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Protein Overview: FET5

General Information:
Name(s) found: FET5 / YFL041W [SGD]
Description(s) found:
Found 23 descriptions.
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  • Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 622 amino acids

    Gene Ontology:
    Cellular Component: fungal-type vacuole membrane [IDALink to PubMed article]
    Biological Process: iron ion transport [IMPLink to PubMed article]
    Molecular Function: ferroxidase activity [IGILink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLFYSFVWSV LAASVALAKT HKLNYTASWV TANPDGLHEK RMIGFNGEWP LPDIHVEKGD  60
   61 RVELYLTNGF QDNTATSLHF HGLFQNTSLG NQLQMDGPSM VTQCPIVPGQ TYLYNFTVPE 120
  121 QVGTFWYHAH MGAQYGDGMR GAFIIHDPEE PFEYDHERVI TLSDHYHENY KTVTKEFLSR 180
  181 YNPTGAEPIP QNILFNNTMN VTLDFTPGET YLFRFLNVGL FVSQYIILED HEMSIVEVDG 240
  241 VYVKPNFTDS IYLSAGQRMS VLIKAKDKMP TRNYAMMQIM DETMLDVVPP ELQLNQTIQM 300
  301 RYGHSLPEAR ALNIEDCDLD RATNDFYLEP LIERDLLAHY DHQIVMDVRM VNLGDGVKYA 360
  361 FFNNITYVTP KVPTLTTLLT SGKLASDPRI YGDNINAQLL KHNDIIEVVL NNYDSGRHPF 420
  421 HLHGHNFQIV QKSPGFHVDE AYDESEQDEM TVPYNESAPL QPFPERPMVR DTVVLEPSGH 480
  481 VVLRFRADNP GVWYFHCHVD WHLQQGLASV FIEAPVLLQE REKLNENYLD ICKAADIPVV 540
  541 GNAAGHSNDW FDLKGLPRQP EPLPKGFTTE GYLALIISTI IGVWGLYSIA QYGIGEVIPN 600
  601 DEKVYHTLRE ILAENEIEVS RG

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CAC2 FET5 MSI1 RLF2
    View Details Gavin AC, et al. (2002) ADH1 FET5 FKS1 FTH1 GEA2 KAP123 RPN3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX14 - mixture in detergent (control). Hao Xu, et al. (2010)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data FET5 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..325]
    [525..565]    		 PSI-BLAST 599.9897 Laccase
    2 View Details [326..524] PSI-BLAST 599.9897 Laccase
    3 View Details [566..622] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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