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Protein Overview: NUP192

General Information:
Name(s) found: NUP192 / YJL039C [SGD]
Description(s) found:
Found 25 descriptions.
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  • Essential structural subunit of the nuclear pore complex (NPC), localizes to the nuclear periphery of nuclear pores, homologous to human p205 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1683 amino acids

    Gene Ontology:
    Cellular Component: nuclear pore [TASLink to PubMed article]
    Biological Process: nuclear pore organization [IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: structural constituent of nuclear pore [IMPLink to PubMed article][IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKWSAIPFQT LYRSIESGEF DFDLFKEVLP DLQNLNLNTD KLKNNASRSQ LEKGEIELSD  60
   61 GSTFKVNQEF IFEAISLSDE LNLDEIVACE LILSGDTTAN NGKVQYFLRR QYILQIVSFI 120
  121 VNCFHEDTEL YQELIKNGAL VSNILSAFKF IHTQLSEIKQ QINKAQILEN YNALFQQNIK 180
  181 FRRDFLLREY DILSQILYGL VDKGAIMKNK DFILSLLHHV SELDSNDFFI IYYTPAFFHL 240
  241 FASLRVLPDA DVKLLHSQFM KDLKDDSIYT KPVKVALIFI FFAYFIGWCK EDPKRRADTM 300
  301 DFKTDVDEPM TSAVELGAIE QILIFAADTS IVEQDKSMEL FYDIRSLLER HIPRLIPKQL 360
  361 LDDEKIFSQT TNSTYNPASA TDNMSGRGLW NPSYPGMMST TGTARLNSMP NNVNEYSYTT 420
  421 IVLSDQTQEF FLSSFDDVLQ TIITDCAFLL TKIKDAEEDS LLSGEDLTLD DISLKADLER 480
  481 FFLSIYFFYA SRPEYSCTFW SDKESNAYGF IEWCSRCNDN LMRSCFYLMV SSLSFGPENA 540
  541 LNVYHYFGEN SSISWKNIAQ CLSDYTKKIS NFNSSLHKRQ QFSESTHNDI DSTAVALEEG 600
  601 LNEEAVIFLS SLLTLVGSVT YQVDEDVKSS LSKVFSDVLF EFTKINTPLV GAAFKVISNL 660
  661 VPKLESSRTK FWSFLDSLIF KDSSLNYSSE SYRNAFTNVL TKYSDVLGFL QLFHNLISIH 720
  721 SRENNSEYMV FGKLAFPTRL GQGYRKVGIW PYFDYIFNDI LAHVDQIVDI RNKRAVQLPI 780
  781 LKIIYTGLCS FDYSVILNSI PAAANLDALV DCENFFNYVQ ECPAIPIFNY IFTEKIYKSI 840
  841 FNVVDVGVDQ LSIELEGGKN QAELLQLAVK IINKVLDYQE TYVEELFPIV KKHGKTDYFL 900
  901 PKNYSLHGLR SFYDAIFFNI PLVAHLGLYV GVDDQILATN SLRILAKLSE RSNGSVASLS 960
  961 KRNKLLTIFD SVDESARIKD AFITQLESSI TDAGVLALKL ELLDFLTSNL SNYSRTMTIS1020
 1021 HLLLGFQVSN VISLGPNLAT FISSGTSLLD SLISVLEASL NSITKDNIDY APMRLATAAL1080
 1081 EIILKLCRNP LTSGLLYSYL IKENFFERIM ILDPQVTRFT TWNGSPFDNS TEEKCKNFIE1140
 1141 SESVGAFLSF LAYRNYWTQY LGLFIHKISF SGTKSEVLTY VNYLISNTMY SVRLFSFLDP1200
 1201 LNYGNICEPK ETLSIFTNVP LNLEQVTLNK YCSGNIYDFH KMENLMRLIK RVRAESLHSN1260
 1261 SFSLTVSKEQ FLKDADVECI KAKSHFTNII SRNKALELNL SVLHSWVQLV QIIVTDGKLE1320
 1321 PSTRSNFILE VFGTIIPKIS DYIEFNITFS EELVSLAVFL FDIYNRDRKL ITDKGTVDGR1380
 1381 LYQLFKTCIQ GINSPLSSVA LRSDFYILAN HYLSRVLSDQ VGSEKVLQDL RLGSKKLVEI1440
 1441 IWNDVVYGEG TSRVTGILLL DSLIQLANRS KENFILDSLM KTTRLLLIIR SLKNTDALLN1500
 1501 STTEHINIDD LLYELTAFKA TVFFLIRVAE TRGGASALIE NNLFRIIAEL SFLKVDPDLG1560
 1561 LDLMFDEVYV QNSKFLKVNV TLDNPLLVDK DANGVSLFEL IVPIFQLISA VLVSMGSSNK1620
 1621 AVVQTVKGLL NTYKRLVIGI FKRDLLREKE DKKNSSDPNN QSLNEMVKLI VMLCTLTGYQ1680
 1681 NND

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Gavin AC, et al. (2006) GDB1 NUP192
    View Details Qiu et al. (2008) KAP120 NSP1 NUP1 NUP100 NUP133 NUP145 NUP157 NUP159 NUP170 NUP188 NUP192 NUP53 NUP82

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run YJR012C No Comments Hazbun TR, et al. (2003)
    View Run CLB2 No Comments McCusker D, et al (2007)
    View Run YPI1 No Comments Hazbun TR, et al. (2003)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data NUP192 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..686] deduced N/A No confident structure predictions are available.
    2 View Details [687..1204] MSA 1.009913 View MSA. No confident structure predictions are available.
    3 View Details [1205..1683] deduced N/A No confident structure predictions are available.
    4 View Details [564..684] deduced N/A No confident structure predictions are available.
    5 View Details [685..852] MSA 1.051994 View MSA. No confident structure predictions are available.
    6 View Details [853..961] deduced N/A No confident structure predictions are available.
    7 View Details [962..1153] MSA 1.051971 View MSA. No confident structure predictions are available.
    8 View Details [1154..1340] deduced N/A No confident structure predictions are available.
    9 View Details [1341..1449] deduced N/A No confident structure predictions are available.
    10 View Details [1450..1571] MSA 2.033961 View MSA. No confident structure predictions are available.
    11 View Details [1572..1683] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.83

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle