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Protein Overview: GEA1_YEAST

General Information:
Name(s) found: GEA1_YEAST [Swiss-Prot]
Description(s) found:
  • ARF guanine-nucleotide exchange factor 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GEA1 PE=1 SV=1 [Swiss-Prot]
    • Organism: Saccharomyces cerevisiae S288c
    Length: 1408 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHDVPMETVL AVNPATMIVK ECINLCSAMN KQSRDKSQTS VAALLGGGSD IFLSQSDSFV  60
   61 DSFHNLPTSS YHDPLISGLV QLRLKINDLK GLDSLNALEL LKPFLEIVSA SSVSGYTTSL 120
  121 ALDSLQKVFT LKIINKTFND IQIAVRETVV ALTHCRFEAS KQISDDSVLL KVVTLLRDII 180
  181 TSSFGDYLSD TIIYDVLQTT LSLACNTQRS EVLRKTAEVT IAGITVKLFT KLKLLDPPTK 240
  241 TEKYINDESY TDNNLKDDII GTTTSDNDLS STDDDSAVAD DNKNEKPVQQ VIREQENDEE 300
  301 TAEKAENVEP NYGITVIKDY LGLLLSLVMP ENRMKHTTSA MKLSLQLINA AIEISGDKFP 360
  361 LYPRLFSLIS DPIFKSVLFI IQSSTQYSLL QATLQLFTSL VVILGDYLPM QIELTLRRIF 420
  421 EILEDTTISG DVSKQKPPAI RELIIEQLSI LWIHSPAFFL QLFVNFDCNL DRSDLSIDFI 480
  481 KELTKFSLPA AAVNTSNNIP PICLEGVLSL IENIYNDLQR FDRAEFVKNQ KEIDILKQRD 540
  541 RKTEFILCVE TFNEKAKKGI QMLIEKGFID SDSNRDIASF LFLNNGRLNK KTIGLLLCDP 600
  601 KKTSLLKEFI DLFDFKGLRV DEAIRILLTK FRLPGESQQI ERIVEAFSSK YSADQSNDKV 660
  661 ELEDKKAGKN GSESMTEDDI IHVQPDADSV FVLSYSIIML NTDSHNPQVK DHMTFDDYSN 720
  721 NLRGCYNGKD FPRWYLHKIY TSIKVKEIVM PEEHHGNERW FEDAWNNLIS STSVMTEMQR 780
  781 DFTNPISKLA QIDILQYEKA IFSNVRDIIL KTLFKIFTVA SSDQISLRIL DAISKCTFIN 840
  841 YYFSFDQSYN DTVLHLGEMT TLAQSSAKAV ELDVDSIPLV EIFVEDTGSK ISVSNQSIRL 900
  901 GQNFKAQLCT VLYFQIIKEI SDPSIVSTRL WNQIVQLILK LFENLLMEPN LPFFTNFHSL 960
  961 LKLPELPLPD PDISIRKAKM SRSLLSTFAS YLKGDEEPSE EDIDFSIKAF ECVKASHPLS1020
 1021 SVFENNQLVS PKMIETLLSS LVIEKTSENS PYFEQELLFL LEISIILISE ASYGQEFGAL1080
 1081 IADHMINISN LDGLSKEAIA RLASYKMFLV SRFDNPRDIL SDLIEHDFLV KNEIFNTKYY1140
 1141 ESEWGKQVIN DLFTHLNDVK YNERALKNVK FWNFLRILIS AKDRQFAVYT FLEKYIQNGD1200
 1201 IFVDDGNFMN ILSLLDEMSC AGAVGTKWEQ NYENSVEDGC EAPESNPYRS IIDLSSRSIN1260
 1261 ITADLLSTVG RSNSALNKNE IIAAIQGLAH QCLNPCDELG MQALQALENI LLSRASQLRT1320
 1321 EKVAVDNLLE TGLLPIFELD EIQDVKMKRI TSILSVLSKI FLGQLVEGVT SNETFLRVLN1380
 1381 VFNKYVDDPT VERQLQELII SKREIEKE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..521] MSA 2.04093 View MSA. No confident structure predictions are available.
    2 View Details [522..608] PSI-BLAST 918.154902 ARF guanine-exchange factor 2, Gea2
    3 View Details [609..758] PSI-BLAST 918.154902 ARF guanine-exchange factor 2, Gea2
    4 View Details [759..819] PSI-BLAST 3.39794 Grp1
    5 View Details [820..1048] ORFEUS 8.25 Constant regulatory domain of protein phosphatase 2a, pr65alpha
    6 View Details [1049..1116] ORFEUS 8.25 Constant regulatory domain of protein phosphatase 2a, pr65alpha
    7 View Details [1117..1408] ORFEUS 8.25 Constant regulatory domain of protein phosphatase 2a, pr65alpha

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • ARF guanyl-nucleotide exchange factor activity
    		•  6.57705646633597 bayes_pls_golite062009
  • GTPase regulator activity
    		•  3.37865780899325 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  3.23621073985922 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  3.11224105598265 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  2.75174745190211 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.95578809138334 bayes_pls_golite062009
  • binding
    		•  1.3334812784277 bayes_pls_golite062009
  • protein binding
    		•  0.917306986228715 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.909190013421997 bayes_pls_golite062009
  • phosphoinositide binding
    		•  0.0750646331148792 bayes_pls_golite062009
  • phospholipid binding
    		•  0.0172309833091902 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.79

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle