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Protein Overview: DOT6

General Information:
Name(s) found: DOT6 / YER088C [SGD]
Description(s) found:
Found 24 descriptions.
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  • Protein involved in rRNA and ribosome biogenesis; binds polymerase A and C motif; subunit of the RPD3L histone deacetylase complex; similar to Tod6p; has chromatin specific SANT domain; involved in telomeric gene silencing and filamentation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 670 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: filamentous growth [IGILink to PubMed article]
    unidimensional cell growth [IMPLink to PubMed article]
    chromatin silencing at rDNA [IGILink to PubMed article]
    chromatin silencing at telomere [IGILink to PubMed article]
    regulation of transcription from RNA polymerase II promoter [IGILink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSISTSLNSA SIHLSSMDTH PQLHSLTRQP HSSSTAMSKN EAQESSPSLP ASSSSSTSAS  60
   61 ASASSKNSSK NPSSWDPQDD LLLRHLKEVK KMGWKDISQY FPNRTPNACQ FRWRRLKSGN 120
  121 LKSNKTALID INTYTGPLKI THGDETANAQ QKPSKKVEEN VLTEDTAEFT TTSSIPIPSR 180
  181 KTSLPSFHAS MSFSQSPSNV TPTTIVSNAA SSMPFAPPTL PAALPHHPHQ HLHHHPHHKT 240
  241 LKPRSNSHSF TNSLNQDPIV RSNDEEKYGF IPKVFVRSRR SSFAYPQQVA ITTTPSSPNS 300
  301 SHVLLSSKSR RGSLANWSRR SSFNVSSNNT SRRSSMILAP NSVSNIFNVN NSGSNTASTS 360
  361 NTNSRRESVI KKEFQQRLNN LSNSGGPTSN NGPIFPNSYT FMDLPHSSSV SSSSTLHKSK 420
  421 RGSFSGHSMK SSCNPTNLWS KDEDALLMEN KKRNLSVMEL SILLPQRTEV EIQWRLNALS 480
  481 SDADMLSPTH SPQKTLSKKT CPRMFKSGST TDDDKGSDKE DVMGDGSNDD DEDNVDPLHR 540
  541 AKQSSNKTVF SSSSSNISSK DVSPDPIFSP DPADDSSNTS DAGSRCTITS DTSSSAATMN 600
  601 RTPNSKNPQD IALLNNFRSE AITPRPKPSS TTTSITTETT NNMINHSSST TTTTNNSPLP 660
  661 SINTIFKDML

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) DOT6 IBD2 NST1 YKL075C YOL159C-A
    View Details Gavin AC, et al. (2002) ABF2 CKA1 CKA2 CKB1 CKB2 CTI6 DEP1 DOT6 EAF3 ECM16 HTA2 IOC3 ISW1 MED4 NHP10 NRD1 PHO23 RCO1 RPD3 RSC8 RXT2 RXT3 SAP30 SDS3 SIN3 STO1 TOP1 TUP1 UME1 UME6 VPS1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data DOT6 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..69] PSI-BLAST 61.221849 c-Myb, DNA-binding domain
    2 View Details [70..120] PSI-BLAST 61.221849 c-Myb, DNA-binding domain
    3 View Details [121..173] PSI-BLAST 61.221849 c-Myb, DNA-binding domain
    4 View Details [174..370] MSA 4.301997 View MSA. No confident structure predictions are available.
    5 View Details [371..670] ORFEUS 7.08 Microbial transglutaminase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • protein deacetylase activity
    		•  4.51773576226152 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.51452285155271 bayes_pls_golite062009
  • histone deacetylase activity
    		•  4.45890455415069 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • deacetylase activity
    		•  3.80637060479832 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.55154985983449 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.16896789933192 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
    		•  2.78048742312781 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.41271657675151 bayes_pls_golite062009
  • transcription activator activity
    		•  1.77700860354597 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.73068440195944 bayes_pls_golite062009
  • chromatin binding
    		•  1.68956710349366 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.62096064323298 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.49423102874486 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • protein binding
    		•  0.830419844171551 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.2679415219517 bayes_pls_golite062009
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • protein deacetylase activity
    		•  4.51773576226152 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.51452285155271 bayes_pls_golite062009
  • histone deacetylase activity
    		•  4.45890455415069 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • deacetylase activity
    		•  3.80637060479832 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.55154985983449 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.16896789933192 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
    		•  2.78048742312781 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.41271657675151 bayes_pls_golite062009
  • transcription activator activity
    		•  1.77700860354597 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.73068440195944 bayes_pls_golite062009
  • chromatin binding
    		•  1.68956710349366 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.62096064323298 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.49423102874486 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • protein binding
    		•  0.830419844171551 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.2679415219517 bayes_pls_golite062009
    4 No functions predicted.
    5
    Term Confidence Notes
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
    		•  3.20223170299093 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.1624285999321 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.07259265336278 bayes_pls_golite062009
  • DNA binding
    		•  1.95965886684273 bayes_pls_golite062009
  • binding
    		•  1.92915144283226 bayes_pls_golite062009
  • transcription factor activity
    		•  1.21117523308379 bayes_pls_golite062009
  • catalytic activity
    		•  0.995453662223124 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  0.892482498372301 bayes_pls_golite062009
  • protein binding
    		•  0.834719536847984 bayes_pls_golite062009
  • structural molecule activity
    		•  0.151239297413308 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  0.114864260575279 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.0467669397165897 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.87

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle