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Protein Overview: RNR3

General Information:
Name(s) found: RNR3 / YIL066C [SGD]
Description(s) found:
Found 22 descriptions.
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  • One of two large regulatory subunits of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 869 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    ribonucleoside-diphosphate reductase complex [TASLink to PubMed article]
    Biological Process: DNA replication [TASLink to PubMed article]
    Molecular Function: ribonucleoside-diphosphate reductase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYVIKRDGRK EPVQFDKITS RITRLSYGLD PNRIDAVKVT QRIISGVYSG VTTVELDNLA  60
   61 AETCAYMTTV HPDYATLAAR IAISNLHKQT TKQFSKVIED LHDWINPATG KHAPMISDEI 120
  121 YNIVMENKDT LNSAIVYDRD FQYTYFGFKT LERSYLLRLN GEVAERPQHL VMRVALGIHG 180
  181 SDIESVLKTY NLMSLRYFTH ASPTLFNAGT PHPQMSSCFL IAMKDDSIEG IYDTLKECAM 240
  241 ISKTAGGVGL HINNIRSTGS YIAGTNGTSN GLIPMIRVFN NTARYVDQGG NKRPGAFALF 300
  301 LEPWHADIFD FVDIRKTHGK EEIRARDLFP ALWIPDLFMK RVQEDGPWTL FSPSAAPGLD 360
  361 DVWGDEFEEL YTRYEREGRG KTIKAQKLWY AILQAQTETG TPFMVYKDAC NRKTNQQNLG 420
  421 TIKSSNLCCE IVEYSSPDET AVCNLASIAL PAFVEVSEDG KTASYNFERL HEIAKVITHN 480
  481 LNRVIDRNYY PVPEARNSNM KHRPIALGVQ GLADTYMMLR LPFESEEAQT LNKQIFETIY 540
  541 HATLEASCEL AQKEGKYSTF EGSPASKGIL QFDMWNAKPF GMWDWETLRK DIVKHGLRNS 600
  601 LTMAPMPTAS TSQILGYNEC FEPVTSNMYS RRVLSGEFQV VNPYLLRDLV DLGIWDDSMK 660
  661 QYLITQNGSI QGLPNVPQEL KELYKTVWEI SQKTIINMAA DRAIYIDQSH SLNLFLQAPS 720
  721 MGKITSMHFY GWKKGLKTGM YYLRTQAASA AIQFTIDQEV ADQAATHIAS VSELDRPVYV 780
  781 PKGTKFSEQK AASALTESSD NEKDASPVPS EQSSVSSAMS NVKLEDSVAP AVPTETIKED 840
  841 SDEKKCDIYN EKVIACTAPT PEACESCSG

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) RNR1 RNR3
    View Details (MIPS) Mewes HW, et al. (2004) RNR1 RNR2 RNR3 RNR4
    View Details Krogan NJ, et al. (2006) RNR1 RNR2 RNR3 RNR4
    View Details Ho Y, et al. (2002) ARP2 CCE1 CYS4 HTB1 MAS1 MAS2 MKT1 RNQ1 RNR1 RNR3 RPN12 RPN9 YNL134C
    View Details Qiu et al. (2008) RNR1 RNR2 RNR3 RNR4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen RNR3 NFI1 2 Unpublished Fields Lab Data
    View Screen RNR3 MRC1 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data RNR3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..766] PSI-BLAST 1000.0 R1 subunit of ribonucleotide reductase, N-terminal domain; R1 subunit of ribonucleotide reductase, C-terminal domain
    2 View Details [767..869] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle