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Protein Overview: NUP145

General Information:
Name(s) found: NUP145 / YGL092W [SGD]
Description(s) found:
Found 27 descriptions.
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  • Essential nucleoporin, catalyzes its own cleavage in vivo to generate a C-terminal fragment that assembles into the Nup84p subcomplex of the nuclear pore complex, and an N-terminal fragment of unknown function that is homologous to Nup100p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1317 amino acids

    Gene Ontology:
    Cellular Component: nuclear pore [IDALink to PubMed article]
    Biological Process: tRNA splicing, via endonucleolytic cleavage and ligation [IMPLink to PubMed article]
    protein export from nucleus [TASLink to PubMed article]
    ribosomal protein import into nucleus [TASLink to PubMed article]
    mRNA export from nucleus [IMPLink to PubMed article]
    rRNA export from nucleus [TASLink to PubMed article]
    nuclear pore organization [IMPLink to PubMed article]
    snRNP protein import into nucleus [TASLink to PubMed article]
    mRNA-binding (hnRNP) protein import into nucleus [TASLink to PubMed article]
    snRNA export from nucleus [TASLink to PubMed article]
    protein import into nucleus [IMPLink to PubMed article]
    chromosome localization [IMPLink to PubMed article]
    tRNA export from nucleus [TASLink to PubMed article]
    NLS-bearing substrate import into nucleus [TASLink to PubMed article]
    Molecular Function: RNA binding [IDALink to PubMed article]
    structural molecule activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFNKSVNSGF TFGNQNTSTP TSTPAQPSSS LQFPQKSTGL FGNVNVNANT STPSPSGGLF  60
   61 NANSNANSIS QQPANNSLFG NKPAQPSGGL FGATNNTTSK SAGSLFGNNN ATANSTGSTG 120
  121 LFSGSNNIAS STQNGGLFGN SNNNNITSTT QNGGLFGKPT TTPAGAGGLF GNSSSTNSTT 180
  181 GLFGSNNTQS STGIFGQKPG ASTTGGLFGN NGASFPRSGE TTGTMSTNPY GINISNVPMA 240
  241 VADMPRSITS SLSDVNGKSD AEPKPIENRR TYSFSSSVSG NAPLPLASQS SLVSRLSTRL 300
  301 KATQKSTSPN EIFSPSYSKP WLNGAGSAPL VDDFFSSKMT SLAPNENSIF PQNGFNFLSS 360
  361 QRADLTELRK LKIDSNRSAA KKLKLLSGTP AITKKHMQDE QDSSENEPIA NADSVTNIDR 420
  421 KENRDNNLDN TYLNGKEQSN NLNKQDGENT LQHEKSSSFG YWCSPSPEQL ERLSLKQLAA 480
  481 VSNFVIGRRG YGCITFQHDV DLTAFTKSFR EELFGKIVIF RSSKTVEVYP DEATKPMIGH 540
  541 GLNVPAIITL ENVYPVDKKT KKPMKDTTKF AEFQVFDRKL RSMREMNYIS YNPFGGTWTF 600
  601 KVNHFSIWGL VNEEDAEIDE DDLSKQEDGG EQPLRKVRTL AQSKPSDKEV ILKTDGTFGT 660
  661 LSGKDDSIVE EKAYEPDLSD ADFEGIEASP KLDVSKDWVE QLILAGSSLR SVFATSKEFD 720
  721 GPCQNEIDLL FSECNDEIDN AKLIMKERRF TASYTFAKFS TGSMLLTKDI VGKSGVSIKR 780
  781 LPTELQRKFL FDDVYLDKEI EKVTIEARKS NPYPQISESS LLFKDALDYM EKTSSDYNLW 840
  841 KLSSILFDPV SYPYKTDNDQ VKMALLKKER HCRLTSWIVS QIGPEIEEKI RNSSNEIEQI 900
  901 FLYLLLNDVV RASKLAIESK NGHLSVLISY LGSNDPRIRD LAELQLQKWS TGGCSIDKNI 960
  961 SKIYKLLSGS PFEGLFSLKE LESEFSWLCL LNLTLCYGQI DEYSLESLVQ SHLDKFSLPY1020
 1021 DDPIGVIFQL YAANENTEKL YKEVRQRTNA LDVQFCWYLI QTLRFNGTRV FSKETSDEAT1080
 1081 FAFAAQLEFA QLHGHSLFVS CFLNDDKAAE DTIKRLVMRE ITLLRASTND HILNRLKIPS1140
 1141 QLIFNAQALK DRYEGNYLSE VQNLLLGSSY DLAEMAIVTS LGPRLLLSNN PVQNNELKTL1200
 1201 REILNEFPDS ERDKWSVSIN VFEVYLKLVL DNVETQETID SLISGMKIFY DQYKHCREVA1260
 1261 ACCNVMSQEI VSKILEKNNP SIGDSKAKLL ELPLGQPEKA YLRGEFAQDL MKCTYKI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) NUP120 NUP145 NUP84 NUP85 SEC13 SEH1
    View Details (MIPS) Mewes HW, et al. (2004) NUP120 NUP145 NUP84 NUP85 SEC13 SEH1
    View Details Krogan NJ, et al. (2006) MEX67 NUP120 NUP145 NUP84 NUP85 SEH1
    View Details Gavin AC, et al. (2006) NUP120 NUP145 NUP84 NUP85 SEC13 SEH1
    View Details Gavin AC, et al. (2002) CKA1 CKA2 CKB1 DBP2 MRPS28 NUP120 NUP145 NUP84 NUP85 RPP2B SEC13 SEC16 SEC23 SEC31 SEH1 STM1
    View Details Ho Y, et al. (2002) ADE13 NUP145 NUP84 NUP85 SEC13 SEH1
    View Details Qiu et al. (2008) ASM4 GLE2 KAP123 MEX67 NDC1 NIC96 NSP1 NUP1 NUP100 NUP116 NUP120 NUP133 NUP145 NUP157 NUP159 NUP170 NUP188 NUP192 NUP2 NUP42 NUP49 NUP53 NUP57 NUP82 NUP84 NUP85 POM152 SEC13 SEH1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run SLI15 No Comments Cheeseman IM, et al. (2002)
    View Run TAM41 No Comments Hazbun TR, et al. (2003)
    View Run SPP382 No Comments Hazbun TR, et al. (2003)
    View Run NOP9 No Comments Hazbun TR, et al. (2003)
    View Run NSE5 No Comments Hazbun TR, et al. (2003)
    View Run ASF1 3829 - low filter Green EM, et al (2005)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data NUP145 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..156] PSI-BLAST 5.69897 Fibrinogen
    2 View Details [157..390] MSA 19.626995 View MSA. No confident structure predictions are available.
    3 View Details [391..1049] deduced N/A No confident structure predictions are available.
    4 View Details [1050..1234] MSA 2.012935 View MSA. No confident structure predictions are available.
    5 View Details [1235..1317] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle