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Protein Overview: YHL039W

General Information:
Name(s) found: YHL039W [SGD]
Description(s) found:
Found 23 descriptions.
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  • Putative protein of unknown function; contains a SET-domain; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 585 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: ribosome biogenesis [RCALink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MITQTELDNC LQWAQNNGAF IDPKISFRIT EDAGVSAFVN EKFSPKPDQA LIRVPETLLI  60
   61 TSQQALSEFS QAANERSLLN SVTQLYLSKL KFGTDAVHLK SFYKPYLDVL PLHLPQPYFW 120
  121 STDEVMNLHG TDVYLTMRDT LNKLVKEWRM LFQALSIEHS SQDKQFLSLF QENKDSAVVP 180
  181 LEQFCAHING CKLEDSEWNS FVAYLWSYCI FNSRAFPRVI LGRAGTDRTN LNEGFLYPIV 240
  241 DLLNHKNDVP VRWEMNEQNE LCFMSQTTTF SAQDELFNNY GNISNEKCLL NYGFWDSSNK 300
  301 FDFSRLTLKL PSTLVSGLPV DFNKSGNFVT DDGETTILQF SLKISEPLPP VLLALFAYLS 360
  361 KLKSEETPTV RSVLEGIDQL TSVVSQRLLF YKNFKIKTSS TQKLRPHVIK LIKLYYQDNK 420
  421 KILNATTEKL SVLQKKIYSN NKEFSLSFKT IFKNDKIFAN SLLLVFGAIN YEDLITKDCL 480
  481 NDALLLWIVK LINDKSNNQG GFIKQTFKEV SDSIVIEKED VMEFLPFYKK YFPNLSERIP 540
  541 EIYSVGDWGI RQFIVADTAI DRLVWIRKSN KEPIFLMKKA YDLQI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) GCN1 GCN20 RSA4 UTP14 YHL039W
    View Details Ho Y, et al. (2002) NUP133 SEC13 SEC31 YHL039W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data YHL039W Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..298] MSA 31.092997 View MSA. No confident structure predictions are available.
    2 View Details [299..585] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • histone methyltransferase activity
    		•  6.20878333364554 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  6.08778683840554 bayes_pls_golite062009
  • lysine N-methyltransferase activity
    		•  5.45106430536252 bayes_pls_golite062009
  • protein-lysine N-methyltransferase activity
    		•  5.45106430536252 bayes_pls_golite062009
  • histone-lysine N-methyltransferase activity
    		•  5.45106430536252 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  3.98411678860954 bayes_pls_golite062009
  • histone methyltransferase activity (H3-K9 specific)
    		•  3.54138873512018 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  2.69428385009711 bayes_pls_golite062009
  • methyltransferase activity
    		•  2.33114816345072 bayes_pls_golite062009
  • binding
    		•  2.2675356705139 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  2.25175257044903 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.79964884912488 bayes_pls_golite062009
  • chromatin binding
    		•  1.00298380074254 bayes_pls_golite062009
  • protein binding
    		•  0.938282161933492 bayes_pls_golite062009
  • transferase activity
    		•  0.653108419761009 bayes_pls_golite062009
  • catalytic activity
    		•  0.414641636618101 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle