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View Structure Prediction Details

Protein: GEA1_YEAST
Organism: Saccharomyces cerevisiae S288c
Length: 1408 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GEA1_YEAST.

Description E-value Query
Range
Subject
Range
GEA1 - Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs), involved in vesicular transp...
GEA1_YEAST - ARF guanine-nucleotide exchange factor 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN...
0.0 [1..1408] [1..1408]
GNOM_ARATH - ARF guanine-nucleotide exchange factor GNOM OS=Arabidopsis thaliana GN=GN PE=1 SV=1
0.0 [15..1407] [32..1388]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [15..1407] [32..1388]
BIG1_BOVIN - Brefeldin A-inhibited guanine nucleotide-exchange protein 1 OS=Bos taurus GN=ARFGEF1 PE=1 SV=1
0.0 [214..1396] [326..1497]
gi|225000702 - gi|225000702|gb|AAI72243.1| ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A...
ARFGEF1 - ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)
0.0 [214..1396] [326..1497]

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Predicted Domain #1
Region A:
Residues: [1-521]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHDVPMETVL AVNPATMIVK ECINLCSAMN KQSRDKSQTS VAALLGGGSD IFLSQSDSFV  60
   61 DSFHNLPTSS YHDPLISGLV QLRLKINDLK GLDSLNALEL LKPFLEIVSA SSVSGYTTSL 120
  121 ALDSLQKVFT LKIINKTFND IQIAVRETVV ALTHCRFEAS KQISDDSVLL KVVTLLRDII 180
  181 TSSFGDYLSD TIIYDVLQTT LSLACNTQRS EVLRKTAEVT IAGITVKLFT KLKLLDPPTK 240
  241 TEKYINDESY TDNNLKDDII GTTTSDNDLS STDDDSAVAD DNKNEKPVQQ VIREQENDEE 300
  301 TAEKAENVEP NYGITVIKDY LGLLLSLVMP ENRMKHTTSA MKLSLQLINA AIEISGDKFP 360
  361 LYPRLFSLIS DPIFKSVLFI IQSSTQYSLL QATLQLFTSL VVILGDYLPM QIELTLRRIF 420
  421 EILEDTTISG DVSKQKPPAI RELIIEQLSI LWIHSPAFFL QLFVNFDCNL DRSDLSIDFI 480
  481 KELTKFSLPA AAVNTSNNIP PICLEGVLSL IENIYNDLQR F

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [522-608]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DRAEFVKNQK EIDILKQRDR KTEFILCVET FNEKAKKGIQ MLIEKGFIDS DSNRDIASFL  60
   61 FLNNGRLNKK TIGLLLCDPK KTSLLKE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 918.154902
Match: 1ku1A_
Description: ARF guanine-exchange factor 2, Gea2
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [609-758]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FIDLFDFKGL RVDEAIRILL TKFRLPGESQ QIERIVEAFS SKYSADQSND KVELEDKKAG  60
   61 KNGSESMTED DIIHVQPDAD SVFVLSYSII MLNTDSHNPQ VKDHMTFDDY SNNLRGCYNG 120
  121 KDFPRWYLHK IYTSIKVKEI VMPEEHHGNE 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 918.154902
Match: 1ku1A_
Description: ARF guanine-exchange factor 2, Gea2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ARF guanyl-nucleotide exchange factor activity 6.57705646633597 bayes_pls_golite062009
GTPase regulator activity 3.37865780899325 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 3.23621073985922 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 3.11224105598265 bayes_pls_golite062009
small GTPase regulator activity 2.75174745190211 bayes_pls_golite062009
enzyme regulator activity 1.95578809138334 bayes_pls_golite062009
binding 1.3334812784277 bayes_pls_golite062009
protein binding 0.917306986228715 bayes_pls_golite062009
cytoskeletal protein binding 0.909190013421997 bayes_pls_golite062009
phosphoinositide binding 0.0750646331148792 bayes_pls_golite062009
phospholipid binding 0.0172309833091902 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [759-819]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RWFEDAWNNL ISSTSVMTEM QRDFTNPISK LAQIDILQYE KAIFSNVRDI ILKTLFKIFT  60
   61 V

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.39794
Match: 1fhwA_
Description: Grp1
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [820-1048]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASSDQISLRI LDAISKCTFI NYYFSFDQSY NDTVLHLGEM TTLAQSSAKA VELDVDSIPL  60
   61 VEIFVEDTGS KISVSNQSIR LGQNFKAQLC TVLYFQIIKE ISDPSIVSTR LWNQIVQLIL 120
  121 KLFENLLMEP NLPFFTNFHS LLKLPELPLP DPDISIRKAK MSRSLLSTFA SYLKGDEEPS 180
  181 EEDIDFSIKA FECVKASHPL SSVFENNQLV SPKMIETLLS SLVIEKTSE

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 8.25
Match: 1b3uA
Description: Constant regulatory domain of protein phosphatase 2a, pr65alpha
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [1049-1116]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSPYFEQELL FLLEISIILI SEASYGQEFG ALIADHMINI SNLDGLSKEA IARLASYKMF  60
   61 LVSRFDNP

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 8.25
Match: 1b3uA
Description: Constant regulatory domain of protein phosphatase 2a, pr65alpha
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [1117-1408]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RDILSDLIEH DFLVKNEIFN TKYYESEWGK QVINDLFTHL NDVKYNERAL KNVKFWNFLR  60
   61 ILISAKDRQF AVYTFLEKYI QNGDIFVDDG NFMNILSLLD EMSCAGAVGT KWEQNYENSV 120
  121 EDGCEAPESN PYRSIIDLSS RSINITADLL STVGRSNSAL NKNEIIAAIQ GLAHQCLNPC 180
  181 DELGMQALQA LENILLSRAS QLRTEKVAVD NLLETGLLPI FELDEIQDVK MKRITSILSV 240
  241 LSKIFLGQLV EGVTSNETFL RVLNVFNKYV DDPTVERQLQ ELIISKREIE KE

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 8.25
Match: 1b3uA
Description: Constant regulatory domain of protein phosphatase 2a, pr65alpha
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle