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Protein Overview: IRR1

General Information:
Name(s) found: IRR1 / YIL026C [SGD]
Description(s) found:
Found 23 descriptions.
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  • Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1150 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    nuclear cohesin complex [IDALink to PubMed article][IPILink to PubMed article]
    Biological Process: spore germination [IMPLink to PubMed article]
    mitotic sister chromatid cohesion [IMPLink to PubMed article]
    cytogamy [IMPLink to PubMed article]
    Molecular Function: protein binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTAVRRSTRI RTKSQVIEED YDDEQNTSAQ HVESDKITAK TQHEEEEEQD TGESEESSSE  60
   61 DDYEDQDDDD YVDTATAKRK SRKRKPKSAS NTSSKRQKKK PTSAQKSAVS HAPAYHRSKK 120
  121 DQDQYLEIAK DFQPTELFDI LSTSEDVSIE ELLREWLETY SENRDKFLQE FINLLLNCCG 180
  181 SVARVEDHDV HSNESSNETI GEIQLLFQRQ KLHEFYLLIS KENKKRKNFK MGPLYQNFAE 240
  241 FMTKLLEVAN DLQLLYVESD EDDTQIVTGN LVLDLLTWLS SFSVCKIRCF RYISTLTLYL 300
  301 FQDYLTQQAV NLEKNYLAKL SKQLSLEEKK KRPNNKTLEK LESTIAETQG SKVVIDSIID 360
  361 NIVKLCFVHR YKDVSDLIRS ESMLHLSIWI KNYPEYFLKV TFLKYFGWLL SDNSVSVRLQ 420
  421 VTKILPHLII QNHNSKSTDN SAIRQVFERF KTKILEVAIR DVNLDVRIHS IQVLTEASSL 480
  481 GYLDDSEILI ISSLMFDEEF DPFKTSSFNK RSKFLSTVAK FLARVIKEKF DEFIKTHEDL 540
  541 PKEVDGLEVG PVVQVGIFIK ILNDSLIYHL KDCAEVDSRT KIRMLTQAAE FLSPYISTHL 600
  601 KTICNLLISD TESNELIQKL QNSANNNSDD EDVDDEELDI TPLFPIDRNS TILYLNVFHG 660
  661 LCAGANNPKI QTKDSVKEIV LPLFYDLLNA ASIESADILC PLLESFITFS LDDWISIGYE 720
  721 TELKKITDKT IKAFMDSTIG NSKVDMKYDI FAKFIHHIHH FEKKELQEKF LNQIATLKIH 780
  781 LKKFLQEKMD PNNSRDDYKD LTCSLYELYI NKLTILGRDY PIEVDEELLQ LFLNNFVSRI 840
  841 PIMFQDFDDS TAQEINFKML VLLATWNLEK WREIIEKVRD YENSISKDLR SVWKPIAAII 900
  901 GRLNTLVISL AATNETFENI NSLFYLKWSA CTSLMDIIVA IKIFELKLPA DATTWRYSMS 960
  961 EQFPFYLHDN ASKVLLKIFL YLESLFAKQV DVQLERVADE DANLNDLPET GFFENIETEF1020
 1021 LLFTVKLKGL MKLNILDERF ASRVALNKEK LGPLFKKIVD DTIMENPEPN KKNIQKAKSN1080
 1081 QTQREKAPLQ PNSERETDHA NTENNDPDIP MTIDLEPIEE SSQNNSELAP IEEHPTVVDA1140
 1141 IDNSDEITQD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) IRR1 MCD1 SMC1 SMC3
    View Details (MIPS) Mewes HW, et al. (2004) IRR1 MCD1 REC8 SCC2 SMC1 SMC3
    View Details Krogan NJ, et al. (2006) IRR1 MCD1 SMC1 SMC3
    View Details Gavin AC, et al. (2002) CCT8 GCN1 HHF1, HHF2 IRR1 KAP123 MCD1 NOP12 RVB2 SCC4 SMC1 SMC3 YHB1
    View Details Ho Y, et al. (2002) CDC5 IRR1 IVY1 KAP95 MCD1 NOP13 SMC1 SMC3 SPC72 SRP1
    View Details Qiu et al. (2008) IRR1 REC8 SCC2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TAM41 No Comments Hazbun TR, et al. (2003)
    View Run PAN1 No Comments Toshima J, et al (2006)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data IRR1 and NOP56 Huh WK, et al. (2003)
    View Data IRR1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..162] MSA 5.021974 View MSA. No confident structure predictions are available.
    2 View Details [163..1150] Pfam 1000.0 No description for PF03365 was found. No confident structure predictions are available.
    3 View Details [920..1150] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  2.81296846555705 bayes_pls_golite062009
  • protein binding
    		•  1.63424405980235 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.66737572008694 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.118461769548431 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle