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Protein Overview: GEA2

General Information:
Name(s) found: GEA2 / YEL022W [SGD]
Description(s) found:
Found 22 descriptions.
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  • Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs), involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; similar to but not functionally redundant with Gea1p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1459 amino acids

    Gene Ontology:
    Cellular Component: Golgi cis cisterna [IDALink to PubMed article]
    Golgi-associated vesicle [TASLink to PubMed article]
    Biological Process: ER to Golgi vesicle-mediated transport [TASLink to PubMed article]
    retrograde vesicle-mediated transport, Golgi to ER [IGILink to PubMed article]
    intra-Golgi vesicle-mediated transport [TASLink to PubMed article]
    actin cytoskeleton organization [IGILink to PubMed article]
    Molecular Function: ARF guanyl-nucleotide exchange factor activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDREFVTVD PVTIIIKECI NLSTAMRKYS KFTSQSGVAA LLGGGSEIFS NQDDYLAHTF  60
   61 NNLNTNKHND PFLSGFIQLR LMLNKLKNLD NIDSLTILQP FLLIVSTSSI SGYITSLALD 120
  121 SLQKFFTLNI INESSQNYIG AHRATVNALT HCRFEGSQQL SDDSVLLKVV FLLRSIVDSP 180
  181 YGDLLSNSII YDVLQTILSL ACNNRRSEVL RNAAQSTMIA VTVKIFSKLK TIEPVNVNQI 240
  241 YINDESYTND VLKADTIGTN VESKEEGSQE DPIGMKVNNE EAISEDDGIE EEHIHSEKST 300
  301 NGAEQLDIVQ KTTRSNSRIQ AYADDNYGLP VVRQYLNLLL SLIAPENELK HSYSTRIFGL 360
  361 ELIQTALEIS GDRLQLYPRL FTLISDPIFK SILFIIQNTT KLSLLQATLQ LFTTLVVILG 420
  421 NNLQLQIELT LTRIFSILLD DGTANNSSSE NKNKPSIIKE LLIEQISILW TRSPSFFTST 480
  481 FINFDCNLDR ADVSINFLKA LTKLALPESA LTTTESVPPI CLEGLVSLVD DMFDHMKDID 540
  541 REEFGRQKNE MEILKKRDRK TEFIECTNAF NEKPKKGIPM LIEKGFIASD SDKDIAEFLF 600
  601 NNNNRMNKKT IGLLLCHPDK VSLLNEYIRL FDFSGLRVDE AIRILLTKFR LPGESQQIER 660
  661 IIEAFSSAYC ENQDYDPSKI SDNAEDDIST VQPDADSVFI LSYSIIMLNT DLHNPQVKEH 720
  721 MSFEDYSGNL KGCCNHKDFP FWYLDRIYCS IRDKEIVMPE EHHGNEKWFE DAWNNLISST 780
  781 TVITEIKKDT QSVMDKLTPL ELLNFDRAIF KQVGPSIVST LFNIYVVASD DHISTRMITS 840
  841 LDKCSYISAF FDFKDLFNDI LNSIAKGTTL INSSHDDELS TLAFEYGPMP LVQIKFEDTN 900
  901 TEIPVSTDAV RFGRSFKGQL NTVVFFRIIR RNKDPKIFSK ELWLNIVNII LTLYEDLILS 960
  961 PDIFPDLQKR LKLSNLPKPS PEISINKSKE SKGLLSTFAS YLKGDEEPTE EEIKSSKKAM1020
 1021 ECIKSSNIAA SVFGNESNIT ADLIKTLLDS AKTEKNADNS RYFEAELLFI IELTIALFLF1080
 1081 CKEEKELGKF ILQKVFQLSH TKGLTKRTVR RMLTYKILLI SLCADQTEYL SKLINDELLK1140
 1141 KGDIFTQKFF ATNQGKEFLK RLFSLTESEF YRGFLLGNEN FWKFLRKVTA MKEQSESIFE1200
 1201 YLNESIKTDS NILTNENFMW VLGLLDEISS MGAVGNHWEI EYKKLTESGH KIDKENPYKK1260
 1261 SIELSLKSIQ LTSHLLEDNN DLRKNEIFAI IQALAHQCIN PCKQISEFAV VTLEQTLINK1320
 1321 IEIPTNEMES VEELIEGGLL PLLNSSETQE DQKILISSIL TIISNVYLHY LKLGKTSNET1380
 1381 FLKILSIFNK FVEDSDIEKK LQQLILDKKS IEKGNGSSSH GSAHEQTPES NDVEIEATAP1440
 1441 IDDNTDDDNK PKLSDVEKD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CLU1 CRM1 FKS1 GEA2 KAP104 MIR1 YHR020W
    View Details Gavin AC, et al. (2002) ADH1 BMH1 BMH2 CLU1 CRM1 ECM29 FET5 FKS1 FTH1 GCN1 GEA2 GFA1 HRP1 KAP104 KAP123 LCB1 LCB2 LYS12 MIR1 NAB2 RPN3 SAM1 SAM2 YHR020W
    View Details Qiu et al. (2008) GEA1 GEA2 GLO3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data GEA2 and COP1 Huh WK, et al. (2003)
    View Data GEA2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..545] MSA 1.046927 View MSA. No confident structure predictions are available.
    2 View Details [546..626] PSI-BLAST 1294.154902 ARF guanine-exchange factor 2, Gea2
    3 View Details [627..792] PSI-BLAST 1294.154902 ARF guanine-exchange factor 2, Gea2
    4 View Details [793..1114] ORFEUS 9.55 Importin beta
    5 View Details [1115..1320] ORFEUS 9.55 Importin beta
    6 View Details [1321..1404] ORFEUS 9.55 Importin beta
    7 View Details [1405..1459] ORFEUS 7.21 Serum albumin
    8 View Details [1177..1252] deduced N/A No confident structure predictions are available.
    9 View Details [1253..1459] MSA 3.112988 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • ARF guanyl-nucleotide exchange factor activity
    		•  6.57705646633597 bayes_pls_golite062009
  • GTPase regulator activity
    		•  3.37865780899325 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  3.23621073985922 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  3.11224105598265 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  2.75174745190211 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.95578809138334 bayes_pls_golite062009
  • binding
    		•  1.3334812784277 bayes_pls_golite062009
  • protein binding
    		•  0.917306986228715 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.909190013421997 bayes_pls_golite062009
  • phosphoinositide binding
    		•  0.0750646331148792 bayes_pls_golite062009
  • phospholipid binding
    		•  0.0172309833091902 bayes_pls_golite062009
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.59

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle