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View Structure Prediction Details

Protein: STH1
Organism: Saccharomyces cerevisiae
Length: 1359 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for STH1.

Description E-value Query
Range		 Subject
Range
STH1 - ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic g...
STH1_YEAST - Nuclear protein STH1/NPS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=STH1 PE=1 SV=1
 0.0 [1..1359] [1..1359]
gi|447739 - gi|447739|prf||1915304A nylB upstream ORF
 0.0 [19..1358] [328..1656]
gi|996018, gi|45... - gi|996018|emb|CAA62831.1| BRG1 protein [Gallus gallus], gi|45384232|ref|NP_990390.1| BRG1 protein [G...
 0.0 [45..1212] [330..1534]
kis-PA - The gene kismet is referred to in FlyBase by the symbol Dmel\kis (CG3696, FBgn0086902). It is a prot...
 0.0 [3..1256] [1586..2825]
SMARCA4 - SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
 0.0 [45..1212] [332..1550]

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Predicted Domain #1
Region A:
Residues: [1-233] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLQEQSELMS TVMNNTPTTV AALAAVAAAS ETNGKLGSEE QPEITIPKPR SSAQLEQLLY  60
   61 RYRAIQNHPK ENKLEIKAIE DTFRNISRDQ DIYETKLDTL RKSIDKGFQY DEDLLNKHLV 120
  121 ALQLLEKDTD VPDYFLDLPD TKNDNTTAIE VDYSEKKPIK ISADFNAKAK SLGLESKFSN 180
  181 ATKTALGDPD TEIRISARIS NRINELERLP ANLGTYSLDD CLEFITKDDL SSR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 2.41724497205118 bayes_pls_golite062009
protein binding 1.23494952402126 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [234-277] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDTFKIKALV ELKSLKLLTK QKSIRQKLIN NVASQAHHNI PYLR

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [367-431] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QKRIERTAKQ RLAALKSNDE EAYLKLLDQT KDTRITQLLR QTNSFLDSLS EAVRAQQNEA  60
   61 KILHG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.0
Match: 1gm5A_
Description: RecG, N-terminal domain; RecG "wedge" domain; RecG helicase domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [278-366] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DSPFTAAAQR SVQIRSKVIV PQTVRLAEEL ERQQLLEKRK KERNLHLQKI NSIIDFIKER  60
   61 QSEQWSRQER CFQFGRLGAS LHNQMEKDE

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [432-649] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EEVQPITDEE REKTDYYEVA HRIKEKIDKQ PSILVGGTLK EYQLRGLEWM VSLYNNHLNG  60
   61 ILADEMGLGK TIQSISLITY LYEVKKDIGP FLVIVPLSTI TNWTLEFEKW APSLNTIIYK 120
  121 GTPNQRHSLQ HQIRVGNFDV LLTTYEYIIK DKSLLSKHDW AHMIIDEGHR MKNAQSKLSF 180
  181 TISHYYRTRN RLILTGTPLQ NNLPELWALL NFVLPKIF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.0
Match: 1gm5A_
Description: RecG, N-terminal domain; RecG "wedge" domain; RecG helicase domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.64537357529343 bayes_pls_golite062009
ATP-dependent DNA helicase activity 2.4348680404207 bayes_pls_golite062009
nucleic acid binding 2.21184938313192 bayes_pls_golite062009
pyrophosphatase activity 2.13284212711072 bayes_pls_golite062009
DNA binding 2.12258000781149 bayes_pls_golite062009
transcription regulator activity 2.09345198747025 bayes_pls_golite062009
helicase activity 1.70242731830224 bayes_pls_golite062009
structure-specific DNA binding 1.2539059700735 bayes_pls_golite062009
DNA-dependent ATPase activity 1.2155186842031 bayes_pls_golite062009
motor activity 1.19366988459523 bayes_pls_golite062009
purine NTP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
ATP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
microtubule motor activity 1.170087579765 bayes_pls_golite062009
double-stranded DNA binding 1.117585097627 bayes_pls_golite062009
transcription elongation regulator activity 1.11383295816593 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.07968294254548 bayes_pls_golite062009
histone acetyltransferase activity 1.05990253628867 bayes_pls_golite062009
lysine N-acetyltransferase activity 1.05990253628867 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
transcription factor activity 0.887108427603557 bayes_pls_golite062009
DNA helicase activity 0.72881469450553 bayes_pls_golite062009
cytoskeletal protein binding 0.568484017802328 bayes_pls_golite062009
single-stranded DNA binding 0.568457189190858 bayes_pls_golite062009
mismatched DNA binding 0.31144582840038 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.243902356228423 bayes_pls_golite062009
RNA helicase activity 0.18426050934025 bayes_pls_golite062009
protein binding 0.170837278876362 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.147579541298736 bayes_pls_golite062009
RNA-dependent ATPase activity 0.14606996093053 bayes_pls_golite062009
ATP-dependent RNA helicase activity 0.13050483816765 bayes_pls_golite062009
nucleotide binding 0.114848452385726 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.113504049290503 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.111293884322157 bayes_pls_golite062009
purine nucleotide binding 0.10713474095071 bayes_pls_golite062009
purine ribonucleotide binding 0.0916519414118148 bayes_pls_golite062009
ribonucleotide binding 0.0915913646217636 bayes_pls_golite062009
actin binding 0.0206144204131673 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [650-707] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSAKTFEDWF NTPFANTGTQ EKLELTEEET LLIIRRLHKV LRPFLLRRLK KEVEKDLP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.626 0.901 DNA helicase activity a.4.5 "Winged helix" DNA-binding domain

Predicted Domain #5
Region A:
Residues: [708-919] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DKVEKVIKCK LSGLQQQLYQ QMLKHNALFV GAGTEGATKG GIKGLNNKIM QLRKICNHPF  60
   61 VFDEVEGVVN PSRGNSDLLF RVAGKFELLD RVLPKFKASG HRVLMFFQMT QVMDIMEDFL 120
  121 RMKDLKYMRL DGSTKTEERT EMLNAFNAPD SDYFCFLLST RAGGLGLNLQ TADTVIIFDT 180
  181 DWNPHQDLQA QDRAHRIGQK NEVRILRLIT TD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.0
Match: 1hv8A_
Description: Putative DEAD box RNA helicase
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [920-1146] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVEEVILERA MQKLDIDGKV IQAGKFDNKS TAEEQEAFLR RLIESETNRD DDDKAELDDD  60
   61 ELNDTLARSA DEKILFDKID KERMNQERAD AKAQGLRVPP PRLIQLDELP KVFREDIEEH 120
  121 FKKEDSEPLG RIRQKKRVYY DDGLTEEQFL EAVEDDNMSL EDAIKKRREA RERRRLRQNG 180
  181 TKENEIETLE NTPEASETSL IENNSFTAAV DEETNADKET TASRSKR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [1147-1227] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSSRKKRTIS IVTAEDKENT QEESTSQENG GAKVEEEVKS SSVEIINGSE SKKKKPKLTV  60
   61 KIKLNKTTVL ENNDGKRAEE K

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [1228-1359] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PESKSPAKKT AAKKTKTKSK SLGIFPTVEK LVEEMREQLD EVDSHPRTSI FEKLPSKRDY  60
   61 PDYFKVIEKP MAIDIILKNC KNGTYKTLEE VRQALQTMFE NARFYNEEGS WVYVDADKLN 120
  121 EFTDEWFKEH SS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 72.522879
Match: 1e6iA_
Description: GCN5
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle