| Protein: | STH1 |
| Organism: | Saccharomyces cerevisiae |
| Length: | 1359 amino acids |
| Reference: | Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for STH1.
| Description | E-value | Query Range |
Subject Range |
|
|
0.0 | [1..1359] | [1..1359] |
|
|
0.0 | [19..1358] | [328..1656] |
|
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0.0 | [45..1212] | [330..1534] |
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0.0 | [3..1256] | [1586..2825] |
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0.0 | [45..1212] | [332..1550] |
|
Region A: Residues: [1-233] |
1 11 21 31 41 51
| | | | | |
1 MLQEQSELMS TVMNNTPTTV AALAAVAAAS ETNGKLGSEE QPEITIPKPR SSAQLEQLLY 60
61 RYRAIQNHPK ENKLEIKAIE DTFRNISRDQ DIYETKLDTL RKSIDKGFQY DEDLLNKHLV 120
121 ALQLLEKDTD VPDYFLDLPD TKNDNTTAIE VDYSEKKPIK ISADFNAKAK SLGLESKFSN 180
181 ATKTALGDPD TEIRISARIS NRINELERLP ANLGTYSLDD CLEFITKDDL SSR
|
| Detection Method: |  |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
Found no structure predictions for this domain.
| Term | Confidence | Notes |
| binding | 2.41724497205118 | bayes_pls_golite062009 |
| protein binding | 1.23494952402126 | bayes_pls_golite062009 |
|
Region A: Residues: [234-277] |
1 11 21 31 41 51
| | | | | |
1 MDTFKIKALV ELKSLKLLTK QKSIRQKLIN NVASQAHHNI PYLR
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|
Region B: Residues: [367-431] |
1 11 21 31 41 51
| | | | | |
1 QKRIERTAKQ RLAALKSNDE EAYLKLLDQT KDTRITQLLR QTNSFLDSLS EAVRAQQNEA 60
61 KILHG
|
| Detection Method: | |
| Confidence: | 4.0 |
| Match: | 1gm5A_ |
| Description: | RecG, N-terminal domain; RecG "wedge" domain; RecG helicase domain |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [278-366] |
1 11 21 31 41 51
| | | | | |
1 DSPFTAAAQR SVQIRSKVIV PQTVRLAEEL ERQQLLEKRK KERNLHLQKI NSIIDFIKER 60
61 QSEQWSRQER CFQFGRLGAS LHNQMEKDE
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|
Region B: Residues: [432-649] |
1 11 21 31 41 51
| | | | | |
1 EEVQPITDEE REKTDYYEVA HRIKEKIDKQ PSILVGGTLK EYQLRGLEWM VSLYNNHLNG 60
61 ILADEMGLGK TIQSISLITY LYEVKKDIGP FLVIVPLSTI TNWTLEFEKW APSLNTIIYK 120
121 GTPNQRHSLQ HQIRVGNFDV LLTTYEYIIK DKSLLSKHDW AHMIIDEGHR MKNAQSKLSF 180
181 TISHYYRTRN RLILTGTPLQ NNLPELWALL NFVLPKIF
|
| Detection Method: | |
| Confidence: | 4.0 |
| Match: | 1gm5A_ |
| Description: | RecG, N-terminal domain; RecG "wedge" domain; RecG helicase domain |
| Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| binding | 2.64537357529343 | bayes_pls_golite062009 |
| ATP-dependent DNA helicase activity | 2.4348680404207 | bayes_pls_golite062009 |
| nucleic acid binding | 2.21184938313192 | bayes_pls_golite062009 |
| pyrophosphatase activity | 2.13284212711072 | bayes_pls_golite062009 |
| DNA binding | 2.12258000781149 | bayes_pls_golite062009 |
| transcription regulator activity | 2.09345198747025 | bayes_pls_golite062009 |
| helicase activity | 1.70242731830224 | bayes_pls_golite062009 |
| structure-specific DNA binding | 1.2539059700735 | bayes_pls_golite062009 |
| DNA-dependent ATPase activity | 1.2155186842031 | bayes_pls_golite062009 |
| motor activity | 1.19366988459523 | bayes_pls_golite062009 |
| purine NTP-dependent helicase activity | 1.19311444180077 | bayes_pls_golite062009 |
| ATP-dependent helicase activity | 1.19311444180077 | bayes_pls_golite062009 |
| microtubule motor activity | 1.170087579765 | bayes_pls_golite062009 |
| double-stranded DNA binding | 1.117585097627 | bayes_pls_golite062009 |
| transcription elongation regulator activity | 1.11383295816593 | bayes_pls_golite062009 |
| general RNA polymerase II transcription factor activity | 1.07968294254548 | bayes_pls_golite062009 |
| histone acetyltransferase activity | 1.05990253628867 | bayes_pls_golite062009 |
| lysine N-acetyltransferase activity | 1.05990253628867 | bayes_pls_golite062009 |
| catalytic activity | 1.00104173493322 | bayes_pls_golite062009 |
| transcription factor activity | 0.887108427603557 | bayes_pls_golite062009 |
| DNA helicase activity | 0.72881469450553 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 0.568484017802328 | bayes_pls_golite062009 |
| single-stranded DNA binding | 0.568457189190858 | bayes_pls_golite062009 |
| mismatched DNA binding | 0.31144582840038 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity | 0.243902356228423 | bayes_pls_golite062009 |
| RNA helicase activity | 0.18426050934025 | bayes_pls_golite062009 |
| protein binding | 0.170837278876362 | bayes_pls_golite062009 |
| nucleoside-triphosphatase activity | 0.147579541298736 | bayes_pls_golite062009 |
| RNA-dependent ATPase activity | 0.14606996093053 | bayes_pls_golite062009 |
| ATP-dependent RNA helicase activity | 0.13050483816765 | bayes_pls_golite062009 |
| nucleotide binding | 0.114848452385726 | bayes_pls_golite062009 |
| hydrolase activity, acting on acid anhydrides | 0.113504049290503 | bayes_pls_golite062009 |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 0.111293884322157 | bayes_pls_golite062009 |
| purine nucleotide binding | 0.10713474095071 | bayes_pls_golite062009 |
| purine ribonucleotide binding | 0.0916519414118148 | bayes_pls_golite062009 |
| ribonucleotide binding | 0.0915913646217636 | bayes_pls_golite062009 |
| actin binding | 0.0206144204131673 | bayes_pls_golite062009 |
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Region A: Residues: [650-707] |
1 11 21 31 41 51
| | | | | |
1 NSAKTFEDWF NTPFANTGTQ EKLELTEEET LLIIRRLHKV LRPFLLRRLK KEVEKDLP
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| Detection Method: | |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
| MCM Score |
GO Score |
GO Term |
SCOP Match |
SCOP Description | ||
| View | Download | 0.626 | 0.901 | DNA helicase activity | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.486 | 0.901 | DNA helicase activity | a.24.13 | Domain of the SRP/SRP receptor G-proteins |
| View | Download | 0.489 | 0.901 | DNA helicase activity | a.157.1 | Skp1 dimerisation domain-like |
| View | Download | 0.461 | 0.901 | DNA helicase activity | a.24.17 | Group V grass pollen allergen |
| View | Download | 0.579 | 0.901 | DNA helicase activity | a.12.1 | Kix domain of CBP (creb binding protein) |
| View | Download | 0.430 | 0.901 | DNA helicase activity | a.180.1 | N-terminal, cytoplasmic domain of anti-sigmaE factor RseA |
| View | Download | 0.424 | 0.901 | DNA helicase activity | a.60.2 | RuvA domain 2-like |
| View | Download | 0.421 | 0.901 | DNA helicase activity | a.28.3 | Retrovirus capsid protein C-terminal domain |
| View | Download | 0.407 | 0.901 | DNA helicase activity | a.35.1 | lambda repressor-like DNA-binding domains |
| View | Download | 0.381 | 0.901 | DNA helicase activity | a.65.1 | Annexin |
| View | Download | 0.378 | 0.901 | DNA helicase activity | a.16.1 | S15/NS1 RNA-binding domain |
| View | Download | 0.370 | 0.901 | DNA helicase activity | a.4.1 | Homeodomain-like |
| View | Download | 0.364 | 0.901 | DNA helicase activity | a.22.1 | Histone-fold |
| View | Download | 0.351 | 0.901 | DNA helicase activity | a.35.1 | lambda repressor-like DNA-binding domains |
| View | Download | 0.348 | 0.901 | DNA helicase activity | a.4.1 | Homeodomain-like |
| View | Download | 0.346 | 0.901 | DNA helicase activity | a.77.1 | DEATH domain |
| View | Download | 0.341 | 0.901 | DNA helicase activity | a.101.1 | Uteroglobin-like |
| View | Download | 0.337 | 0.901 | DNA helicase activity | a.64.1 | Saposin |
| View | Download | 0.298 | 0.901 | DNA helicase activity | a.126.1 | Serum albumin-like |
| View | Download | 0.297 | 0.901 | DNA helicase activity | d.58.44 | Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains |
| View | Download | 0.291 | 0.901 | DNA helicase activity | a.2.7 | tRNA-binding arm |
| View | Download | 0.284 | 0.901 | DNA helicase activity | a.179.1 | Replisome organizer (g39p helicase loader/inhibitor protein) |
| View | Download | 0.267 | 0.901 | DNA helicase activity | a.7.6 | Ribosomal protein S20 |
| View | Download | 0.264 | 0.901 | DNA helicase activity | a.4.9 | Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 |
| View | Download | 0.264 | 0.901 | DNA helicase activity | a.108.1 | Ribosomal protein L7/12, oligomerisation (N-terminal) domain |
| View | Download | 0.256 | 0.901 | DNA helicase activity | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.247 | 0.901 | DNA helicase activity | a.4.8 | Ribosomal protein S18 |
| View | Download | 0.238 | 0.901 | DNA helicase activity | b.84.2 | Rudiment single hybrid motif |
| View | Download | 0.238 | 0.901 | DNA helicase activity | a.64.1 | Saposin |
| View | Download | 0.237 | 0.901 | DNA helicase activity | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.220 | 0.901 | DNA helicase activity | d.48.1 | RecA protein, C-terminal domain |
| View | Download | 0.216 | 0.901 | DNA helicase activity | a.24.13 | Domain of the SRP/SRP receptor G-proteins |
| View | Download | 0.210 | 0.901 | DNA helicase activity | a.16.1 | S15/NS1 RNA-binding domain |
| View | Download | 0.206 | 0.901 | DNA helicase activity | a.64.1 | Saposin |
| View | Download | 0.206 | 0.901 | DNA helicase activity | a.17.1 | p8-MTCP1 |
|
Region A: Residues: [708-919] |
1 11 21 31 41 51
| | | | | |
1 DKVEKVIKCK LSGLQQQLYQ QMLKHNALFV GAGTEGATKG GIKGLNNKIM QLRKICNHPF 60
61 VFDEVEGVVN PSRGNSDLLF RVAGKFELLD RVLPKFKASG HRVLMFFQMT QVMDIMEDFL 120
121 RMKDLKYMRL DGSTKTEERT EMLNAFNAPD SDYFCFLLST RAGGLGLNLQ TADTVIIFDT 180
181 DWNPHQDLQA QDRAHRIGQK NEVRILRLIT TD
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| Detection Method: | |
| Confidence: | 3.0 |
| Match: | 1hv8A_ |
| Description: | Putative DEAD box RNA helicase |
Matching Structure (courtesy of the PDB): |
|
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Region A: Residues: [920-1146] |
1 11 21 31 41 51
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1 SVEEVILERA MQKLDIDGKV IQAGKFDNKS TAEEQEAFLR RLIESETNRD DDDKAELDDD 60
61 ELNDTLARSA DEKILFDKID KERMNQERAD AKAQGLRVPP PRLIQLDELP KVFREDIEEH 120
121 FKKEDSEPLG RIRQKKRVYY DDGLTEEQFL EAVEDDNMSL EDAIKKRREA RERRRLRQNG 180
181 TKENEIETLE NTPEASETSL IENNSFTAAV DEETNADKET TASRSKR
|
| Detection Method: | |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
Found no structure predictions for this domain.
|
Region A: Residues: [1147-1227] |
1 11 21 31 41 51
| | | | | |
1 RSSRKKRTIS IVTAEDKENT QEESTSQENG GAKVEEEVKS SSVEIINGSE SKKKKPKLTV 60
61 KIKLNKTTVL ENNDGKRAEE K
|
| Detection Method: | |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
| MCM Score |
SCOP Match |
SCOP Description | ||
| View | Download | 0.381 | b.1.18 | E set domains |
| View | Download | 0.378 | d.51.1 | Eukaryotic type KH-domain (KH-domain type I) |
| View | Download | 0.409 | b.34.5 | Translation proteins SH3-like domain |
| View | Download | 0.329 | d.74.2 | C-terminal domain of arginine repressor |
| View | Download | 0.303 | b.1.1 | Immunoglobulin |
| View | Download | 0.274 | c.47.1 | Thioredoxin-like |
| View | Download | 0.273 | c.47.1 | Thioredoxin-like |
| View | Download | 0.272 | d.68.7 | R3H domain |
| View | Download | 0.229 | b.1.2 | Fibronectin type III |
| View | Download | 0.210 | d.74.1 | Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH) |
| View | Download | 0.202 | b.40.2 | Bacterial enterotoxins |
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Region A: Residues: [1228-1359] |
1 11 21 31 41 51
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1 PESKSPAKKT AAKKTKTKSK SLGIFPTVEK LVEEMREQLD EVDSHPRTSI FEKLPSKRDY 60
61 PDYFKVIEKP MAIDIILKNC KNGTYKTLEE VRQALQTMFE NARFYNEEGS WVYVDADKLN 120
121 EFTDEWFKEH SS
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| Detection Method: | |
| Confidence: | 72.522879 |
| Match: | 1e6iA_ |
| Description: | GCN5 |
Matching Structure (courtesy of the PDB): |
|
