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Protein Overview: NUS1

General Information:
Name(s) found: NUS1 / YDL193W [SGD]
Description(s) found:
Found 32 descriptions.
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  • Putative prenyltransferase, required for cell viability; proposed to be involved in protein trafficking because tet-repressible mutant shows accumulation of hypoglycosylated forms of CPY [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 375 amino acids

    Gene Ontology:
    Cellular Component: nuclear envelope [IDALink to PubMed article]
    lipid particle [IDALink to PubMed articleLink to PubMed article]
    endoplasmic reticulum [IDALink to PubMed article]
    Biological Process: secretory pathway [IMPLink to PubMed article]
    Molecular Function: prenyltransferase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPTMIKKDDK AMEPPNEKPH RKIERDDVPE SSNHIPPPES GVLKGGKVNS KTRALKAVTS  60
   61 IIADADENPQ KKVNNETNGV QKQKTEDLSK RIGKFEYLFY KFLLVLLYIC FGLFRYGQYQ 120
  121 YNKMKLRIFS IIYNHAYTPQ LIRQDVIPLK KIPKRLAAIL EVKPVGDVGG GVTGLLNDAS 180
  181 EIVCWTVSAG IKHLMLYDYD GILQRNVPEL RMEIHSNLAK YFGPAHVPNY AVKIPHSNKI 240
  241 FYNLDGIETE TDVGNEIEAN QEKDKIAIEI SLLSNRDGRE TIVDLTKTMA ELCAVNELSV 300
  301 SDITMDLVDS ELKQLVGPEP DLLLYFGPSL DLQGFPPWHI RLTEFYWEKD NNEVIYSVFI 360
  361 RGLRQYAGCK VNVGK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) GCN1 GSP1 GSP2 NMD5 NUS1 PMA1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data NUS1 Hazbun TR, et al. (2003)
    View Data NUS1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..78] deduced N/A No confident structure predictions are available.
    2 View Details [79..375] PSI-BLAST 77.154902 Undecaprenyl diphosphate synthase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • dehydrodolichyl diphosphate synthase activity
    		•  2.65131914933987 bayes_pls_golite062009
  • transferase activity
    		•  1.42376896518855 bayes_pls_golite062009
  • di-trans,poly-cis-decaprenylcistransferase activity
    		•  1.40194046037281 bayes_pls_golite062009
  • prenyltransferase activity
    		•  1.2102902082955 bayes_pls_golite062009
  • binding
    		•  1.17686415104256 bayes_pls_golite062009
  • catalytic activity
    		•  0.878978773660153 bayes_pls_golite062009
  • protein binding
    		•  0.331797220769091 bayes_pls_golite062009
  • transferase activity, transferring alkyl or aryl (other than methyl) groups
    		•  0.256467886977999 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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    Created and Maintained by: Michael Riffle