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Protein Overview: GLE2

General Information:
Name(s) found: GLE2 / YER107C [SGD]
Description(s) found:
Found 29 descriptions.
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  • Component of the Nup82 subcomplex of the nuclear pore complex; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 365 amino acids

    Gene Ontology:
    Cellular Component: nuclear pore [IDALink to PubMed article]
    Biological Process: mRNA export from nucleus [IMPLink to PubMed article]
    rRNA export from nucleus [TASLink to PubMed article]
    nuclear envelope organization [IMPLink to PubMed article]
    nuclear pore organization [IMPLink to PubMed article]
    snRNP protein import into nucleus [TASLink to PubMed article]
    mRNA-binding (hnRNP) protein import into nucleus [TASLink to PubMed article]
    snRNA export from nucleus [TASLink to PubMed article]
    protein import into nucleus [IMPLink to PubMed article]
    tRNA export from nucleus [TASLink to PubMed article]
    NLS-bearing substrate import into nucleus [TASLink to PubMed article]
    protein export from nucleus [TASLink to PubMed article]
    ribosomal protein import into nucleus [TASLink to PubMed article]
    Molecular Function: structural molecule activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFFNRSNTT SALGTSTAMA NEKDLANDIV INSPAEDSIS DIAFSPQQDF MFSASSWDGK  60
   61 VRIWDVQNGV PQGRAQHESS SPVLCTRWSN DGTKVASGGC DNALKLYDIA SGQTQQIGMH 120
  121 SAPIKVLRFV QCGPSNTECI VTGSWDKTIK YWDMRQPQPV STVMMPERVY SMDNKQSLLV 180
  181 VATAERHIAI INLANPTTIF KATTSPLKWQ TRCVACYNEA DGYAIGSVEG RCSIRYIDDG 240
  241 MQKKSGFSFK CHRQTNPNRA PGSNGQSLVY PVNSIAFHPL YGTFVTAGGD GTFNFWDKNQ 300
  301 RHRLKGYPTL QASIPVCSFN RNGSVFAYAL SYDWHQGHMG NRPDYPNVIR LHATTDEEVK 360
  361 EKKKR

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) GLE2 NOP14 NUP1 NUP100 NUP116 NUP133 NUP157 NUP159 NUP170 NUP188 NUP2 NUP42 POM152
    View Details Krogan NJ, et al. (2006) ALB1 ARX1 DBP9 GLE2 PSE1 RAD27 SLX9 THO1
    View Details Gavin AC, et al. (2002) GLE2 PRO1
    View Details Qiu et al. (2008) ASM4 GLE2 NDC1 NIC96 NSP1 NUP1 NUP100 NUP116 NUP133 NUP145 NUP157 NUP159 NUP170 NUP188 NUP2 NUP42 NUP49 NUP53 NUP57 NUP82 NUP84 NUP85 POM152 SEC13 SUS1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data GLE2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..365] PSI-BLAST 125.156545 Tup1, C-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • snoRNA binding
    		•  3.44364487903281 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  3.1056443224755 bayes_pls_golite062009
  • binding
    		•  2.42570478946173 bayes_pls_golite062009
    		• 2.40807791198019 bayes_pls_golite062009
  • actin binding
    		•  2.27900251096697 bayes_pls_golite062009
  • tubulin binding
    		•  2.01759734664395 bayes_pls_golite062009
  • microtubule binding
    		•  1.98090681825586 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.95667720244696 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.90457914882449 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.6725482369574 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  1.59258100795958 bayes_pls_golite062009
  • RNA binding
    		•  1.50295916950465 bayes_pls_golite062009
  • structural molecule activity
    		•  1.47448876401574 bayes_pls_golite062009
  • DNA binding
    		•  1.38475369554616 bayes_pls_golite062009
  • dynactin binding
    		•  1.29574819250251 bayes_pls_golite062009
  • protein binding
    		•  1.21879977456466 bayes_pls_golite062009
  • transporter activity
    		•  1.21549336905926 bayes_pls_golite062009
  • protein transporter activity
    		•  0.964340340346761 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.963909191437161 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.937944931047515 bayes_pls_golite062009
  • dynein binding
    		•  0.92848877230786 bayes_pls_golite062009
  • transcription factor activity
    		•  0.804334981068351 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.734793983890004 bayes_pls_golite062009
  • signal transducer activity
    		•  0.577438981735303 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.577438981735303 bayes_pls_golite062009
  • actin filament binding
    		•  0.554537899540618 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  0.535041400676017 bayes_pls_golite062009
  • transcription factor binding
    		•  0.412844855996155 bayes_pls_golite062009
  • receptor activity
    		•  0.322599767074871 bayes_pls_golite062009
  • ligase activity
    		•  0.20682813699621 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.19391619547146 bayes_pls_golite062009
  • hydrolase activity
    		•  0.181211933860468 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.168317261786777 bayes_pls_golite062009
  • histone binding
    		•  0.166694897714113 bayes_pls_golite062009
  • kinase activity
    		•  0.127621956173205 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.118975415284669 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.00585398682921312 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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