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Protein Overview: RPA12

General Information:
Name(s) found: RPA12 / YJR063W [SGD]
Description(s) found:
Found 39 descriptions.
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  • RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 125 amino acids

    Gene Ontology:
    Cellular Component: DNA-directed RNA polymerase I complex [TASLink to PubMed article]
    Biological Process: transcription from RNA polymerase I promoter [TAS]
    ribosome biogenesis [RCALink to PubMed article]
    Molecular Function: DNA-directed RNA polymerase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVVGSLIFC LDCGDLLENP NAVLGSNVEC SQCKAIYPKS QFSNLKVVTT TADDAFPSSL  60
   61 RAKKSVVKTS LKKNELKDGA TIKEKCPQCG NEEMNYHTLQ LRSADEGATV FYTCTSCGYK 120
  121 FRTNN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) RPA12 RPA135 RPA14 RPA190 RPA34 RPA43 RPA49 RPB10 RPB5 RPB8 RPC19 RPC40 RPO26
    View Details (MIPS) Mewes HW, et al. (2004) RPA12 RPA135 RPA14 RPA190 RPA34 RPA43 RPA49 RPB10 RPB5 RPB8 RPC10 RPC19 RPC40 RPO26
    View Details Krogan NJ, et al. (2006) BDP1 CDC14 COY1 FAR7 MAF1 RET1 RPA12 RPA135 RPA14 RPA190 RPA34 RPA43 RPA49 RPC10 RPC11 RPC17 RPC19 RPC25 RPC31 RPC34 RPC37 RPC40 RPC53 RPC82 RPO31 YDL144C YIR024C
    View Details Gavin AC, et al. (2006) RPA12 RPA190 RPA43 RPA49 RPC40
    View Details Gavin AC, et al. (2002) AMS1 ASC1 CDC14 DHH1 FBA1 MAF1 RET1 RPA12 RPA135 RPA190 RPA43 RPA49 RPB10 RPB5 RPB8 RPC11 RPC17 RPC19 RPC25 RPC31 RPC34 RPC37 RPC40 RPC53 RPC82 RPO26 RPO31 RSC8 SRO7
    View Details Ho Y, et al. (2002) AIM13 RET1 RPA12 RPA135 RPA190 RPC19 RPC40
    View Details Qiu et al. (2008) RET1 RPA12 RPA135 RPA14 RPA190 RPA34 RPA43 RPA49 RPB10 RPB11 RPB3 RPB4 RPB5 RPB7 RPB8 RPB9 RPC10 RPC17 RPC19 RPC25 RPC31 RPC34 RPC37 RPC40 RPC53 RPC82 RPO21 RPO26 RPO31

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data RPA12 and NOP56 Huh WK, et al. (2003)
    View Data RPA12 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..125] PSI-BLAST 30.522879 Designed zinc finger protein


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle