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Protein Overview: NUP188

General Information:
Name(s) found: NUP188 / YML103C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Subunit of the nuclear pore complex (NPC), involved in the structural organization of the complex and of the nuclear envelope, also involved in nuclear envelope permeability, interacts with Pom152p and Nic96p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1655 amino acids

    Gene Ontology:
    Cellular Component: nuclear pore [IDALink to PubMed article]
    Biological Process: mRNA export from nucleus [TASLink to PubMed article]
    rRNA export from nucleus [TASLink to PubMed article]
    nuclear pore organization [IMPLink to PubMed article]
    snRNP protein import into nucleus [TASLink to PubMed article]
    mRNA-binding (hnRNP) protein import into nucleus [TASLink to PubMed article]
    snRNA export from nucleus [TASLink to PubMed article]
    tRNA export from nucleus [TASLink to PubMed article]
    NLS-bearing substrate import into nucleus [TASLink to PubMed article]
    protein export from nucleus [TASLink to PubMed article]
    ribosomal protein import into nucleus [TASLink to PubMed article]
    Molecular Function: structural molecule activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATPSFGNSS PQLTFTHVAN FMNDAAADVS AVDAKQLAQI RQFLKANKTN LIESLNTIRQ  60
   61 NVTSSGDHNK LRSTIANLLQ INVDNDPFFA QSEDLSHAVE FFMSERSSRL HIVYSLLVNP 120
  121 DIDLETYSFI DNDRFNVVGK LISIISSVIQ NYDIITASSL AHDYNNDQDM FTIVSLVQLK 180
  181 KFSDLKFILQ ILQILNLMIL NTKVPVDIVN QWFLQYQNQF VEFCRNINST DKSIDTSSLQ 240
  241 LYKFQNFQDL SYLSETLISR ISSLFTITTI LILGLNTSIA QFDIQSPLYM DTETFDTVNS 300
  301 ALENDVATNI VNEDPIFHPM IHYSWSFILY YRRALQSSES FDDSDITKFA LFAESHDVLQ 360
  361 KLNTLSEILS FDPVYTTVIT VFLEFSLNFI PITASTSRVF AKIISKAPEQ FIENFLTNDT 420
  421 FEKKLSIIKA KLPLLNESLI PLINLALIDT EFANFELKDI CSFAVTKSSL NDLDYDLIAD 480
  481 TITNSSSSSD IIVPDLIELK SDLLVAPPLE NENSNCLLSI PKSTKGKILT IKQQQQQQQQ 540
  541 QNGQQPPTTS NLIIFLYKFN GWSLVGRILQ NLLHSYMEKG TQLDDLQHEL MISIIKLVTN 600
  601 VVDPKTSIEK SSEILSYLSN SLDTSASTIN GASIIQVIFE IFEISLQRKD YTSIVQCCEF 660
  661 MTMLTPNYLH LVSSYLNKSD LLDKYGKTGL SNMILGSVEL STGDYTFTIQ LLKLTKVFIR 720
  721 ESLSLKNIHI SKRSKIDIIN KLILHAIHIF ESYYNWKYNN FLQKFEIAFH LTLIFYDVLH 780
  781 DVFTINPHQK DQLIISSSAN KLLQLFLTPM DSIDLAPNTL TNILISPLNT TTKILGDKIL 840
  841 GNLYSKVMNN SFKLCTLLIA IRGSNRDLKP SNLEKLLFIN SSKLVDVYTL PSYVHFKVQI 900
  901 IELLSYLVEA PWNDDYPFLL SFLGEAKSMA FLKEVLSDLS SPVQDWNLLR SLYIFFTTLL 960
  961 ESKQDGLSIL FLTGQFASNK KINDESSIDK KSSILTVLQK NSLLLDSTPE EVSCKLLETI1020
 1021 TYVLNTWTNS KIFIKDPKFV NSLLAKLKDS KKLFQKKENL TRDETVSLIK KYKLISRIVE1080
 1081 IFALCIYNST DSNSEILNFL NQEDLFELVH HFFQIDGFNK TFHDELNLKF KEKWPSLELQ1140
 1141 SFQKIPLSRI NENENFGYDI PLLDIVLKAD RSWNEPSKSQ TNFKEEITDA SLNLQYVNYE1200
 1201 ISTAKAWGAL ITTFVKRSTV PLNDGFVDLV EHFLKLNIDF GSDKQMFTQI YLERIELSFY1260
 1261 ILYSFKLSGK LLKEEKIIEL MNKIFTIFKS GEIDFIKNIG KSLKNNFYRP LLRSVLVLLE1320
 1321 LVSSGDRFIE LISDQLLEFF ELVFSKGVYL ILSEILCQIN KCSTRGLSTD HTTQIVNLED1380
 1381 NTQDLLLLLS LFKKITNVNP SKNFNVILAS SLNEVGTLKV ILNLYSSAHL IRINDEPILG1440
 1441 QITLTFISEL CSIEPIAAKL INSGLYSVLL ESPLSVAIQQ GDIKPEFSPR LHNIWSNGLL1500
 1501 SIVLLLLSQF GIKVLPETCL FVSYFGKQIK STIYNWGDNK LAVSSSLIKE TNQLVLLQKM1560
 1561 LNLLNYQELF IQPKNSDDQQ EAVELVIGLD SEHDKKRLSA ALSKFLTHPK YLNSRIIPTT1620
 1621 LEEQQQLEDE SSRLEFVKGI SRDIKALQDS LFKDV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) GLE2 NOP14 NUP1 NUP100 NUP116 NUP133 NUP157 NUP159 NUP170 NUP188 NUP2 NUP42 POM152
    View Details Krogan NJ, et al. (2006) ABF2 ARG82 CKI1 CMR1 HHF1, HHF2 HTA1 HTA2 HTB1 HTB2 NUP188 PPH3 PSY2 PSY4 RRD1 SLX5 SLX8 SPT5 STP1 TOP2
    View Details Qiu et al. (2008) ASM4 DBP5 GLE2 KAP120 MEX67 NDC1 NIC96 NSP1 NUP1 NUP100 NUP116 NUP120 NUP133 NUP145 NUP157 NUP159 NUP170 NUP188 NUP192 NUP2 NUP42 NUP49 NUP53 NUP57 NUP60 NUP82 NUP84 NUP85 POM152 SEH1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run SLI15 No Comments Cheeseman IM, et al. (2002)
    View Run SWC4 No Comments Hazbun TR, et al. (2003)
    View Run CAB5 No Comments Hazbun TR, et al. (2003)
    View Run IPI3 No Comments Hazbun TR, et al. (2003)
    View Run GPI14 No Comments Hazbun TR, et al. (2003)
    View Run KIP3 No Comments Cheeseman IM, et al. (2002)
    View Run YMR185W No Comments Hazbun TR, et al. (2003)
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample bob1 (2nd set) from october 2005 McCusker D, et al (2007)
    View Run MLP2 #34 Asynchronous SPB prep Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data NUP188 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..1655] deduced N/A No confident structure predictions are available.
    2 View Details [183..406] deduced N/A No confident structure predictions are available.
    3 View Details [407..513] deduced N/A No confident structure predictions are available.
    4 View Details [514..603] deduced N/A No confident structure predictions are available.
    5 View Details [604..786] deduced N/A No confident structure predictions are available.
    6 View Details [787..864] deduced N/A No confident structure predictions are available.
    7 View Details [865..1050] deduced N/A No confident structure predictions are available.
    8 View Details [1051..1175] deduced N/A No confident structure predictions are available.
    9 View Details [1176..1378] deduced N/A No confident structure predictions are available.
    10 View Details [1379..1655] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.54

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle