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Protein Overview: MAF1

General Information:
Name(s) found: MAF1 / YDR005C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Negative regulator of RNA polymerase III; component of several signaling pathways that repress polymerase III transcription in response to changes in cellular environment; targets the initiation factor TFIIIB [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 395 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article]
    Biological Process: negative regulation of transcription from RNA polymerase III promoter [IDALink to PubMed article][IMPLink to PubMed articleLink to PubMed article][IPILink to PubMed articleLink to PubMed article]
    Molecular Function: transcription regulator activity [IDALink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKFIDELDIE RVNQTLNFET NDCKIVGSCD IFTTKAVASD RKLYKTIDQH LDTILQENEN  60
   61 YNATLQQQLA APETNQSPCS SPFYSNRRDS NSFWEQKRRI SFSEYNSNNN TNNSNGNSSN 120
  121 NNNYSGPNGS SPATFPKSAK LNDQNLKELV SNYDSGSMSS SSLDSSSKND ERIRRRSSSS 180
  181 ISSFKSGKSS NNNYSSGTAT NNVNKRRKSS INERPSNLSL GPFGPINEPS SRKIFAYLIA 240
  241 ILNASYPDHD FSSVEPTDFV KTSLKTFISK FENTLYSLGR QPEEWVWEVI NSHMTLSDCV 300
  301 LFQYSPSNSF LEDEPGYLWN LIGFLYNRKR KRVAYLYLIC SRLNSSTGEV EDALAKKPQG 360
  361 KLIIDDGSNE YEGEYDFTYD ENVIDDKSDQ EESLQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) MAF1 RPC31 RPC37
    View Details Krogan NJ, et al. (2006) BDP1 CDC14 COY1 FAR7 MAF1 RET1 RPA12 RPA135 RPA14 RPA190 RPA34 RPA43 RPA49 RPC10 RPC11 RPC17 RPC19 RPC25 RPC31 RPC34 RPC37 RPC40 RPC53 RPC82 RPO31 YDL144C YIR024C
    View Details Gavin AC, et al. (2002) AMS1 ASC1 CDC14 DHH1 FBA1 MAF1 RET1 RPA12 RPA135 RPA190 RPA43 RPA49 RPB10 RPB5 RPB8 RPC11 RPC17 RPC19 RPC25 RPC31 RPC34 RPC37 RPC40 RPC53 RPC82 RPO26 RPO31 RSC8 SRO7

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data MAF1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..217] deduced N/A No confident structure predictions are available.
    2 View Details [218..395] MSA 6.007964 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle