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Protein Overview: NUP170

General Information:
Name(s) found: NUP170 / YBL079W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Subunit of the nuclear pore complex (NPC), required for NPC localization of specific nucleoporins; involved in nuclear envelope permeability and chromosome segregation; has similar to Nup157p; essential role, with Nup157p, in NPC assembly [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1502 amino acids

    Gene Ontology:
    Cellular Component: nuclear pore [IDALink to PubMed article]
    Biological Process: mRNA export from nucleus [TASLink to PubMed article]
    rRNA export from nucleus [TASLink to PubMed article]
    nuclear pore organization [TASLink to PubMed article]
    snRNP protein import into nucleus [TASLink to PubMed article]
    mRNA-binding (hnRNP) protein import into nucleus [TASLink to PubMed article]
    snRNA export from nucleus [TASLink to PubMed article]
    tRNA export from nucleus [TASLink to PubMed article]
    NLS-bearing substrate import into nucleus [TASLink to PubMed article]
    chromosome segregation [IMPLink to PubMed article]
    protein export from nucleus [TASLink to PubMed article]
    protein import into nucleus, docking [IPILink to PubMed article]
    ribosomal protein import into nucleus [TASLink to PubMed article]
    Molecular Function: structural molecule activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFQSFFHNNG PAAAGETFSD SRSYPLTNHQ EVPRNGLNEL ASSATKAQQQ PTHILNSYPI  60
   61 TGSNPLMRAS AMGATSGSIN PNMSNMNEHI RVSGMGTSKP LDLAGKYIDH LQHKDSNTPV 120
  121 LDERSYYNSG VDYNFSREKN GLGAFTPFEK QDVFNIPDEI LHEFSTSQTK TDMGIFPELN 180
  181 RCWITIDNKL ILWNINNDNE YQVVDDMKHT IQKVALVRPK PNTFVPAVKH LLLISTTMEL 240
  241 FMFAISLDKA TNELSVFNTH LSVPVQGIDV IDIVSHERSG RIFFAGQASG LNIWELHYSG 300
  301 SDDWFNSKCS KVCLTKSALL SLLPTNMLSQ IPGVDFIQAL FEDNSNGNGG FSQETITQLT 360
  361 IDQQRGIIYS LSSKSTIRAY VITEKSLEGP MSIEPAYISR IIGTTTARAA PILGPKYLKI 420
  421 VKISSVAPEE NNNLFLVALT VGGVRLYFNG SMGRFNIEAL RLESIKFPPS SVTPEVIQQE 480
  481 LLHQQQEQAK RSFPFFSNLM SSEPVLLKFQ KKSSVLLETT KASTIISPGI FFSAVIKSSQ 540
  541 QTHQQEKKEN SSVTGTTATA GSKTVKQQPV TLQHKLFVSV PDYGILKTHG KYVENATFLE 600
  601 TAGPVQQIIP LSGLFNATTK PQGFANEFAT QYTSETLRVA VLTSTSIEIY KYRTPDEIFE 660
  661 DLIDNPLPFV LNYGAAEACS TALFVTCKSN KSEKLRSNAL TFLTMGIPGV VDIKPVYNRY 720
  721 SVSTVSSLLS KPTLSTATTN LQQSITGFSK PSPANKEDFD LDDVILSPRF YGIALLITRL 780
  781 LRDIWGRHVF MTFTDNRVTS HAFISSSDPI TPSINNLKSD EISQNRNIIS KVSISKDCIE 840
  841 YYLSSINILN EFFITYGDSI SQISAPYVLA NNSNGRVIDK TEEVANQAES IAINAMIKMV 900
  901 QSIKEGLSFL NVLYEESEVE GFDNQYLGFK DIISFVSLDV QKDLVKLDFK DLFAPNDKTK 960
  961 SLIREILLSI INRNITKGAS IEYTATALQE RCGSFCSASD ILGFRAIEHL RRAKEIGLRN1020
 1021 YDSLNYHLKN ATALLEQIVD DLSIEKLKEA VSMMLSVNYY PKSIEFLLNI ANSMDKGKLA1080
 1081 CQYVANGFLE NDDRKQYYDK RILVYDLVFD TLIKVDELAE KKQSSKTQNQ ISISNDDEVK1140
 1141 LRQKSYEAAL KYNDRLFHYH MYDWLVSQNR EEKLLDIETP FILPYLMEKA GSSLKISNIL1200
 1201 WVYYSRRSKF FESAEILYRL ATSNFDITLF ERIEFLSRAN GFCNSVSPLS QKQRIVQLAS1260
 1261 RIQDACEVAG IQGDILSLVY TDARIDSAIK DELIKTLDGK ILSTSELFND FAVPLSYHEI1320
 1321 ALFIFKIADF RDHEVIMAKW DELFQSLRME FNNTGKKEDS MNFINLLSNV LIKIGKNVQD1380
 1381 SEFIFPIFEL FPIVCNFFYE TLPKEHIVSG SIVSIFITAG VSFNKMYYIL KELIETSDSD1440
 1441 NSVFNKEMTW LIHEWYKSDR KFRDIISYND IIHLKEYKID NDPIEKYVKN SGNNLGICFY1500
 1501 KE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) GLE2 NOP14 NUP1 NUP100 NUP116 NUP133 NUP157 NUP159 NUP170 NUP188 NUP2 NUP42 POM152
    View Details Krogan NJ, et al. (2006) ACB1 ADE13 BI2 FRE7 KNS1 NUP170 STE2
    View Details Qiu et al. (2008) ASM4 GLE2 KAP120 NDC1 NIC96 NSP1 NUP1 NUP100 NUP116 NUP120 NUP133 NUP145 NUP157 NUP159 NUP170 NUP188 NUP192 NUP2 NUP42 NUP49 NUP53 NUP57 NUP60 NUP82 NUP85 POM152 SEC13 SUS1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data NUP170 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..75] deduced N/A No confident structure predictions are available.
    2 View Details [76..1502] Pfam 1000.0 Non-repetitive/WGA-negative nucleoporin No confident structure predictions are available.
    3 View Details [477..712] deduced N/A No confident structure predictions are available.
    4 View Details [713..871] deduced N/A No confident structure predictions are available.
    5 View Details [872..954] deduced N/A No confident structure predictions are available.
    6 View Details [955..1016] MSA 1.037995 View MSA. No confident structure predictions are available.
    7 View Details [1017..1152] MSA 1.039976 View MSA. No confident structure predictions are available.
    8 View Details [1153..1349] deduced N/A No confident structure predictions are available.
    9 View Details [1350..1502] MSA 2.037993 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  2.23598589443994 bayes_pls_golite062009
  • protein binding
    		•  1.35242477415251 bayes_pls_golite062009
    		• 1.27327168246392 bayes_pls_golite062009
  • transporter activity
    		•  1.23232041140488 bayes_pls_golite062009
  • snoRNA binding
    		•  1.22563757604746 bayes_pls_golite062009
  • protein transporter activity
    		•  0.946697045757834 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.750051725890322 bayes_pls_golite062009
  • RNA binding
    		•  0.658451712028574 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.442203655186701 bayes_pls_golite062009
  • structural molecule activity
    		•  0.281751211382124 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.271959658140432 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0245411309982146 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.76

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle