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View Structure Prediction Details

Protein: DOT6
Organism: Saccharomyces cerevisiae
Length: 670 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DOT6.

Description E-value Query
Range		 Subject
Range
DOT6 - Protein involved in rRNA and ribosome biogenesis; binds polymerase A and C motif; subunit of the RPD...
DOT6_YEAST - Transcriptional regulatory protein DOT6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=...
 0.0 [1..670] [1..670]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 2.0E-85 [67..440] [10..372]
gi|17065086 - gi|17065086|gb|AAL32697.1| myb-related protein M4 [Arabidopsis thaliana]
 3.0E-71 [67..355] [9..300]
gi|45504408, gi|... - gi|45504408|emb|CAF04478.1| unnamed protein product [Homo sapiens], gi|45502003|emb|CAE55168.1| v-my...
 2.0E-68 [16..243] [33..260]
gi|11066265 - gi|11066265|gb|AAG28526.1|AF198499_1 anther-specific myb-related protein 1 [Nicotiana tabacum]
 2.0E-67 [70..365] [20..306]
MYB_XENLA - Transcriptional activator Myb OS=Xenopus laevis GN=myb PE=2 SV=1
 2.0E-67 [15..311] [29..359]

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Predicted Domain #1
Region A:
Residues: [1-69] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSISTSLNSA SIHLSSMDTH PQLHSLTRQP HSSSTAMSKN EAQESSPSLP ASSSSSTSAS  60
   61 ASASSKNSS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 61.221849
Match: 1h88C_
Description: c-Myb, DNA-binding domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [70-120] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KNPSSWDPQD DLLLRHLKEV KKMGWKDISQ YFPNRTPNAC QFRWRRLKSG N

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 61.221849
Match: 1h88C_
Description: c-Myb, DNA-binding domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
protein deacetylase activity 4.51773576226152 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
histone deacetylase activity 4.45890455415069 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
deacetylase activity 3.80637060479832 bayes_pls_golite062009
transcription repressor activity 3.55154985983449 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 2.78048742312781 bayes_pls_golite062009
sequence-specific DNA binding 2.41271657675151 bayes_pls_golite062009
transcription activator activity 1.77700860354597 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.62096064323298 bayes_pls_golite062009
transcription corepressor activity 1.49423102874486 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009
transcription coactivator activity 0.2679415219517 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [121-173] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKSNKTALID INTYTGPLKI THGDETANAQ QKPSKKVEEN VLTEDTAEFT TTS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 61.221849
Match: 1h88C_
Description: c-Myb, DNA-binding domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
protein deacetylase activity 4.51773576226152 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
histone deacetylase activity 4.45890455415069 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
deacetylase activity 3.80637060479832 bayes_pls_golite062009
transcription repressor activity 3.55154985983449 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 2.78048742312781 bayes_pls_golite062009
sequence-specific DNA binding 2.41271657675151 bayes_pls_golite062009
transcription activator activity 1.77700860354597 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.62096064323298 bayes_pls_golite062009
transcription corepressor activity 1.49423102874486 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009
transcription coactivator activity 0.2679415219517 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [174-370] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SIPIPSRKTS LPSFHASMSF SQSPSNVTPT TIVSNAASSM PFAPPTLPAA LPHHPHQHLH  60
   61 HHPHHKTLKP RSNSHSFTNS LNQDPIVRSN DEEKYGFIPK VFVRSRRSSF AYPQQVAITT 120
  121 TPSSPNSSHV LLSSKSRRGS LANWSRRSSF NVSSNNTSRR SSMILAPNSV SNIFNVNNSG 180
  181 SNTASTSNTN SRRESVI

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [371-670] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKEFQQRLNN LSNSGGPTSN NGPIFPNSYT FMDLPHSSSV SSSSTLHKSK RGSFSGHSMK  60
   61 SSCNPTNLWS KDEDALLMEN KKRNLSVMEL SILLPQRTEV EIQWRLNALS SDADMLSPTH 120
  121 SPQKTLSKKT CPRMFKSGST TDDDKGSDKE DVMGDGSNDD DEDNVDPLHR AKQSSNKTVF 180
  181 SSSSSNISSK DVSPDPIFSP DPADDSSNTS DAGSRCTITS DTSSSAATMN RTPNSKNPQD 240
  241 IALLNNFRSE AITPRPKPSS TTTSITTETT NNMINHSSST TTTTNNSPLP SINTIFKDML 300
  301

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.08
Match: 1iu4A
Description: Microbial transglutaminase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 3.20223170299093 bayes_pls_golite062009
transcription regulator activity 2.1624285999321 bayes_pls_golite062009
nucleic acid binding 2.07259265336278 bayes_pls_golite062009
DNA binding 1.95965886684273 bayes_pls_golite062009
binding 1.92915144283226 bayes_pls_golite062009
transcription factor activity 1.21117523308379 bayes_pls_golite062009
catalytic activity 0.995453662223124 bayes_pls_golite062009
cysteine-type peptidase activity 0.892482498372301 bayes_pls_golite062009
protein binding 0.834719536847984 bayes_pls_golite062009
structural molecule activity 0.151239297413308 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.114864260575279 bayes_pls_golite062009
cytoskeletal protein binding 0.0467669397165897 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle