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View Structure Prediction Details

Protein: GEA2
Organism: Saccharomyces cerevisiae
Length: 1459 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GEA2.

Description E-value Query
Range		 Subject
Range
GEA1 - Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs), involved in vesicular transp...
GEA1_YEAST - ARF guanine-nucleotide exchange factor 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN...
 0.0 [7..1413] [10..1407]
GNOM_ARATH - ARF guanine-nucleotide exchange factor GNOM OS=Arabidopsis thaliana GN=GN PE=1 SV=1
 0.0 [12..1405] [32..1380]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [12..1405] [32..1380]
gi|225000702 - gi|225000702|gb|AAI72243.1| ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A...
ARFGEF1 - ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)
 0.0 [211..1386] [300..1474]

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Predicted Domain #1
Region A:
Residues: [1-545] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDREFVTVD PVTIIIKECI NLSTAMRKYS KFTSQSGVAA LLGGGSEIFS NQDDYLAHTF  60
   61 NNLNTNKHND PFLSGFIQLR LMLNKLKNLD NIDSLTILQP FLLIVSTSSI SGYITSLALD 120
  121 SLQKFFTLNI INESSQNYIG AHRATVNALT HCRFEGSQQL SDDSVLLKVV FLLRSIVDSP 180
  181 YGDLLSNSII YDVLQTILSL ACNNRRSEVL RNAAQSTMIA VTVKIFSKLK TIEPVNVNQI 240
  241 YINDESYTND VLKADTIGTN VESKEEGSQE DPIGMKVNNE EAISEDDGIE EEHIHSEKST 300
  301 NGAEQLDIVQ KTTRSNSRIQ AYADDNYGLP VVRQYLNLLL SLIAPENELK HSYSTRIFGL 360
  361 ELIQTALEIS GDRLQLYPRL FTLISDPIFK SILFIIQNTT KLSLLQATLQ LFTTLVVILG 420
  421 NNLQLQIELT LTRIFSILLD DGTANNSSSE NKNKPSIIKE LLIEQISILW TRSPSFFTST 480
  481 FINFDCNLDR ADVSINFLKA LTKLALPESA LTTTESVPPI CLEGLVSLVD DMFDHMKDID 540
  541 REEFG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [546-626] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RQKNEMEILK KRDRKTEFIE CTNAFNEKPK KGIPMLIEKG FIASDSDKDI AEFLFNNNNR  60
   61 MNKKTIGLLL CHPDKVSLLN E

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1294.154902
Match: 1ku1A_
Description: ARF guanine-exchange factor 2, Gea2
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [627-792] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YIRLFDFSGL RVDEAIRILL TKFRLPGESQ QIERIIEAFS SAYCENQDYD PSKISDNAED  60
   61 DISTVQPDAD SVFILSYSII MLNTDLHNPQ VKEHMSFEDY SGNLKGCCNH KDFPFWYLDR 120
  121 IYCSIRDKEI VMPEEHHGNE KWFEDAWNNL ISSTTVITEI KKDTQS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1294.154902
Match: 1ku1A_
Description: ARF guanine-exchange factor 2, Gea2
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [793-1114] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VMDKLTPLEL LNFDRAIFKQ VGPSIVSTLF NIYVVASDDH ISTRMITSLD KCSYISAFFD  60
   61 FKDLFNDILN SIAKGTTLIN SSHDDELSTL AFEYGPMPLV QIKFEDTNTE IPVSTDAVRF 120
  121 GRSFKGQLNT VVFFRIIRRN KDPKIFSKEL WLNIVNIILT LYEDLILSPD IFPDLQKRLK 180
  181 LSNLPKPSPE ISINKSKESK GLLSTFASYL KGDEEPTEEE IKSSKKAMEC IKSSNIAASV 240
  241 FGNESNITAD LIKTLLDSAK TEKNADNSRY FEAELLFIIE LTIALFLFCK EEKELGKFIL 300
  301 QKVFQLSHTK GLTKRTVRRM LT

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 9.55
Match: 1qgkA
Description: Importin beta
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [1115-1320] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YKILLISLCA DQTEYLSKLI NDELLKKGDI FTQKFFATNQ GKEFLKRLFS LTESEFYRGF  60
   61 LLGNENFWKF LRKVTAMKEQ SESIFEYLNE SIKTDSNILT NENFMWVLGL LDEISSMGAV 120
  121 GNHWEIEYKK LTESGHKIDK ENPYKKSIEL SLKSIQLTSH LLEDNNDLRK NEIFAIIQAL 180
  181 AHQCINPCKQ ISEFAVVTLE QTLINK

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 9.55
Match: 1qgkA
Description: Importin beta
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ARF guanyl-nucleotide exchange factor activity 6.57705646633597 bayes_pls_golite062009
GTPase regulator activity 3.37865780899325 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 3.23621073985922 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 3.11224105598265 bayes_pls_golite062009
small GTPase regulator activity 2.75174745190211 bayes_pls_golite062009
enzyme regulator activity 1.95578809138334 bayes_pls_golite062009
binding 1.3334812784277 bayes_pls_golite062009
protein binding 0.917306986228715 bayes_pls_golite062009
cytoskeletal protein binding 0.909190013421997 bayes_pls_golite062009
phosphoinositide binding 0.0750646331148792 bayes_pls_golite062009
phospholipid binding 0.0172309833091902 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [1321-1404] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IEIPTNEMES VEELIEGGLL PLLNSSETQE DQKILISSIL TIISNVYLHY LKLGKTSNET  60
   61 FLKILSIFNK FVEDSDIEKK LQQL

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 9.55
Match: 1qgkA
Description: Importin beta
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [1405-1459] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ILDKKSIEKG NGSSSHGSAH EQTPESNDVE IEATAPIDDN TDDDNKPKLS DVEKD

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.21
Match: 1ao6A
Description: Serum albumin
Matching Structure (courtesy of the PDB):

Predicted Domain #8
Region A:
Residues: [1177-1252] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNENFWKFLR KVTAMKEQSE SIFEYLNESI KTDSNILTNE NFMWVLGLLD EISSMGAVGN  60
   61 HWEIEYKKLT ESGHKI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #9
Region A:
Residues: [1253-1459] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DKENPYKKSI ELSLKSIQLT SHLLEDNNDL RKNEIFAIIQ ALAHQCINPC KQISEFAVVT  60
   61 LEQTLINKIE IPTNEMESVE ELIEGGLLPL LNSSETQEDQ KILISSILTI ISNVYLHYLK 120
  121 LGKTSNETFL KILSIFNKFV EDSDIEKKLQ QLILDKKSIE KGNGSSSHGS AHEQTPESND 180
  181 VEIEATAPID DNTDDDNKPK LSDVEKD

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle