PE=2 SV=1
0.0 [225..1026] [16..774]
TER94-PA - The gene TER94 is referred to in FlyBase by the symbol Dmel\TER94 (CG2331, FBgn0261014). It is a pro...
gi|220942716 - gi|220942716|gb|ACL83901.1| TER94-PA [synthetic construct]
0.0 [224..1042] [7..786]
TERA_PIG - Transitional endoplasmic reticulum ATPase OS=Sus scrofa GN=VCP PE=1 SV=5
0.0 [224..1035] [10..778]

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Predicted Domain #1
Region A:
Residues: [1-199]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTTKRLKFE NLRIQFSNAI VGNFLRLPHS IINVLESTNY AIQEFGIAVH SHNSDIPIVH  60
   61 LGWDGHDSGS SENVVLINPV LATVYDLNQK SPLVDLYIQR YDHTHLATEV YVTPETSDDW 120
  121 EIIDANAMRF QNGEILHQTR IVTPGETLIC YLEGIVTKFK IDRVEPSMKS ARITDGSLVV 180
  181 VAPKVNKTRL VKAEYGHSN

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.29
Match: 1cz4A
Description: N-terminal domain of VAT-N, VAT-Nn; C-terminal domain of VAT-N, VAT-Nc
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.64221234725269 bayes_pls_golite062009
SNARE binding 1.16366125009416 bayes_pls_golite062009
nucleoside-triphosphatase activity 1.00212582424428 bayes_pls_golite062009
pyrophosphatase activity 0.962940053088043 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.944764954837444 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.943619625572574 bayes_pls_golite062009
ATPase activity 0.893914707387449 bayes_pls_golite062009
catalytic activity 0.767627914425245 bayes_pls_golite062009
syntaxin binding 0.67705852056624 bayes_pls_golite062009
protein binding 0.634982583867058 bayes_pls_golite062009
hydrolase activity 0.285603455436646 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [200-317]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KTILKNGAIQ LLKKVILRST VCKMDFPKDN LFVVYISDGA QLPSQKGYAS IVKCSLRQSK  60
   61 KSDSDNKSVG IPSKKIGVFI KCDSQIPENH IALSSHLWDA FFTHPMNGAK IKLEFLQM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 526.457575
Match: 1e32A_
Description: Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [318-414]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NQANIISGRN ATVNIKYFGK DVPTKSGDQY SKLLGGSLLT NNLILPTEQI IIEIKKGESE  60
   61 QQLCNLNEIS NESVQWKVTQ MGKEEVKDII ERHLPKH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 526.457575
Match: 1e32A_
Description: Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [415-602]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YHVKETGEVS RTSKDEDDFI TVNSIKKEMV NYLTSPIIAT PAIILDGKQG IGKTRLLKEL  60
   61 INEVEKDHHI FVKYADCETL HETSNLDKTQ KLIMEWCSFC YWYGPSLIVL DNVEALFGKP 120
  121 QANDGDPSNN GQWDNASKLL NFFINQVTKI FNKDNKRIRV LFSGKQKTQI NPLLFDKHFV 180
  181 SETWSLRA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 526.457575
Match: 1e32A_
Description: Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [603-689]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PDKHARAKLL EYFFSKNQIM KLNRDLQFSD LSLETEGFSP LDLEIFTEKI FYDLQLERDC  60
   61 DNVVTRELFS KSLSAFTPSA LRGVKLT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 526.457575
Match: 1e32A_
Description: Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [690-821]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KETNIKWGDI GALANAKDVL LETLEWPTKY EPIFVNCPLR LRSGILLYGY PGCGKTLLAS  60
   61 AVAQQCGLNF ISVKGPEILN KFIGASEQNI RELFERAQSV KPCILFFDEF DSIAPKRGHD 120
  121 STGVTDRVVN QL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.69897
Match: 1g4aE_
Description: HslU
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [822-970]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTQMDGAEGL DGVYILAATS RPDLIDSALL RPGRLDKSVI CNIPTESERL DILQAIVNSK  60
   61 DKDTGQKKFA LEKNADLKLI AEKTAGFSGA DLQGLCYNAY LKSVHRWLSA ADQSEVVPGN 120
  121 DNIEYFSINE HGRREENRLR LKTLLQQDV

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 13.02
Match: 1hqcA
Description: Holliday junction helicase RuvB
Matching Structure (courtesy of the PDB):

Predicted Domain #8
Region A:
Residues: [971-1043]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VHETKTSTSA ASELTAVVTI NDLLEACQET KPSISTSELV KLRGIYDRFQ KDRNGEMPNG  60
   61 ENSIDIGSRL SLM

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.561 a.39.1 EF-hand
View Download 0.569 a.101.1 Uteroglobin-like
View Download 0.442 a.8.3 Families 57/38 glycoside transferase middle domain
View Download 0.422 a.37.1 A DNA-binding domain in eukaryotic transcription factors
View Download 0.410 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.388 a.101.1 Uteroglobin-like
View Download 0.385 a.60.9 lambda integrase-like, N-terminal domain
View Download 0.383 a.57.1 Protein HNS-dependent expression A; HdeA
View Download 0.381 a.118.9 ENTH/VHS domain
View Download 0.349 a.51.1 Cytochrome c oxidase subunit h
View Download 0.330 a.16.1 S15/NS1 RNA-binding domain
View Download 0.329 a.60.6 DNA polymerase beta, N-terminal domain-like
View Download 0.329 a.37.1 A DNA-binding domain in eukaryotic transcription factors
View Download 0.327 a.39.1 EF-hand
View Download 0.319 a.101.1 Uteroglobin-like
View Download 0.304 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.297 a.39.1 EF-hand
View Download 0.289 a.39.1 EF-hand
View Download 0.278 a.126.1 Serum albumin-like
View Download 0.259 a.112.1 Description not found.
View Download 0.255 a.118.11 Cytochrome c oxidase subunit E
View Download 0.253 a.60.6 DNA polymerase beta, N-terminal domain-like
View Download 0.237 a.23.5 Hemolysin expression modulating protein HHA
View Download 0.234 a.39.1 EF-hand
View Download 0.233 f.15.1 Small-conductance potassium channel
View Download 0.227 a.2.7 tRNA-binding arm
View Download 0.220 a.8.3 Families 57/38 glycoside transferase middle domain
View Download 0.216 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.216 a.17.1 p8-MTCP1
View Download 0.214 a.79.1 Antitermination factor NusB
View Download 0.210 a.23.5 Hemolysin expression modulating protein HHA
View Download 0.207 a.42.1 MDM2
View Download 0.207 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.206 a.126.1 Serum albumin-like
View Download 0.202 a.58.1 Chemotaxis receptor methyltransferase CheR, N-terminal domain
View Download 0.200 a.60.6 DNA polymerase beta, N-terminal domain-like


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle